Cancer Antigen-125 is Specifically Associated with Ascites and has no Relation with Liver Function in Liver Cirrhosis
Mohammed Ali Chowdhury, Xiubin Zhang, Wei Han
Citation Information :
Chowdhury MA, Zhang X, Han W. Cancer Antigen-125 is Specifically Associated with Ascites and has no Relation with Liver Function in Liver Cirrhosis. Euroasian J Hepatogastroenterol 2013; 3 (2):108-110.
Background: Cancer antigen-125 (CA-125) is a high molecular
weight glycoprotein used as a marker for ovarian carcinoma.
But its involvement is also observed in many benign conditions
particularly in liver cirrhosis and ascites. However, the reason
behind it remains unclear.
Materials and methods: A total of 53 patients with liver
cirrhosis, Budd-Chiari syndrome and tuberculous peritonitis
were enrolled in this study. The degree of ascites was graded to
into mild, moderate and severe. CA-125 levels of all the patients
were measured along with other liver parameters.
Results: No association was observed between CA-125 levels
of liver cirrhosis patients and parameters of liver function tests.
All the patients with ascites had elevated level of CA-125,
whereas most of the patients without ascites had CA-125 levels
under the normal range. However, the levels of CA-125 were
without ascites (p < 0.05).
Conclusion: The elevation of CA-125 in liver cirrhosis may
be related to ascites and not dependent on parameters of liver
dysfunction. Therefore, CA-125 may be used as a predictor of
ascites in patients with liver cirrhosis.
Bast RC Jr, Feeney M, Lazarus H, Nadler LM, Colvin RB, Knapp RC. Reactivity of a monoclonal antibody with human ovarian carcinoma. J Clin Invest 1981 Nov;68(5):1331-1337
CA 125: a misleading tumor marker? Int J Gynaecol Obstet 1996 Nov;55(2):179-180
The CA 125 tumour-associated antigen: a review of the literature. Hum Reprod 1989 Jan;4(1):1-12
Use of the CA 125 antigen in diagnosis and monitoring of ovarian carcinoma. Eur J Obstet Gynecol Reprod Biol 1985 Jun;19(6):354-356
N Engl J Med 1983 Oct;309(15):883-887
Immunopathologic characterization of a monoclonal antibody that recognizes common surface-antigens of human ovarian tumors of serous, endometroid, and clear cell types. Am J Clin Pathol 1983 Jan;79(1):98-104
Ovarian cancer antigen ! Cancer 1986 Apr;57(7):1327-1329
Serum CA125 in women with endometriosis and chronic pelvic pain. Fertil Steril 1989 Jan;51(1):68-70
Enzyme immune assay determination of CA125 in serum, peritoneal fluid, and follicular fluid from women with minimal endometriosis after ovarian hyperstimulation. Fertil Steril 1989 Feb;51(2):344-347
Cancer antigen 125 associated with multiple benign and malignant pathologies. Ann Surg Oncol 2003 Mar;10(2):150-154
Serum CA 125 levels in patients with chronic heart failure and accompanying Y ~ XX Z%ZG& * *! 12. Bergmann JF, Bidart JM, George M, Beaugrand M, Levy VG, Bohuon C. Elevation of CA 125 in patients with benign and malignant ascites. Cancer 1987 Jan;59(2):213-217
Cancer antigen 125: a sensitive marker of ascites in patients with liver cirrhosis. Am J Gastroenterol 1999 Jun;94(6):1613-1618
Clinl Chem 1991 Aug;37(8):1379-1383
Cancer antigen 125 in patients with chronic liver disease. Mayo Clin Proc 2002 Jun;77(6):538-541
Elevated levels of cancer antigen CA-125 in patients with chronic liver diseases, with and without ascites. Exp Clin Hepatol 2005;3:30-33
CA 125 serum levels in patients with non-neoplastic liver diseases. A clinical and laboratory study. Scand J Clin Lab Invest 1992 May;52(3):201-206
Korean J Gastroenterol 2003 Nov;42(5):409-414
Special considerations in interpreting liver function test. Am Fam Physician 1999 Apr;59(8):2223-2230
Elevation of serum and ascites cancer antigen 125 levels in patients with liver cirrhosis. J Gastroenterol Hepatol 2003 Nov;18(11):1315-1316
Evaluation on clinical value of serum CA-125 in hepatitis cirrhosis. Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi 2010 Oct;24(5):334-336
Cancer antigen 125 levels in patients with ascites. Turk J Gastroenterol 2003 Dec;14(4):257-261
Role of cancer antigen-125 from pleural $ Med Res 2007 Jan;125(1):25-30
How to interpret serum CA 125 levels in patients with serosal involvement? A clinical dilemma. Oncology 2003;65(1):1-6
CA 125 secretion by peritoneal mesothelial cells. J Clin Pathol 1994 Mar;47(3):263-265
What do we know about the origin of CA 125? Eur J Obstet Gynecol Reprod Biol 1993 Apr;49(1-2):93-98
Binding of ovarian cancer antigen CA125/MUC16 to mesothelin mediates cell adhesion. J Biol Chem 2004 Mar;279(10):9190-9198
Ascites: diagnosis and management. Medi Clin North Am 2009 Jul;93(4):801-817.