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VOLUME 9 , ISSUE 1 ( January-June, 2019 ) > List of Articles

REVIEW ARTICLE

Update on Liver Transplantation: What is New Recently?

Sinan Akosman, Merve Gurakar

Keywords : Direct-acting antiviral drugs, Donor pool, Highly active antiretroviral therapy, Liver transplantation, Scoring system, Severe alcoholic hepatitis

Citation Information : Akosman S, Gurakar M. Update on Liver Transplantation: What is New Recently?. Euroasian J Hepatogastroenterol 2019; 9 (1):34-39.

DOI: 10.5005/jp-journals-10018-1293

License: CC BY-NC 4.0

Published Online: 01-09-2019

Copyright Statement:  Copyright © 2019; The Author(s).


Abstract

Liver transplantation (LT) is an evolving area of medicine for the treatment of certain types of malignancies and acute and chronic liver failures. Since the topic is evolving, new literature is increasingly available. In recent years, with the emerging potent antiviral therapies, hepatitis C virus-infected patients have successful patient and graft survival outcomes. Even human immunodeficiency virus (HIV) positive patients previously contraindicated for organ transplantation are transplanted with comparable outcomes. With increasing demand for LT, the shortage of the donor pool became the rate limiting factor in this hopeful treatment. To overcome waitlist mortality and expand the donor pool, scoring systems have been modified and organs from HIV and/or hepatitis C infected donors are now accepted, under certain circumstances. The new literature also questions the 6-month alcohol abstinence rule for the transplantation of alcoholic liver disease (ALD), in light of early transplantation results from severe alcoholic hepatitis (SAH) trials.

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