Euroasian journal of hepato-gastroenterology

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VOLUME 2 , ISSUE 1 ( January-June, 2012 ) > List of Articles

ORIGINAL ARTICLE

Etiological and Clinical Patterns of Isolated Hepatomegaly at Rajshahi, Bangladesh

Chanchal Kumar Ghosh, Fakhrul Islam, Ershaduddin Ahmed, Dilip Kumar Ghosh, Azizul Haque, QT Islam, MA Zahir

Citation Information : Kumar Ghosh C, Islam F, Ahmed E, Kumar Ghosh D, Haque A, Islam Q, Zahir M. Etiological and Clinical Patterns of Isolated Hepatomegaly at Rajshahi, Bangladesh. Euroasian J Hepatogastroenterol 2012; 2 (1):1-4.

DOI: 10.5005/jp-journals-10018-1021

License: CC BY-NC 4.0

Published Online: 01-01-2011

Copyright Statement:  Copyright © 2012; The Author(s).


Abstract

Background: Hepatomegaly, a common clinical finding, is usually associated with splenomegaly. However, sometimes there may be isolated hepatomegaly without splenomegaly in different pathological conditions. An account of that at Rajshahi, Bangladesh has been given in this study. Materials and methods: This prospective study was carried out in different medicine units of Rajshahi Medical College Hospital, Rajshahi, Bangladesh on consecutive 100 hospitaladmitted patients having isolated hepatomegaly. Results: Most common cause of isolated hepatomegaly was liver abscess (34.0%) followed by congestive cardiac failure (30.0%). Viral hepatitis accounted for about 14% cases of isolated hepatomegaly. Fatty liver and hepatocellular carcinoma were also responsible for isolated hepatomegaly in some patients. Conclusion: Taken together, isolated hepatomegaly varies from comparatively benign condition like fatty liver to fatal condition like hepatocellular carcinoma. Multicenter study with large sample size is warranted to develop more insights about diagnosis and management of isolated hepatomegaly.


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  1. Chapman RW, Collier JD, Hayes PC. Liver and biliary tract disease. In Davidson’s principles and practice of medicine Table 2: Histopathological diagnosis of liver biopsy of patients with isolated hepatomegaly Histopathological diagnosis Frequency Percentage Primary HCC 6 24.0 Secondary cancer of liver 8 32.0 Tubercular hepatitis 1 04.0 Consistent with liver abscess 3 12.0 Fatty liver 2 08.0 Normal histology 5 20.0 Total 25 100.0 Liver biopsy was performed in 25 patients with isolated hepatomegaly Table 1: The extent of isolated hepatomegaly in different pathological conditions Disease Liver span (in cm) Total 12.5-15.5 15.6-18.5 >18.6 Liver abscess 7 (20.6) 15 (44.1) 12 (35.3) 34 (100) Congestive cardiac failure 18 (60.0) 10 (33.3) 2 (6.7) 30 (100) Hepatitis 11 (64.7) 6 (35.3) 0 (0.0) 17 (100) Carcinoma of the liver 0 (0.0) 5 (35.7) 9 (64.3) 14 (100) Others 1 (20.0) 3 (60.0) 1 (20.0) 05 (100) Values in the parenthesis indicate percentage Chanchal Kumar Ghosh et al 4 JAYPEE (20th ed). In: Boon NA, Colledge NR, Walker BR, Hunter JAA (Eds). Edinburgh, Churchill Livingstone, 2006;935-89
  2. Diseases of the liver and biliary system (10th ed). London; Blackwell Science 1997
  3. Liver, biliary tract and pancreatic disease. Clinical medicine (5th ed). Edinburgh: WB Saunders 2002; 335-404
  4. Immunology of the healthy liver: Old questions and new insights. Gastroenterology 2001; 120:250-60
  5. The liver as a site of T-cell apoptosis: Graveyard or killing field? Immunol Rev 2000;174:47-62
  6. Predictive factors for early aspiration in liver abscess. World J Gastroenterol 2008;14: 2089-93
  7. Pattern of hepatomegaly in Jordanians. Ann Trop Med Parasitol 1985;79:443-48
  8. Primary liver cancer: Worldwide incidence and trends. Gastroenterology 2004;127(5 Suppl 1): S5-16
  9. Budd-Chiari syndrome: Etiology, pathogenesis and diagnosis. World J Gastroenterol 2007;13: 2693-96
  10. Hydatid disease: An overview. The ORION Medical Journal 2004;17:144-45
  11. Amebic liver abscess. Southern Medical Journal 2004;97:673-82
  12. Calcified constrictive pericarditis manifested by isolated hepatomegaly. Arch Fr Pediatr 1979;36:696-98
  13. Isolated tuberculous hepatic abscess in a non-immunocompromised patient. J Postgrad Med 2000; 46:108-09
  14. Prognostic factors of hepatocellular carcinoma (HCC). Bangladesh Journal of Medicine 2002;13:26-28
  15. A retrospective study on the coexistence of hydatid cyst and aspergillosis, Int J Infect Dis 2007.
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