Orthotopic liver transplantation is an established treatment for
patients with severe acute and end-stage chronic liver disease.
The shortage of donor organs continues to be the rate-limiting
factor for liver transplantation throughout the world. Hepatocyte
transplantation is a promising treatment for several liver diseases
and can, also, be used as a ‘bridge’ to liver transplantation in
cases of liver failure.
The drawbridge phenomenon: Representational reasoning or perceptual preference? Dev Psychol 1999;35:427-35
Treatment of fulminant liver failure by transplantation of microencapsulated primary or immortalized xenogeneic hepatocytes. Xenotransplantation 2005;12:457-64
Coencapsulation of hepatocytes and bone marrow cells: In vitro and in vivo studies. Biotechnol Annu Rev 2006;12:137-51
Transdifferentiation of bioencapsulated bone marrow cells into hepatocyte-like cells in the 90% hepatectomized rat model. Liver Transpl 2006;12:566-72
Intrasplenic transplantation of encapsulated hepatocytes decreases mortality and improves liver functions in fulminant hepatic failure from 90% partial hepatectomy in rats. Transplant 2005;79:783-90
Preincubation of rat and human hepatocytes with cytoprotectants prior to cryopreservation can improve viability and function upon thawing. Liver Transpl 2006;12:165-77
Hepatocyte transplantation in the treatment of liver diseases future seems bright after all. Pediatr Transplant 2008;12:4-5
Cryopreservation of primary human hepatocytes: The benefit of trehalose as an additional cryoprotective agent. Liver Transpl 2007;13: 38-45
Cryopreservation of isolated human hepatocytes for transplantation: State of the art. Cryobiology 2006;53:149-59
Treatment of liver failure in rats with end-stage cirrhosis by transplantation of immortalized hepatocytes. Hepatol 2002;36:386-94
Construction of a nontumorigenic rat hepatocyte cell line for transplantation: Reversal of hepatocyte immortalization by site-specific excision of the SV40 T antigen. J Hepatol 2000;33:701-08
Development of cell therapy strategies to overcome copper toxicity in the LEC rat model of Wilson disease. Regen Med 2008;3:165-73
Irradiation as preparative regimen for hepatocyte transplantation causes prolonged cell cycle block. Int J Radiat Biol 2008;84:285-98
Selective portal vein embolization and ligation trigger different regenerative responses in the rat liver. Hepatology 2008;47:1615-23
Fulminant hepatic failure in rats: Survival and effect on blood chemistry and liver regeneration. Hepatol 1996;24:1452-59
Portal branch ligation induces efficient retrovirus mediated gene delivery in rat liver. J Gene Med 2004;6:507-13
Humanized mice in translational biomedical research. Nat Rev Immunol 2007;7:118-30
High-yield preparation of isolated rat liver parenchymal cells: A biochemical and fine structural study. J Cell Biol 1969;43:506-20
Laparoscopyassisted creation of a liver failure model in pigs. Cell Transplant 2008;17:187-93
Hepatocyte transplantation in man. Transplant Proc 1992;24:3052-53
Human fetal hepatocyte transplantation in patients with fulminant hepatic failure. Transplantation 1994;58:951-52
Permanent access to the portal system for cellular transplantation using an implantable port device. Liver Transpl 2004;10:1213-15
Human hepatocyte transplantation: Worldwide results. Transplantation 2006;82:441-49
Successful ex vivo gene therapy directed to liver in a patient with familial hypercholesterolaemia. Nat Genet 1994;6:335-41
Transplantation of human hepatocytes. Transplant Proc 1997;29:2103-06
Liver cell transplantation for the treatment of inborn errors of metabolism. J Inher Metab Dis 2008;31:164-72
Sustained engraftment and tissue enzyme activity after liver cell transplantation for argininosuccinate lyase deficiency. Gastroenterol 2006;130: 1317-23
Hepatocyte Transplantation: Clinical experience and potential for future use. Cell Transplant 2006;15:105-10
