[Year:2017] [Month:January-June] [Volume:7] [Number:1] [Pages:1] [Pages No:0 - 0]
DOI: 10.5005/ejohg-7-1-i | Open Access | How to cite |
[Year:2017] [Month:January-June] [Volume:7] [Number:1] [Pages:5] [Pages No:1 - 5]
DOI: 10.5005/jp-journals-10018-1202 | Open Access | How to cite |
Abstract
The assessment of the severity of acute pancreatitis (AP) is important for proper management of the disease and for its prognosis. The aim was to correlate clinical, biochemical, and imaging diagnostic parameters and evaluate their prognostic values in the early assessment of severity of AP. We prospectively studied 128 consecutive patients with AP. The predictors were clinical, biochemical, and imaging diagnostic parameters. The outcome measure was the occurrence of complications. Abdominal sonogram, contrast-enhanced computer tomography, and pancreatitis-specific clinical and laboratory findings were done. According to the Atlanta classification, 84 patients (65.6%) had mild and 44 (34.4%) had severe AP. The severity markers were significantly different between the mild and the severe groups (p < 0.001). Leukocyte count, serum albumin level, C-reactive protein (CRP), Ranson, acute physiology and chronic health evaluation II (APACHE II), and Glasgow score were the factors associated with radiological severity grade. Leukocyte count, CRP, Ranson score, APACHE II, and Glasgow score were the factors associated with the number and appearance of acute fluid collections (AFCs). A significant association was found between the number of AFCs and the occurrence of complications [odds ratio 4.4; 95% confidence interval 2.5–7.6]. Hospital stay was significantly longer in the group with severe disease as compared with the group with mild disease (p < 0.001). Clinical, biochemical, and imaging diagnostic parameters are related to the clinical course of AP and they can predict its severity. This allows us to determine the severity of the disease and to target the patients with high scores for close monitoring and more aggressive intervention. Zerem D, Zerem O, Zerem E. Role of Clinical, Biochemical, and Imaging Parameters in predicting the Severity of Acute Pancreatitis. Euroasian J Hepato-Gastroenterol 2017;7(1):1-5.
Predictive Value of Mean Platelet Volume in Variceal Bleeding due to Cirrhotic Portal Hypertension
[Year:2017] [Month:January-June] [Volume:7] [Number:1] [Pages:5] [Pages No:6 - 10]
DOI: 10.5005/jp-journals-10018-1203 | Open Access | How to cite |
Abstract
To investigate whether mean platelet volume (MPV) is a predictor of variceal bleeding in patients with cirrhotic portal hypertension. This prospective cohort was performed in the internal medicine department of our tertiary care center. Cirrhotic patients were allocated into two groups: Group I consisted of 31 cases without a history of variceal bleeding, whereas group II was made up of 31 patients with a history of variceal bleeding. Data derived from medical history, physical examination, ultrasonography, gastrointestinal system endoscopy, complete blood count, hepatic, and renal function tests were recorded and compared between two groups. On physical examination, encephalopathy and ascites were evaluated and graded with respect to Child–Pugh–Turcotte classification. There was no significant difference between the two groups in terms of age, duration of the disease, and gender of the patient. The only remarkable difference was that hemoglobin (p = 0.02) and hematocrit (p = 0.02) values were lower in group II. Neither the etiology of bleeding was different between groups nor did MPV seem to have a noteworthy impact on bleeding. Interestingly, risk of variceal bleeding increased in parallel to the higher grade of varices. Our results imply that there is a correlation between the grade of varices and esophageal variceal bleeding in cirrhotic patients. However, association between MPV and variceal bleeding could not be demonstrated. Utilization of noninvasive tests as predictors in these patients necessitates further controlled trials on larger series. Erdogan MA, Benli AR, Acmali SB, Koroglu M, Atayan Y, Danalioglu A, Kayhan B. Predictive Value of Mean Platelet Volume in Variceal Bleeding due to Cirrhotic Portal Hypertension. Euroasian J Hepato-Gastroenterol 2017;7(1):6-10.
[Year:2017] [Month:January-June] [Volume:7] [Number:1] [Pages:6] [Pages No:11 - 16]
DOI: 10.5005/jp-journals-10018-1204 | Open Access | How to cite |
Abstract
To determine the correlation of The NLR, MPV, platelets, leukocytes, neutrophils, and lymphocytes were calculated and the differences between groups were investigated. A total of 199 patients were included in the study. Neutrophil/lymphocyte ratio was statistically lower in A moderate increase in the intensity of Guclu M, Agan AF. Association of Severity of
[Year:2017] [Month:January-June] [Volume:7] [Number:1] [Pages:6] [Pages No:17 - 22]
DOI: 10.5005/jp-journals-10018-1205 | Open Access | How to cite |
Abstract
We aimed to evaluate the role of the addition of A total of 104 children aged between 5 and 17 years, who were histopathologically diagnosed with The addition of synbiotic to the triple therapy is effective for eradicating Şirvan BN, Usta MK, Kızılkan NU, Urgancı N. Are Synbiotics added to the Standard Therapy to eradicate
Management of Liver Abscess in Children: Our Experience
[Year:2017] [Month:January-June] [Volume:7] [Number:1] [Pages:4] [Pages No:23 - 26]
DOI: 10.5005/jp-journals-10018-1206 | Open Access | How to cite |
Abstract
Liver abscess is common in pediatric population in India. Children have unique set of predisposing factors and clinical features. Liver abscesses are infectious, space-occupying lesions in the liver; the two most common abscesses being pyogenic and amebic. Its severity depends on the source of the infection and the underlying condition of the patient. A total of 34 patients less than 12 years were assessed in a retrospective study from January 2012 to 2016. Patients were assessed in terms of age of presentation, etiology, bacteriology, diagnosis, and modality of treatment. The mean age of presentation was 6.3 years. Average volume of abscess was 164 cc. Nine patients (26.4%) underwent percutaneous needle aspiration under ultrasound guidance with wide bore needle (18 G disposable needle). Three patients required more than two sittings of aspiration. Patients with volume more than 80 cc were treated with catheter drainage. Twenty patients (58.8%) underwent ultrasound-guided percutaneous catheter drainage. Two patients required catheter drainage for large abscess and needle aspiration for the smaller abscess. Antimicrobial therapy along with percutaneous drainage constitutes the mainstay of treatment, whereas open surgical drainage should be reserved for selected cases. Waghmare M, Shah H, Tiwari C, Khedkar K, Gandhi S. Management of Liver Abscess in Children: Our Experience. Euroasian J Hepato-Gastroenterol 2017;7(1):23-26.
[Year:2017] [Month:January-June] [Volume:7] [Number:1] [Pages:7] [Pages No:27 - 33]
DOI: 10.5005/jp-journals-10018-1207 | Open Access | How to cite |
Abstract
Peginterferon plus ribavirin (peg-IFN/RBV) is still the standard of care for treatment of hepatitis C virus (HCV) in many countries. Given the high toxicity of this regimen, our study aimed to develop a prediction tool that can identify which patients are unlikely to benefit from peg-IFN/RBV and could thus postpone treatment in favor of new-generation direct-acting antivirals. Binary regression was performed using demographic, clinical, and laboratory covariates and sustained virological response (SVR) outcomes from a prospective cohort of individuals referred for therapy from 2003 to 2008 in a public HCV treatment center in Rio Grande do Sul, Brazil. Of the 743 participants analyzed, 489 completed 48 weeks of treatment (65.8%). A total of 202 of those who completed peg-IFN/RBV therapy achieved SVR (27.2% responders), 196 did not (26.4%), and 91 had missing viral load (VL) at week 72 (12.2% loss to follow-up). The remainder discontinued therapy (n = 254 [34.2%]), 78 (30.7%) doing so due to adverse effects. Baseline covariates included in the regression model were sex, age, human immunodeficiency virus, infection status, aspartate transaminase, alanine transaminase, hemoglobin, platelets, serum creatinine, prothrombin time, pretreatment VL, cirrhosis on liver biopsy, and treatment naivety. A predicted SVR of 17.9% had 90.0% sensitivity for detecting true nonresponders. The negative likelihood ratio at a predicted SVR of 17.9% was 0.16, and the negative predictive value was 92.6%. Easily obtainable variables can identify patients that will likely not benefit from peg-IFN-based therapy. This prediction model might be useful to clinicians. To our knowledge, this is the only prediction tool that can reliably help clinicians to postpone peg-IFN/RBV therapy for HCV genotype 1 patients. Picon RV, Fendt L, Amaral K, Picon PD. Prediction of Sustained Virological Response to Peginterferon-based Therapy for Chronic Hepatitis C: Regression Analysis of a Cohort from Rio Grande do Sul, Brazil. Euroasian J Hepato-Gastroenterol 2017;7(1):27-33.
Epidemiology, Diagnosis, and Risk Factors of Helicobacter pylori Infection in Children
[Year:2017] [Month:January-June] [Volume:7] [Number:1] [Pages:6] [Pages No:34 - 39]
DOI: 10.5005/jp-journals-10018-1208 | Open Access | How to cite |
Abstract
Ozbey G, Hanafiah A. Epidemiology, Diagnosis, and Risk Factors of
Elimination of Hepatitis Viruses: Bangladesh Scenario
[Year:2017] [Month:January-June] [Volume:7] [Number:1] [Pages:3] [Pages No:40 - 42]
DOI: 10.5005/jp-journals-10018-1209 | Open Access | How to cite |
Abstract
Mahtab MA. Elimination of Hepatitis Viruses: Bangladesh Scenario. Euroasian J Hepato-Gastroenterol 2017;7(1):40-42.
Immunization against Viral Hepatitis B: Lessons Learnt from Kingdom of Cambodia
[Year:2017] [Month:January-June] [Volume:7] [Number:1] [Pages:5] [Pages No:43 - 47]
DOI: 10.5005/jp-journals-10018-1210 | Open Access | How to cite |
Abstract
Sreng B, Vichit O, Vuthikol Y, Aun C, Samnang C. Immunization against Viral Hepatitis B: Lessons Learnt from Kingdom of Cambodia. Euroasian J Hepato-Gastroenterol 2017;7(1):43-47.
Managing Encephalopathy in the Outpatient Setting
[Year:2017] [Month:January-June] [Volume:7] [Number:1] [Pages:7] [Pages No:48 - 54]
DOI: 10.5005/jp-journals-10018-1211 | Open Access | How to cite |
Abstract
Gupta T, Rathi S, Dhiman RK. Managing Encephalopathy in the Outpatient Setting. Euroasian J Hepato-Gastroenterol 2017;7(1):48-54.
Epidemiology of Hepatitis B and C in Republic of Indonesia
[Year:2017] [Month:January-June] [Volume:7] [Number:1] [Pages:5] [Pages No:55 - 59]
DOI: 10.5005/jp-journals-10018-1212 | Open Access | How to cite |
Abstract
Muljono DH. Epidemiology of Hepatitis B and C in Republic of Indonesia. Euroasian J Hepato-Gastroenterol 2017;7(1):55-59.
[Year:2017] [Month:January-June] [Volume:7] [Number:1] [Pages:5] [Pages No:60 - 64]
DOI: 10.5005/jp-journals-10018-1213 | Open Access | How to cite |
Abstract
Kanto T, Yoshio S. Hepatitis Action Plan and Changing Trend of Liver Disease in Japan: Viral Hepatitis and Nonalcoholic Fatty Liver Disease. Euroasian J Hepato-Gastroenterol 2017;7(1):60-64.
Chronic Viral Hepatitis in Malaysia: “Where are we now?”
[Year:2017] [Month:January-June] [Volume:7] [Number:1] [Pages:3] [Pages No:65 - 67]
DOI: 10.5005/jp-journals-10018-1214 | Open Access | How to cite |
Abstract
Raihan R, Mohamed R, Hasan MRA, Rosaida MS. Chronic Viral Hepatitis in Malaysia: “Where are we now?” Euroasian J Hepato-Gastroenterol 2017;7(1):65-67.
Viral Hepatitis and Liver Diseases in Mongolia
[Year:2017] [Month:January-June] [Volume:7] [Number:1] [Pages:5] [Pages No:68 - 72]
DOI: 10.5005/jp-journals-10018-1215 | Open Access | How to cite |
Abstract
Baatarkhuu O, Uugantsetseg G, Munkh-Orshikh D, Naranzul N, Badamjav S, Tserendagva D, Amarsanaa J, Young KD. Viral Hepatitis and Liver Diseases in Mongolia. Euroasian J Hepato-Gastroenterol 2017;7(1):68-72.
Current Treatment of Acute and Chronic Hepatitis E Virus Infection: Role of Antivirals
[Year:2017] [Month:January-June] [Volume:7] [Number:1] [Pages:5] [Pages No:73 - 77]
DOI: 10.5005/jp-journals-10018-1216 | Open Access | How to cite |
Abstract
Shrestha A, Gupta BP, Lama TK. Current Treatment of Acute and Chronic Hepatitis E Virus Infection: Role of Antivirals. Euroasian J Hepato-Gastroenterol 2017;7(1):73-77.
[Year:2017] [Month:January-June] [Volume:7] [Number:1] [Pages:4] [Pages No:78 - 81]
DOI: 10.5005/jp-journals-10018-1217 | Open Access | How to cite |
Abstract
Wijewantha HS. Liver Disease in Sri Lanka. Euroasian J Hepato-Gastroenterol 2017;7(1):78-81.
[Year:2017] [Month:January-June] [Volume:7] [Number:1] [Pages:2] [Pages No:82 - 83]
DOI: 10.5005/jp-journals-10018-1218 | Open Access | How to cite |
Abstract
Ozkan H. HBV Treatment in Turkey: The Value of Hepatitis B Surface Antigen Quantification of Chronic Hepatitis B Patients in the Long-term Follow-up—A Single-center Study. Euroasian J Hepato-Gastroenterol 2017;7(1):82-83.
Successful Conservative Management of Spontaneous Antegrade Migration of Feeding Jejunostomy
[Year:2017] [Month:January-June] [Volume:7] [Number:1] [Pages:3] [Pages No:84 - 86]
DOI: 10.5005/jp-journals-10018-1219 | Open Access | How to cite |
Abstract
Krishnamurthy G, Pandit N, Singh H, Singh R. Successful Conservative Management of Spontaneous Antegrade Migration of Feeding Jejunostomy. Euroasian J Hepato-Gastroenterol 2017;7(1):84-86.
Scrotal Cystocele in a Sliding Left Inguinoscrotal Hernia: A Case Report and Review of Literature
[Year:2017] [Month:January-June] [Volume:7] [Number:1] [Pages:2] [Pages No:87 - 88]
DOI: 10.5005/jp-journals-10018-1220 | Open Access | How to cite |
Abstract
Mohan A, Srinivasan K. Scrotal Cystocele in a Sliding Left Inguinoscrotal Hernia: A Case Report and Review of Literature. Euroasian J Hepato-Gastroenterol 2017;7(1):87-88.
Sclerosing Angiomatoid Nodular Transformation of the Spleen: An uncommon Cause of Abdominal Pain
[Year:2017] [Month:January-June] [Volume:7] [Number:1] [Pages:3] [Pages No:89 - 91]
DOI: 10.5005/jp-journals-10018-1221 | Open Access | How to cite |
Abstract
Atas H, Bulus H, Akkurt G. Sclerosing Angiomatoid Nodular Transformation of the Spleen: An uncommon Cause of Abdominal Pain. Euroasian J Hepato-Gastroenterol 2017;7(1):89-91.
Persistent Elevation of CA 19-9 Levels in the Long-term Follow-up before Laryngeal Cancer
[Year:2017] [Month:January-June] [Volume:7] [Number:1] [Pages:3] [Pages No:92 - 94]
DOI: 10.5005/jp-journals-10018-1222 | Open Access | How to cite |
Abstract
CA 19-9 is used as a tumor marker in colon, pancreas, biliary, and gastric cancers. Laryngeal cancer is the most common malignant epithelial tumor among head and neck cancers and has no specific tumor marker. A 66-year-old male patient had severe reflux symptoms during 5 years and had an isolated CA 19-9 elevation. Follow-up analysis revealed that he had larynx cancer and after laryngectomy, CA 19-9 levels decreased to normal range. Currently, CA 19-9 is not a marker for malignancy. Laryngeal carcinoma has no specific tumor marker, but laryngeal squamous cell carcinoma may be manifested by elevated CA 19-9 levels. Özkan H, Karakaya F, Karaeren Z, Perçinel S. Persistent Elevation of CA 19-9 Levels in the Long-term Follow-up before Laryngeal Cancer. Euroasian J Hepato-Gastroenterol 2017;7(1):92-94.
Simultaneous Immunoglobulin G4-associated Autoimmune Hepatitis and Autoimmune Pancreatitis
[Year:2017] [Month:January-June] [Volume:7] [Number:1] [Pages:2] [Pages No:95 - 96]
DOI: 10.5005/jp-journals-10018-1223 | Open Access | How to cite |
Abstract
Yilmaz B, Kiziltas S, Yildiz S, Gümüs B, Çevik H. Simultaneous Immunoglobulin G4-associated Autoimmune Hepatitis and Autoimmune Pancreatitis. Euroasian J Hepato-Gastroenterol 2017;7(1):95-96.
Synchronous Colon Carcinoma and Tuberculosis: Coincidence or Linked
[Year:2017] [Month:January-June] [Volume:7] [Number:1] [Pages:2] [Pages No:97 - 98]
DOI: 10.5005/jp-journals-10018-1224 | Open Access | How to cite |
Abstract
Dayal S. Synchronous Colon Carcinoma and Tuberculosis: Coincidence or Linked. Euroasian J Hepato-Gastroenterol 2017;7(1):97-98.
Long Segment Intestinal Invagination in an Adult Case
[Year:2017] [Month:January-June] [Volume:7] [Number:1] [Pages:2] [Pages No:99 - 100]
DOI: 10.5005/jp-journals-10018-1225 | Open Access | How to cite |
Abstract
Karadeli E, Parlakgumus A, Tok S, Erbay G. Long Segment Intestinal Invagination in an Adult Case. Euroasian J Hepato-Gastroenterol 2017;7(1):99-100.
Probiotic Therapy in Patients with Nonalcoholic Steatohepatitis in Zagazig University Hospitals
[Year:2017] [Month:January-June] [Volume:7] [Number:1] [Pages:6] [Pages No:101 - 106]
DOI: 10.5005/jp-journals-10018-1226 | Open Access | How to cite |
Abstract
Nonalcoholic fatty liver disease (NAFLD) is probably the most common liver disorder in the world. A subgroup of NAFLD patients is characterized by injury to the hepatocytes and inflammation in addition to excessive fat (steatohepatitis), the latter condition is nominated nonalcoholic steatohepatitis (NASH). This work aimed to evaluate the role of probiotics on the outcome of NASH in patients admitted to the Tropical Medicine Department, Faculty of Medicine, Zagazig University (inpatients and outpatients). This study was performed on 30 patients (17 males and 13 females), with body mass index from 30 to 35 and average age of 44 years with bright fatty liver in ultrasonography and raised alanine transaminase (ALT) and aspartate transaminase (AST) and positive liver biopsy findings. The patients were divided into group I (case group) that included 15 patients who received probiotics and group II of 15 patients as control group who did not receive probiotics; the study was conducted between November 2014 and April 2016. Clinical assessment, laboratory evaluation, pelvic-abdominal ultrasound, and liver biopsy of all cases were carried out. In this study, there was significant decrease in liver enzymes (ALT and AST) and no statistically significant other laboratory findings. Also there was relief for dyspepsia in some patients. Probiotics treatment is effective, safe, well-tolerated, inexpensive, appropriate for long-term use, and optimally, works at multiple levels to downregulate inflammatory mediators, and therefore, probiotics could be an option in the treatment of NASH. Monem SMA. Probiotic Therapy in Patients with Nonalcoholic Steatohepatitis in Zagazig University Hospitals. Euroasian J Hepato-Gastroenterol 2017;7(1):101-106.
Prevalence of Hepatitis B Virus and Hepatitis C Virus in a Tea Garden of Bangladesh
[Year:2017] [Month:January-June] [Volume:7] [Number:1] [Pages:4] [Pages No:107 - 110]
DOI: 10.5005/jp-journals-10018-1227 | Open Access | How to cite |
Abstract
The overall health status of workers of tea garden of Bangladesh is below the national standard. Also, almost nothing has been reported about status of hepatitis virus infection among these population and there is also a lack of consensus. Several health-related facts, especially those of liver diseases, were collected from 130 workers of tea garden via questionnaire. Sera were also collected from these subjects to assess positivity of hepatitis B surface antigen (HBsAg) and antibody to hepatitis C virus (anti-HCV). Hepatitis B virus (HBV) genotype was also done using genotype-specific primers in HBsAg-positive sera. Out of 130 tea garden workers, 5 were positive for HBsAg; however, none was reactive to anti-HCV. Genotyping of HBV deoxyribonucleic acid of 4 sera samples revealed that 2 belonged to genotype A, 1 to genotype C, and 1 to genotype D. Various risk factors were documented in HBV-infected subjects by analyzing the questionnaire. Hepatitis B virus in considerable high percentage is prevalent among workers of tea garden in Bangladesh, and immediate vaccination against HBV should be employed. Also, health education system should be accentuated in specific population like tea garden workers. Al Mahtab M, Akhter S, Mollick KU, Uddin MH, Khan SI, Akbar SMF. Prevalence of Hepatitis B Virus and Hepatitis C Virus in a Tea Garden of Bangladesh. Euroasian J Hepato-Gastroenterol 2017;7(1):107-110.
Relationship between Hepatitis B Viral Deoxyribonucleic Acid Load and Hepatocellular Carcinoma
[Year:2017] [Month:January-June] [Volume:7] [Number:1] [Pages:2] [Pages No:111 - 112]
DOI: 10.5005/jp-journals-10018-1228 | Open Access | How to cite |
Abstract
Hepatitis B virus (HBV) infection is an established cause of hepatocellular carcinoma (HCC) and is associated with poor prognosis. High HBV deoxyribonucleic acid (DNA) load has been identified in HCC and hepatitis B surface antigen-positive patients. This study was done in the Department of Hepatology, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh, from January 2006 to December 2007. Thirty patients with HBV infection-related HCC were enrolled. Another 30 patients with HBV-related liver diseases without HCC were analyzed as controls. The HCC patients had a high viral load (>105 copies/mL), while all of the controls had low (<105 copies/mL) viral load. It seems that patients with HCC bear high HBV DNA loads in Bangladesh, but the causes underlying this remain to be resolved. Hussain MM, Al Mahtab M, Islam S, Ahmed N, Rahman S, Khan M. Relationship between Hepatitis B Viral Deoxyribonucleic Acid Load and Hepatocellular Carcinoma. Euroasian J Hepato-Gastroenterol 2017;7(1):111-112.
[Year:2017] [Month:January-June] [Volume:7] [Number:1] [Pages:3] [Pages No:113 - 115]
DOI: 10.5005/jp-journals-10018-1229 | Open Access | How to cite |
Abstract
Decompensated cirrhosis is associated with significantly high mortality resulting from hepatic failure, and liver transplantation seems to be the only viable indication for its management. The objective of this study is to assess if granulocyte colony-stimulating factor (G-CSF), a stimulatory of stem cell Seventeen consecutive patients with decompensated cirrhosis of liver were recruited in this prospective study. They received injection of G-CSF (30 IU) over a period of 6 weeks (12 injections) in addition to standard of care. Patients were followed up at the end of treatment and at 12 weeks of treatment. Treatment was well tolerated, and no significant adverse event was recorded in any patient. Fifteen out of 17 (88%) patients were alive at last follow-up. Although serum bilirubin, albumin, and prothrombin time improved in some patients, statistically significant improvement of Child–Pugh score could not be documented. The study establishes the safety of G-CSF therapy in patients with decompensated cirrhosis of liver. Besides, such therapy may also have survival benefit, although long-term follow-up is needed to assess its real utility in clinical perspectives. Al Mahtab M, Alam SMN, Moben AL, Raihan R, Alam MA, Rahim MA, Uddin MH, Akbar SMF. Therapy Targeting Stem Cell in Patients with Decompensated Cirrhosis of Liver in a Tertiary Treatment Care Center of Bangladesh. Euroasian J Hepato-Gastroenterol 2017;7(1):113-115. The study was partially supported by a grant from Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh