Euroasian Journal of Hepato-Gastroenterology

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VOLUME 3 , ISSUE 2 ( July-December, 2013 ) > List of Articles

ORIGINAL ARTICLE

Cancer Antigen-125 is Specifically Associated with Ascites and has no Relation with Liver Function in Liver Cirrhosis

Mohammed Ali Chowdhury, Xiubin Zhang, Wei Han

Citation Information : Chowdhury MA, Zhang X, Han W. Cancer Antigen-125 is Specifically Associated with Ascites and has no Relation with Liver Function in Liver Cirrhosis. Euroasian J Hepatogastroenterol 2013; 3 (2):108-110.

DOI: 10.5005/jp-journals-10018-1076

License: CC BY-NC 4.0

Published Online: 01-07-2013


Abstract

Background: Cancer antigen-125 (CA-125) is a high molecular weight glycoprotein used as a marker for ovarian carcinoma. But its involvement is also observed in many benign conditions particularly in liver cirrhosis and ascites. However, the reason behind it remains unclear. Materials and methods: A total of 53 patients with liver cirrhosis, Budd-Chiari syndrome and tuberculous peritonitis were enrolled in this study. The degree of ascites was graded to into mild, moderate and severe. CA-125 levels of all the patients were measured along with other liver parameters. Results: No association was observed between CA-125 levels of liver cirrhosis patients and parameters of liver function tests. All the patients with ascites had elevated level of CA-125, whereas most of the patients without ascites had CA-125 levels under the normal range. However, the levels of CA-125 were without ascites (p < 0.05). Conclusion: The elevation of CA-125 in liver cirrhosis may be related to ascites and not dependent on parameters of liver dysfunction. Therefore, CA-125 may be used as a predictor of ascites in patients with liver cirrhosis.


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