Euroasian Journal of Hepato-Gastroenterology

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2017 | January-June | Volume 7 | Issue 1

EDITORIAL

Mamun Al-Mahtab

Editorial

[Year:2017] [Month:January-June] [Volume:7] [Number:1] [Pages:1] [Pages No:0 - 0]

PDF  |  DOI: 10.5005/ejohg-7-1-i  |  Open Access |  How to cite  | 

ORIGINAL ARTICLE

Dina Zerem, Omar Zerema, Enver Zerem

Role of Clinical, Biochemical, and Imaging Parameters in predicting the Severity of Acute Pancreatitis

[Year:2017] [Month:January-June] [Volume:7] [Number:1] [Pages:5] [Pages No:1 - 5]

PDF  |  DOI: 10.5005/jp-journals-10018-1202  |  Open Access |  How to cite  | 

Abstract

Aim

The assessment of the severity of acute pancreatitis (AP) is important for proper management of the disease and for its prognosis. The aim was to correlate clinical, biochemical, and imaging diagnostic parameters and evaluate their prognostic values in the early assessment of severity of AP.

Materials and methods

We prospectively studied 128 consecutive patients with AP. The predictors were clinical, biochemical, and imaging diagnostic parameters. The outcome measure was the occurrence of complications. Abdominal sonogram, contrast-enhanced computer tomography, and pancreatitis-specific clinical and laboratory findings were done.

Results

According to the Atlanta classification, 84 patients (65.6%) had mild and 44 (34.4%) had severe AP. The severity markers were significantly different between the mild and the severe groups (p < 0.001). Leukocyte count, serum albumin level, C-reactive protein (CRP), Ranson, acute physiology and chronic health evaluation II (APACHE II), and Glasgow score were the factors associated with radiological severity grade. Leukocyte count, CRP, Ranson score, APACHE II, and Glasgow score were the factors associated with the number and appearance of acute fluid collections (AFCs). A significant association was found between the number of AFCs and the occurrence of complications [odds ratio 4.4; 95% confidence interval 2.5–7.6]. Hospital stay was significantly longer in the group with severe disease as compared with the group with mild disease (p < 0.001).

Conclusion

Clinical, biochemical, and imaging diagnostic parameters are related to the clinical course of AP and they can predict its severity. This allows us to determine the severity of the disease and to target the patients with high scores for close monitoring and more aggressive intervention.

How to cite this article

Zerem D, Zerem O, Zerem E. Role of Clinical, Biochemical, and Imaging Parameters in predicting the Severity of Acute Pancreatitis. Euroasian J Hepato-Gastroenterol 2017;7(1):1-5.

ORIGINAL ARTICLE

Mehmet A Erdogan, Ali R Benli, Serap B Acmali, Mustafa Koroglu, Yahya Atayan, Ahmet Danalioglu, Burcak Kayhan

Predictive Value of Mean Platelet Volume in Variceal Bleeding due to Cirrhotic Portal Hypertension

[Year:2017] [Month:January-June] [Volume:7] [Number:1] [Pages:5] [Pages No:6 - 10]

PDF  |  DOI: 10.5005/jp-journals-10018-1203  |  Open Access |  How to cite  | 

Abstract

Aim

To investigate whether mean platelet volume (MPV) is a predictor of variceal bleeding in patients with cirrhotic portal hypertension.

Materials and methods

This prospective cohort was performed in the internal medicine department of our tertiary care center. Cirrhotic patients were allocated into two groups: Group I consisted of 31 cases without a history of variceal bleeding, whereas group II was made up of 31 patients with a history of variceal bleeding. Data derived from medical history, physical examination, ultrasonography, gastrointestinal system endoscopy, complete blood count, hepatic, and renal function tests were recorded and compared between two groups. On physical examination, encephalopathy and ascites were evaluated and graded with respect to Child–Pugh–Turcotte classification.

Results

There was no significant difference between the two groups in terms of age, duration of the disease, and gender of the patient. The only remarkable difference was that hemoglobin (p = 0.02) and hematocrit (p = 0.02) values were lower in group II. Neither the etiology of bleeding was different between groups nor did MPV seem to have a noteworthy impact on bleeding. Interestingly, risk of variceal bleeding increased in parallel to the higher grade of varices.

Conclusion

Our results imply that there is a correlation between the grade of varices and esophageal variceal bleeding in cirrhotic patients. However, association between MPV and variceal bleeding could not be demonstrated. Utilization of noninvasive tests as predictors in these patients necessitates further controlled trials on larger series.

How to cite this article

Erdogan MA, Benli AR, Acmali SB, Koroglu M, Atayan Y, Danalioglu A, Kayhan B. Predictive Value of Mean Platelet Volume in Variceal Bleeding due to Cirrhotic Portal Hypertension. Euroasian J Hepato-Gastroenterol 2017;7(1):6-10.

ORIGINAL ARTICLE

Mustafa Guclu, A Faruq Agan

Association of Severity of Helicobacter pylori Infection with Peripheral Blood Neutrophil to Lymphocyte Ratio and Mean Platelet Volume

[Year:2017] [Month:January-June] [Volume:7] [Number:1] [Pages:6] [Pages No:11 - 16]

PDF  |  DOI: 10.5005/jp-journals-10018-1204  |  Open Access |  How to cite  | 

Abstract

Aim

To determine the correlation of Helicobacter pylori infection with peripheral blood neutrophil/lymphocyte ratio (NLR) and mean platelet volume (MPV).

Materials and methods

The NLR, MPV, platelets, leukocytes, neutrophils, and lymphocytes were calculated and the differences between groups were investigated.

Results

A total of 199 patients were included in the study. Neutrophil/lymphocyte ratio was statistically lower in H. pylori-positive patients than in H. pylori-negative patients (1.94 ± 0.79 vs 2.67 ± 2.35 respectively, p = 0.04). There was no significant difference between H. pylori-negative patients and H. pylori-positive patients of severe intensity in terms of MPV. However, peripheral blood lymphocytes and platelets were statistically significantly higher in H. pylori-positive patients of severe intensity (lymphocytes 2150 ± 826 vs 2954 ± 2436 respectively, p = 0.000 and platelets 258247 ± 69494 vs 265611 ± 113397 respectively, p = 0.02) compared with H. pylori-negative patients.

Conclusion

A moderate increase in the intensity of H. pylori does not lead to a significant change in MPV as measured by hemogram; however, it gives rise to a statistically significant fall in NLR. Presence of severe H. pylori-positive intensity leads to a statistically significant increase in peripheral blood lymphocytes and platelets compared with H. pylori-negative patients.

How to cite this article

Guclu M, Agan AF. Association of Severity of Helicobacter pylori Infection with Peripheral Blood Neutrophil to Lymphocyte Ratio and Mean Platelet Volume. Euroasian J Hepato-Gastroenterol 2017;7(1):11-16.

ORIGINAL ARTICLE

Banu N Şirvan, Merve K Usta, Nuray U Kızılkan, Nafiye Urgancı

Are Synbiotics added to the Standard Therapy to eradicate Helicobacter pylori in Children Beneficial? A Randomized Controlled Study

[Year:2017] [Month:January-June] [Volume:7] [Number:1] [Pages:6] [Pages No:17 - 22]

PDF  |  DOI: 10.5005/jp-journals-10018-1205  |  Open Access |  How to cite  | 

Abstract

Aim

We aimed to evaluate the role of the addition of Bifidobacterium lactis-containing synbiotic to the triple therapy in the case of Helicobacter pylori eradication, the dyspeptic symptoms, and reducing the side effects of antibiotics.

Materials and methods

A total of 104 children aged between 5 and 17 years, who were histopathologically diagnosed with H. pylori were enrolled in this study, of whom 100 were included in the analysis. Patients were randomly classified into two groups. In the first group, 50 patients were administered amoxicillin + clarithromycin + lansoprazole for 14 days and B. lactis-containing synbiotic. In the second group, 50 patients were treated with the standard triple therapy. All patients were given information after completion of therapy.

Results

H. pylori eradication was achieved in 88% in group I who received standard therapy with additional synbiotic and 72% in group II (p = 0.046). The number of patients in the second group who suffered from abdominal pain between the 3rd and 14th day of the treatment was higher (p < 0.05). The addition of probiotics to the triple therapy significantly reduced the frequency of diarrhea, but no significant difference was detected in the frequency of metallic taste (p = 0.04, p = 0.418 respectively).

Conclusion

The addition of synbiotic to the triple therapy is effective for eradicating H. pylori infection in children and is usually helpful to reduce or eliminate dyspeptic symptoms like abdominal pain, diarrhea, and vomiting. This study suggest that improved tolerance to the eradication treatment also reduces the treatment failure by adding probiotics and encourages the future study using probiotic supplementation in H. pylori treatment.

How to cite this article

Şirvan BN, Usta MK, Kızılkan NU, Urgancı N. Are Synbiotics added to the Standard Therapy to eradicate Helicobacter Pylori in Children Beneficial? A Randomized Controlled Study. Euroasian J Hepato-Gastroenterol 2017;7(1):17-22.

ORIGINAL ARTICLE

Mukta Waghmare, Hemanshi Shah, Charu Tiwari, Kiran Khedkar, Suraj Gandhi

Management of Liver Abscess in Children: Our Experience

[Year:2017] [Month:January-June] [Volume:7] [Number:1] [Pages:4] [Pages No:23 - 26]

PDF  |  DOI: 10.5005/jp-journals-10018-1206  |  Open Access |  How to cite  | 

Abstract

Introduction

Liver abscess is common in pediatric population in India. Children have unique set of predisposing factors and clinical features. Liver abscesses are infectious, space-occupying lesions in the liver; the two most common abscesses being pyogenic and amebic. Its severity depends on the source of the infection and the underlying condition of the patient.

Materials and methods

A total of 34 patients less than 12 years were assessed in a retrospective study from January 2012 to 2016. Patients were assessed in terms of age of presentation, etiology, bacteriology, diagnosis, and modality of treatment.

Results

The mean age of presentation was 6.3 years. Average volume of abscess was 164 cc. Nine patients (26.4%) underwent percutaneous needle aspiration under ultrasound guidance with wide bore needle (18 G disposable needle). Three patients required more than two sittings of aspiration. Patients with volume more than 80 cc were treated with catheter drainage. Twenty patients (58.8%) underwent ultrasound-guided percutaneous catheter drainage. Two patients required catheter drainage for large abscess and needle aspiration for the smaller abscess.

Conclusion

Antimicrobial therapy along with percutaneous drainage constitutes the mainstay of treatment, whereas open surgical drainage should be reserved for selected cases.

How to cite this article

Waghmare M, Shah H, Tiwari C, Khedkar K, Gandhi S. Management of Liver Abscess in Children: Our Experience. Euroasian J Hepato-Gastroenterol 2017;7(1):23-26.

ORIGINAL ARTICLE

Rafael V Picon, Lúcia Fendt, Karine Amaral, Paulo D Picon

Prediction of Sustained Virological Response to Peginterferon-based Therapy for Chronic Hepatitis C: Regression Analysis of a Cohort from Rio Grande do Sul, Brazil

[Year:2017] [Month:January-June] [Volume:7] [Number:1] [Pages:7] [Pages No:27 - 33]

PDF  |  DOI: 10.5005/jp-journals-10018-1207  |  Open Access |  How to cite  | 

Abstract

Aim

Peginterferon plus ribavirin (peg-IFN/RBV) is still the standard of care for treatment of hepatitis C virus (HCV) in many countries. Given the high toxicity of this regimen, our study aimed to develop a prediction tool that can identify which patients are unlikely to benefit from peg-IFN/RBV and could thus postpone treatment in favor of new-generation direct-acting antivirals.

Materials and methods

Binary regression was performed using demographic, clinical, and laboratory covariates and sustained virological response (SVR) outcomes from a prospective cohort of individuals referred for therapy from 2003 to 2008 in a public HCV treatment center in Rio Grande do Sul, Brazil.

Results

Of the 743 participants analyzed, 489 completed 48 weeks of treatment (65.8%). A total of 202 of those who completed peg-IFN/RBV therapy achieved SVR (27.2% responders), 196 did not (26.4%), and 91 had missing viral load (VL) at week 72 (12.2% loss to follow-up). The remainder discontinued therapy (n = 254 [34.2%]), 78 (30.7%) doing so due to adverse effects. Baseline covariates included in the regression model were sex, age, human immunodeficiency virus, infection status, aspartate transaminase, alanine transaminase, hemoglobin, platelets, serum creatinine, prothrombin time, pretreatment VL, cirrhosis on liver biopsy, and treatment naivety. A predicted SVR of 17.9% had 90.0% sensitivity for detecting true nonresponders. The negative likelihood ratio at a predicted SVR of 17.9% was 0.16, and the negative predictive value was 92.6%.

Conclusion

Easily obtainable variables can identify patients that will likely not benefit from peg-IFN-based therapy. This prediction model might be useful to clinicians.

Clinical significance

To our knowledge, this is the only prediction tool that can reliably help clinicians to postpone peg-IFN/RBV therapy for HCV genotype 1 patients.

How to cite this article

Picon RV, Fendt L, Amaral K, Picon PD. Prediction of Sustained Virological Response to Peginterferon-based Therapy for Chronic Hepatitis C: Regression Analysis of a Cohort from Rio Grande do Sul, Brazil. Euroasian J Hepato-Gastroenterol 2017;7(1):27-33.

REVIEW ARTICLE

Gokben Ozbey, Alfizah Hanafiah

Epidemiology, Diagnosis, and Risk Factors of Helicobacter pylori Infection in Children

[Year:2017] [Month:January-June] [Volume:7] [Number:1] [Pages:6] [Pages No:34 - 39]

PDF  |  DOI: 10.5005/jp-journals-10018-1208  |  Open Access |  How to cite  | 

Abstract

How to cite this article

Ozbey G, Hanafiah A. Epidemiology, Diagnosis, and Risk Factors of Helicobacter pylori Infection in Children. Euroasian J Hepato-Gastroenterol 2017;7(1):34-39.

MINI REVIEW

Elimination of Hepatitis Viruses: Bangladesh Scenario

[Year:2017] [Month:January-June] [Volume:7] [Number:1] [Pages:3] [Pages No:40 - 42]

PDF  |  DOI: 10.5005/jp-journals-10018-1209  |  Open Access |  How to cite  | 

Abstract

How to cite this article

Mahtab MA. Elimination of Hepatitis Viruses: Bangladesh Scenario. Euroasian J Hepato-Gastroenterol 2017;7(1):40-42.

MINI REVIEW

Chham Samnang, Bun Sreng, Ork Vichit, Yuong Vuthikol, Chum Aun

Immunization against Viral Hepatitis B: Lessons Learnt from Kingdom of Cambodia

[Year:2017] [Month:January-June] [Volume:7] [Number:1] [Pages:5] [Pages No:43 - 47]

PDF  |  DOI: 10.5005/jp-journals-10018-1210  |  Open Access |  How to cite  | 

Abstract

How to cite this article

Sreng B, Vichit O, Vuthikol Y, Aun C, Samnang C. Immunization against Viral Hepatitis B: Lessons Learnt from Kingdom of Cambodia. Euroasian J Hepato-Gastroenterol 2017;7(1):43-47.

MINI REVIEW

Tarana Gupta, Sahaj Rathi, Radha K Dhiman

Managing Encephalopathy in the Outpatient Setting

[Year:2017] [Month:January-June] [Volume:7] [Number:1] [Pages:7] [Pages No:48 - 54]

PDF  |  DOI: 10.5005/jp-journals-10018-1211  |  Open Access |  How to cite  | 

Abstract

How to cite this article:

Gupta T, Rathi S, Dhiman RK. Managing Encephalopathy in the Outpatient Setting. Euroasian J Hepato-Gastroenterol 2017;7(1):48-54.

MINI REVIEW

Epidemiology of Hepatitis B and C in Republic of Indonesia

[Year:2017] [Month:January-June] [Volume:7] [Number:1] [Pages:5] [Pages No:55 - 59]

PDF  |  DOI: 10.5005/jp-journals-10018-1212  |  Open Access |  How to cite  | 

Abstract

How to cite this article:

Muljono DH. Epidemiology of Hepatitis B and C in Republic of Indonesia. Euroasian J Hepato-Gastroenterol 2017;7(1):55-59.

MINI REVIEW

Tatsuya Kanto, Sachiyo Yoshio

Hepatitis Action Plan and Changing Trend of Liver Disease in Japan: Viral Hepatitis and Nonalcoholic Fatty Liver Disease

[Year:2017] [Month:January-June] [Volume:7] [Number:1] [Pages:5] [Pages No:60 - 64]

PDF  |  DOI: 10.5005/jp-journals-10018-1213  |  Open Access |  How to cite  | 

Abstract

How to cite this article:

Kanto T, Yoshio S. Hepatitis Action Plan and Changing Trend of Liver Disease in Japan: Viral Hepatitis and Nonalcoholic Fatty Liver Disease. Euroasian J Hepato-Gastroenterol 2017;7(1):60-64.

MINI REVIEW

Muhammad Radzi Abu Hassan, Rosaida Md Said

Chronic Viral Hepatitis in Malaysia: “Where are we now?”

[Year:2017] [Month:January-June] [Volume:7] [Number:1] [Pages:3] [Pages No:65 - 67]

PDF  |  DOI: 10.5005/jp-journals-10018-1214  |  Open Access |  How to cite  | 

Abstract

How to cite this article:

Raihan R, Mohamed R, Hasan MRA, Rosaida MS. Chronic Viral Hepatitis in Malaysia: “Where are we now?” Euroasian J Hepato-Gastroenterol 2017;7(1):65-67.

MINI REVIEW

Oidov Baatarkhuu, G Uugantsetseg, D Munkh-Orshikh, N Naranzul, S Badamjav, D Tserendagva, J Amarsanaa, Kim Do Young

Viral Hepatitis and Liver Diseases in Mongolia

[Year:2017] [Month:January-June] [Volume:7] [Number:1] [Pages:5] [Pages No:68 - 72]

PDF  |  DOI: 10.5005/jp-journals-10018-1215  |  Open Access |  How to cite  | 

Abstract

How to cite this article:

Baatarkhuu O, Uugantsetseg G, Munkh-Orshikh D, Naranzul N, Badamjav S, Tserendagva D, Amarsanaa J, Young KD. Viral Hepatitis and Liver Diseases in Mongolia. Euroasian J Hepato-Gastroenterol 2017;7(1):68-72.

MINI REVIEW

Birendra P Gupta, Thupten K Lama

Current Treatment of Acute and Chronic Hepatitis E Virus Infection: Role of Antivirals

[Year:2017] [Month:January-June] [Volume:7] [Number:1] [Pages:5] [Pages No:73 - 77]

PDF  |  DOI: 10.5005/jp-journals-10018-1216  |  Open Access |  How to cite  | 

Abstract

How to cite this article:

Shrestha A, Gupta BP, Lama TK. Current Treatment of Acute and Chronic Hepatitis E Virus Infection: Role of Antivirals. Euroasian J Hepato-Gastroenterol 2017;7(1):73-77.

MINI REVIEW

Hasitha S Wijewantha

Liver Disease in Sri Lanka

[Year:2017] [Month:January-June] [Volume:7] [Number:1] [Pages:4] [Pages No:78 - 81]

PDF  |  DOI: 10.5005/jp-journals-10018-1217  |  Open Access |  How to cite  | 

Abstract

Address reprint requests to:

Wijewantha HS. Liver Disease in Sri Lanka. Euroasian J Hepato-Gastroenterol 2017;7(1):78-81.

MINI REVIEW

HBV Treatment in Turkey: The Value of Hepatitis B Surface Antigen Quantification of Chronic Hepatitis B Patients in the Long-term Follow-up—A Single-center Study

[Year:2017] [Month:January-June] [Volume:7] [Number:1] [Pages:2] [Pages No:82 - 83]

PDF  |  DOI: 10.5005/jp-journals-10018-1218  |  Open Access |  How to cite  | 

Abstract

How to cite this article:

Ozkan H. HBV Treatment in Turkey: The Value of Hepatitis B Surface Antigen Quantification of Chronic Hepatitis B Patients in the Long-term Follow-up—A Single-center Study. Euroasian J Hepato-Gastroenterol 2017;7(1):82-83.

CASE REPORT

Gautham Krishnamurthy, Harjeet Singh, Rajinder Singh

Successful Conservative Management of Spontaneous Antegrade Migration of Feeding Jejunostomy

[Year:2017] [Month:January-June] [Volume:7] [Number:1] [Pages:3] [Pages No:84 - 86]

PDF  |  DOI: 10.5005/jp-journals-10018-1219  |  Open Access |  How to cite  | 

Abstract

How to cite this article:

Krishnamurthy G, Pandit N, Singh H, Singh R. Successful Conservative Management of Spontaneous Antegrade Migration of Feeding Jejunostomy. Euroasian J Hepato-Gastroenterol 2017;7(1):84-86.

CASE REPORT

Ambikavathy Mohan, Kumar Srinivasan

Scrotal Cystocele in a Sliding Left Inguinoscrotal Hernia: A Case Report and Review of Literature

[Year:2017] [Month:January-June] [Volume:7] [Number:1] [Pages:2] [Pages No:87 - 88]

PDF  |  DOI: 10.5005/jp-journals-10018-1220  |  Open Access |  How to cite  | 

Abstract

How to cite this article:

Mohan A, Srinivasan K. Scrotal Cystocele in a Sliding Left Inguinoscrotal Hernia: A Case Report and Review of Literature. Euroasian J Hepato-Gastroenterol 2017;7(1):87-88.

CASE REPORT

Hakan Atas, Hakan Bulus, Gökhan Akkurt

Sclerosing Angiomatoid Nodular Transformation of the Spleen: An uncommon Cause of Abdominal Pain

[Year:2017] [Month:January-June] [Volume:7] [Number:1] [Pages:3] [Pages No:89 - 91]

PDF  |  DOI: 10.5005/jp-journals-10018-1221  |  Open Access |  How to cite  | 

Abstract

How to cite this article

Atas H, Bulus H, Akkurt G. Sclerosing Angiomatoid Nodular Transformation of the Spleen: An uncommon Cause of Abdominal Pain. Euroasian J Hepato-Gastroenterol 2017;7(1):89-91.

CASE REPORT

Fatih Karakaya, Zihni Karaeren, Sibel Perçinel

Persistent Elevation of CA 19-9 Levels in the Long-term Follow-up before Laryngeal Cancer

[Year:2017] [Month:January-June] [Volume:7] [Number:1] [Pages:3] [Pages No:92 - 94]

PDF  |  DOI: 10.5005/jp-journals-10018-1222  |  Open Access |  How to cite  | 

Abstract

Introduction

CA 19-9 is used as a tumor marker in colon, pancreas, biliary, and gastric cancers. Laryngeal cancer is the most common malignant epithelial tumor among head and neck cancers and has no specific tumor marker.

Case report

A 66-year-old male patient had severe reflux symptoms during 5 years and had an isolated CA 19-9 elevation. Follow-up analysis revealed that he had larynx cancer and after laryngectomy, CA 19-9 levels decreased to normal range.

Discussion

Currently, CA 19-9 is not a marker for malignancy. Laryngeal carcinoma has no specific tumor marker, but laryngeal squamous cell carcinoma may be manifested by elevated CA 19-9 levels.

How to cite this article

Özkan H, Karakaya F, Karaeren Z, Perçinel S. Persistent Elevation of CA 19-9 Levels in the Long-term Follow-up before Laryngeal Cancer. Euroasian J Hepato-Gastroenterol 2017;7(1):92-94.

LETTER TO EDITOR

Birnur Yilmaz, Safak Kiziltas, Semsi Yildiz, Burçak Gümüs, Halime Çevik

Simultaneous Immunoglobulin G4-associated Autoimmune Hepatitis and Autoimmune Pancreatitis

[Year:2017] [Month:January-June] [Volume:7] [Number:1] [Pages:2] [Pages No:95 - 96]

PDF  |  DOI: 10.5005/jp-journals-10018-1223  |  Open Access |  How to cite  | 

Abstract

Yilmaz B, Kiziltas S, Yildiz S, Gümüs B, Çevik H. Simultaneous Immunoglobulin G4-associated Autoimmune Hepatitis and Autoimmune Pancreatitis. Euroasian J Hepato-Gastroenterol 2017;7(1):95-96.

LETTER TO EDITOR

Seema Dayal

Synchronous Colon Carcinoma and Tuberculosis: Coincidence or Linked

[Year:2017] [Month:January-June] [Volume:7] [Number:1] [Pages:2] [Pages No:97 - 98]

PDF  |  DOI: 10.5005/jp-journals-10018-1224  |  Open Access |  How to cite  | 

Abstract

Dayal S. Synchronous Colon Carcinoma and Tuberculosis: Coincidence or Linked. Euroasian J Hepato-Gastroenterol 2017;7(1):97-98.

LETTER TO EDITOR

Elif Karadeli, Sermin Tok, Gurcan Erbay

Long Segment Intestinal Invagination in an Adult Case

[Year:2017] [Month:January-June] [Volume:7] [Number:1] [Pages:2] [Pages No:99 - 100]

PDF  |  DOI: 10.5005/jp-journals-10018-1225  |  Open Access |  How to cite  | 

Abstract

Karadeli E, Parlakgumus A, Tok S, Erbay G. Long Segment Intestinal Invagination in an Adult Case. Euroasian J Hepato-Gastroenterol 2017;7(1):99-100.

BRIEF REPORT

Sameh M Abdel Monem

Probiotic Therapy in Patients with Nonalcoholic Steatohepatitis in Zagazig University Hospitals

[Year:2017] [Month:January-June] [Volume:7] [Number:1] [Pages:6] [Pages No:101 - 106]

PDF  |  DOI: 10.5005/jp-journals-10018-1226  |  Open Access |  How to cite  | 

Abstract

Aim

Nonalcoholic fatty liver disease (NAFLD) is probably the most common liver disorder in the world. A subgroup of NAFLD patients is characterized by injury to the hepatocytes and inflammation in addition to excessive fat (steatohepatitis), the latter condition is nominated nonalcoholic steatohepatitis (NASH). This work aimed to evaluate the role of probiotics on the outcome of NASH in patients admitted to the Tropical Medicine Department, Faculty of Medicine, Zagazig University (inpatients and outpatients).

Materials and methods

This study was performed on 30 patients (17 males and 13 females), with body mass index from 30 to 35 and average age of 44 years with bright fatty liver in ultrasonography and raised alanine transaminase (ALT) and aspartate transaminase (AST) and positive liver biopsy findings. The patients were divided into group I (case group) that included 15 patients who received probiotics and group II of 15 patients as control group who did not receive probiotics; the study was conducted between November 2014 and April 2016. Clinical assessment, laboratory evaluation, pelvic-abdominal ultrasound, and liver biopsy of all cases were carried out.

Results

In this study, there was significant decrease in liver enzymes (ALT and AST) and no statistically significant other laboratory findings. Also there was relief for dyspepsia in some patients.

Conclusion

Probiotics treatment is effective, safe, well-tolerated, inexpensive, appropriate for long-term use, and optimally, works at multiple levels to downregulate inflammatory mediators, and therefore, probiotics could be an option in the treatment of NASH.

How to cite this article

Monem SMA. Probiotic Therapy in Patients with Nonalcoholic Steatohepatitis in Zagazig University Hospitals. Euroasian J Hepato-Gastroenterol 2017;7(1):101-106.

BRIEF REPORT

Shamima Akhter, Kutub U Mollick, Mohammad H Uddin

Prevalence of Hepatitis B Virus and Hepatitis C Virus in a Tea Garden of Bangladesh

[Year:2017] [Month:January-June] [Volume:7] [Number:1] [Pages:4] [Pages No:107 - 110]

PDF  |  DOI: 10.5005/jp-journals-10018-1227  |  Open Access |  How to cite  | 

Abstract

Introduction

The overall health status of workers of tea garden of Bangladesh is below the national standard. Also, almost nothing has been reported about status of hepatitis virus infection among these population and there is also a lack of consensus.

Materials and methods

Several health-related facts, especially those of liver diseases, were collected from 130 workers of tea garden via questionnaire. Sera were also collected from these subjects to assess positivity of hepatitis B surface antigen (HBsAg) and antibody to hepatitis C virus (anti-HCV). Hepatitis B virus (HBV) genotype was also done using genotype-specific primers in HBsAg-positive sera.

Results

Out of 130 tea garden workers, 5 were positive for HBsAg; however, none was reactive to anti-HCV. Genotyping of HBV deoxyribonucleic acid of 4 sera samples revealed that 2 belonged to genotype A, 1 to genotype C, and 1 to genotype D. Various risk factors were documented in HBV-infected subjects by analyzing the questionnaire.

Conclusion

Hepatitis B virus in considerable high percentage is prevalent among workers of tea garden in Bangladesh, and immediate vaccination against HBV should be employed. Also, health education system should be accentuated in specific population like tea garden workers.

How to cite this article

Al Mahtab M, Akhter S, Mollick KU, Uddin MH, Khan SI, Akbar SMF. Prevalence of Hepatitis B Virus and Hepatitis C Virus in a Tea Garden of Bangladesh. Euroasian J Hepato-Gastroenterol 2017;7(1):107-110.

BRIEF REPORT

Salimur Rahman, Mobin Khan, Muhammad M Hussain, Shahidul Islam, Nooruddin Ahmed

Relationship between Hepatitis B Viral Deoxyribonucleic Acid Load and Hepatocellular Carcinoma

[Year:2017] [Month:January-June] [Volume:7] [Number:1] [Pages:2] [Pages No:111 - 112]

PDF  |  DOI: 10.5005/jp-journals-10018-1228  |  Open Access |  How to cite  | 

Abstract

Introduction

Hepatitis B virus (HBV) infection is an established cause of hepatocellular carcinoma (HCC) and is associated with poor prognosis. High HBV deoxyribonucleic acid (DNA) load has been identified in HCC and hepatitis B surface antigen-positive patients.

Materials and methods

This study was done in the Department of Hepatology, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh, from January 2006 to December 2007. Thirty patients with HBV infection-related HCC were enrolled. Another 30 patients with HBV-related liver diseases without HCC were analyzed as controls.

Results

The HCC patients had a high viral load (>105 copies/mL), while all of the controls had low (<105 copies/mL) viral load.

Conclusion

It seems that patients with HCC bear high HBV DNA loads in Bangladesh, but the causes underlying this remain to be resolved.

How to cite this article

Hussain MM, Al Mahtab M, Islam S, Ahmed N, Rahman S, Khan M. Relationship between Hepatitis B Viral Deoxyribonucleic Acid Load and Hepatocellular Carcinoma. Euroasian J Hepato-Gastroenterol 2017;7(1):111-112.

BRIEF REPORT

Mohammad H Uddin, Sheikh MN Alam, Ahmed L Moben, Mohammad A Alam

Therapy Targeting Stem Cell in Patients with Decompensated Cirrhosis of Liver in a Tertiary Treatment Care Center of Bangladesh

[Year:2017] [Month:January-June] [Volume:7] [Number:1] [Pages:3] [Pages No:113 - 115]

PDF  |  DOI: 10.5005/jp-journals-10018-1229  |  Open Access |  How to cite  | 

Abstract

Introduction

Decompensated cirrhosis is associated with significantly high mortality resulting from hepatic failure, and liver transplantation seems to be the only viable indication for its management. The objective of this study is to assess if granulocyte colony-stimulating factor (G-CSF), a stimulatory of stem cell in vivo, may be of any benefit for patients with decompensated cirrhosis of liver.

Materials and methods

Seventeen consecutive patients with decompensated cirrhosis of liver were recruited in this prospective study. They received injection of G-CSF (30 IU) over a period of 6 weeks (12 injections) in addition to standard of care.

Results

Patients were followed up at the end of treatment and at 12 weeks of treatment. Treatment was well tolerated, and no significant adverse event was recorded in any patient. Fifteen out of 17 (88%) patients were alive at last follow-up. Although serum bilirubin, albumin, and prothrombin time improved in some patients, statistically significant improvement of Child–Pugh score could not be documented.

Conclusion

The study establishes the safety of G-CSF therapy in patients with decompensated cirrhosis of liver. Besides, such therapy may also have survival benefit, although long-term follow-up is needed to assess its real utility in clinical perspectives.

How to cite this article

Al Mahtab M, Alam SMN, Moben AL, Raihan R, Alam MA, Rahim MA, Uddin MH, Akbar SMF. Therapy Targeting Stem Cell in Patients with Decompensated Cirrhosis of Liver in a Tertiary Treatment Care Center of Bangladesh. Euroasian J Hepato-Gastroenterol 2017;7(1):113-115.

Source of support

The study was partially supported by a grant from Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh

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