Euroasian Journal of Hepato-Gastroenterology

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VOLUME 2 , ISSUE 1 ( January-June, 2012 ) > List of Articles

ORIGINAL ARTICLE

Role of Interferon-gamma and Interleukin-12 in the Immunopathogenesis of Hepatitis B Virus Infection

Nishat Afroz, Meher Rizvi, Mohd Azam, MR Ajmal, Abida Malik, Indu Shukla

Citation Information : Afroz N, Rizvi M, Azam M, Ajmal M, Malik A, Shukla I. Role of Interferon-gamma and Interleukin-12 in the Immunopathogenesis of Hepatitis B Virus Infection. Euroasian J Hepatogastroenterol 2012; 2 (1):5-9.

DOI: 10.5005/jp-journals-10018-1022

License: CC BY-NC 4.0

Published Online: 01-01-2012


Abstract

Objective: To study the role of interleukin (IL)-12 and interferon (IFN)- in immunopathogenesis of hepatitis B virus (HBV) infection. Materials and methods: One hundred and fifty-seven patients with hepatitis B were screened by serological and molecular markers for HBV. Serum IL-12 and IFN- levels were estimated. Results: Among patients with acute HBV (AHB), the mean levels of IFN- (52.35 pg/ml) and IL-12 (57.12 pg/ml) were significantly higher in patients with nonnecrotizing inflammation (NNI) compared to those in patients with necrotizing inflammation (NI) (32.17 pg/ml and 42 pg/ml for IFN- and IL- 12 respectively). In chronic HBV (CHB) with NI, IFN- levels were much higher than the same in AHB. However, no significant difference was found in IL-12 levels. IL-12 levels (25.76 pg/ml) were lower in NNI of CHB patients, while the levels of IL-12 were comparable between NI patients with AHB and CHB. Both IFN- and IL-12 were higher in hepatitis B e-antigen (HBeAg)-negative patients than HBeAg-positive patients. . Conclusion: Both IFN- and IL-12 appear to play a role in AHB and HBeAg negativity, however, further study will be required to get their precise role.


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