Euroasian Journal of Hepato-Gastroenterology
Volume 10 | Issue 2 | Year 2020

Artificial Intelligence in Gastrointestinal Endoscopy in a Resource-constrained Setting: A Reality Check

Prajna Anirvan1, Dinesh Meher2, Shivaram P Singh3

1–3Department of Gastroenterology, SCB Medical College, Cuttack, Odisha, India

Corresponding Author: Shivaram P Singh, Department of Gastroenterology, SCB Medical College, Cuttack, Odisha, India, Phone: +91 6712505466, e-mail:

How to cite this article: Anirvan P, Meher D, Singh SP. Artificial Intelligence in Gastrointestinal Endoscopy in a Resource-constrained Setting: A Reality Check. Euroasian J Hepato-Gastroenterol 2020;10(2): 92–97.

Source of support: Nil

Conflict of interest: None


Artificial intelligence (AI) is being increasingly explored in different domains of gastroenterology, particularly in endoscopic image analysis, cancer screening, and prognostication models. It is widely touted to become an integral part of routine endoscopies, considering the bulk of data handled by endoscopists and the complex nature of critical analyses performed. However, the application of AI in endoscopy in resource-constrained settings remains fraught with problems. We conducted an extensive literature review using the PubMed database on articles covering the application of AI in endoscopy and the difficulties encountered in resource-constrained settings. We have tried to summarize in the present review the potential problems that may hinder the application of AI in such settings. Hopefully, this review will enable endoscopists and health policymakers to ponder over these issues before trying to extrapolate the advancements of AI in technically advanced settings to those having constraints at multiple levels.

Keywords: Artificial intelligence, Automated detection, Computer-aided detection, Deep learning, Developing countries, Lesion detection, Health resources, Health services accessibility.

“Good afternoon… gentlemen. I am a HAL 9000… computer. I became operational at the H.A.L. plant [voice becomes lower & slower] in Urbana, Illinois… on the 12th of January 1992. [voice becomes even more lower & slower] My instructor was Mr. Langley… and he taught me to sing a song. If you’d like to hear it, I can sing it for you.”

— HAL 9000 (2001: A Space Odyssey)


Artificial intelligence (AI), a milestone in humankind’s scientific achievements, is an application of computer science based on mathematical logic that utilizes computers to imitate learning, memorizing, and analytical reasoning—attributes traditionally associated with human intelligence and cognition.1 The idea of AI is not new. We find references in fictional characters—Mary Shelly’s Frankenstein and Arthur Clarke’s HAL 9000 being two fine examples. The mathematician Alan Turing is generally credited with conceptualizing AI. Artificial intelligence as a discipline of research came into being in 1956 when John McCarthy coined the term “Artificial Intelligence.”2 In healthcare, AI found its first application in the domain of diagnostics as a medical diagnostic decision support (MDDS) system.3 Research in the sixth and seventh decades of the last century resulted in the advent of Dendral, the first program to solve problems.4 Although originally it was meant to be applied in organic chemistry, it laid the groundwork for another system, MYCIN, which was a very significant advancement in the use of AI in healthcare.5 In 1969, De Dombal et al. designed a very effective MDDS system for clinical diagnosis.6 Soon enough, MDDS systems were being applied in multiple disciplines: forensic medicine, internal medicine, pathology, radiodiagnosis, and psychiatry. In the days to come, AI technology is envisaged to play a decisive role in diagnosis and treatment, maintenance of health records, and overall functioning of healthcare systems including diagnosis, treatment, patient care, and other upcoming areas in medicine.7 Gastroenterology is one such branch where clinical decision making and treatment are driven by complex endoscopic procedures, maneuvers, and visual identification-cum-interpretation that require a lot of technical skill and expertise. Clinicians, in gastroenterology, come across huge amounts of data and a myriad of endoscopic images. This is where AI can be used to aid gastroenterologists in endoscopic diagnosis, image analysis, screening of malignancies and other lesions, and also in developing prognostic models.


Machine learning (ML) and deep learning (DL) can be considered subsets of AI (Fig. 1). Machine learning, an elemental concept in AI ever since the inception of the discipline, can be described as the study of computer algorithms, which over a period of time through training and practice, improve automatically.8 Based on sample data, otherwise called “training data,” ML algorithms devise mathematical models which makes it possible to predict and take decisions without explicit programming. Machine learning is again subdivided into supervised learning and unsupervised learning. In the former, the computer is presented with sample inputs along with the outputs that are desired and are taught the general rule of mapping these inputs to outputs. In the latter, the learning algorithm is left to itself to recognize a structure in its input sample. Predictive models are fashioned by the supervised ML algorithm which allows new inputs to be mapped to outputs.9 Artificial neural networks (ANN) are supervised models quite akin to the organizational structure of the human central nervous system. Neurons are computing units and are interconnected to form a network. From the input layer, a signal traverses through numerous hidden layers en route to the output layer. ANN training encompasses separating the data into a “training set” to define the network architecture and a “test set” to evaluate the ability of ANN to predict the desired output. The quest for improved performance has resulted in the development of increasingly complex neural networks, leading to the concept of DL.10 Deep learning uses multiple layers to progressively extract features of a higher-level from the raw input. A deep neural network (DNN) consists of multiple consecutive filters that enable the automatic detection of important characteristics of input data. However, for improved performance, an enormous amount of labeled training data is required which has led to the combining of DL with reinforcement learning principles.11 An example of the use of the application of DL technology is the training of a deep convolutional neural network (CNN) on 129,450 dermatological images consisting of 2,032 different skin disorders the performance of which was comparable to 21 board-certified dermatologists in differentiating keratinocyte carcinomas from benign seborrheic keratosis and malignant melanomas from benign nevi.12 Figure 2 depicts a diagrammatic representation of the concept of DL.

Fig. 1: ML and DL—subsets of AI

Fig. 2: Deep learning—a diagrammatic representation


The applications of AI in the various domains of GI endoscopy are manifold. A computer algorithm trained to perform specific functions like recognizing or characterizing defined lesions lies at the heart of AI. We summarize here the major areas where the application of AI has been found to be useful both for diagnostic and prognostic purposes.

Image Analysis

Globally, GI malignancies account for 26% of cancer incidence and 35% of cancer-related mortality.13 In 2018, the number of new cases of GI cancer worldwide was 4.8 million while cancer-related deaths amounted to 3.4 million.13 In a bid to increase the rate of detection of gastrointestinal neoplasms and strengthen screening programs, accurate endoscopic examination and proper differentiation of benign from malignant lesions are essential. As previously discussed, training of a computer algorithm is performed using ML by exposing it to training elements, for example, a huge number of predefined video frames depicting various polyps. The algorithm aids conventional endoscopy by extracting and analyzing specific features: the topological pattern of the polyp surface, variation in color, microvasculature, or appearance under narrow-band imaging (NBI), high-magnification, and endocystoscopy, which translates into enhanced and improved quality of lesion detection and prediction of diagnosis.14 Subsequently, a different test database is employed to validate this algorithm. A fine example of such an application is the demonstration by Horie et al. that diagnosis of esophageal cancer could be made using CNN trained with 8,428 images obtained from conventional endoscopy that included white-light images (WLIs) and narrow-band images (NBIs).15 The sensitivity of esophageal cancer detection was 95%, and even small malignancies of <10 mm could be detected. Besides, superficial esophageal cancer could also be differentiated from advanced malignancy with 98% accuracy.15 In addition to the detection of lesions, the characterization of the lesion has also been done with the help of AI. Application of the CNN system to assess the invasive depth of carcinoma stomach using conventional endoscopic images by Zhu et al. demonstrated high accuracy (89.2%) and specificity (95.6%) which was considerably better compared to experienced endoscopists.16 The results of AI application in the detection and characterization of colonic polyps have also been very encouraging. A CNN model by Urban et al. resulted in real-time polyp detection with an AUROC of 0.991 and 96.4% accuracy.17 Capsule endoscopy, despite providing a means to evaluate and explore small bowel lesions has disadvantages, such as the low quality of images generated and the fact that interpretation of images is highly subjective. Here too, CNN has shown immense promise. In a study by Leenhardt et al., a model to detect GI angiectasia designed using CNN demonstrated improved performance with 100% sensitivity, 96% specificity, 96% PPV, and 100% NPV.18 Application of DL in WCE has also been shown to facilitate detection of the bleeding source from the small bowel. Methods in Computer-Aided Detection (CADe) that have evolved have a likelihood of being affected by movements of the camera, optical disturbances pertaining to light reflection and focus of the lens, variability in the morphology of lesions, and distractors like feces, bubbles, etc.19 To overcome these barriers, CADe systems are being developed where context information is utilized and nonpolypoid lesions or structures are removed from the analysis and shape information is utilized to aid in polyp localization. As a further modification and advancement to this technique, real-time polyp detection modalities on larger colonoscopy image databases are also coming up. Even in Helicobacter pylori infection diagnosis, AI has been shown to be helpful. A CNN model was developed by Itoh et al. to aid in recognition of H. pylori infection which demonstrated encouraging results with a sensitivity of 86.7% and specificity of 86.7%.20 Figure 3 shows the process of image analysis using AI in endoscopy.

Fig. 3: Image analysis using AI

Optical Biopsy

The next step after lesion detection is to assess its nature, which traditionally requires a tissue biopsy. However, computational analysis, otherwise called computer-aided diagnosis (CADx), may assist in the prediction of histology even without a tissue biopsy. Optical biopsy can diagnose adenoma in situ and enable early resection obviating the need for unnecessary histopathologic examination.21 Narrow-band imaging and chromoendoscopy are also subject to considerable interobserver and intraobserver variability. Using CADx modalities may help decrease interobserver variance, increase standardization, and make possible more extensive adoption by nonexperts in the field.22 CAD-aided endocytoscopy has been developed that makes use of nuclear segmentation and feature extraction to assist in pathologic classification (i.e., differentiating among non-neoplastic, adenomatous, and malignant lesions).23

Diagnosis Making and Prediction of Prognosis

Apart from the utility of AI in image analysis, various ML models have demonstrated encouraging results in making diagnosis and forecasting prognosis. In stark contrast to the human brain which has limited capabilities in its ability to handle large volumes of data, ANN has the ability to analyze such complex datasets and handle complicated interactions among clinical, environmental, and demographic variables. An ANN model has been developed which can diagnose gastroesophageal reflux disease using just 45 clinical variables extracted from 159 cases with 100% accuracy.24 In another study, recognition of atrophic gastritis was done merely by using clinical and biochemical variables from 350 outpatients with the help of ANNs and linear discriminant analysis with great accuracy.25

In prognostication, too, Sato et al. designed an ANN model to predict 1-year and 5-year survival rates based on 418 patients with carcinoma esophagus. Compared to conventional linear discriminant analysis, it yielded greater accuracy.26 In another study concerning prognostication utilizing ANN, Das et al. made a comparison between ANN performance and a scoring system termed “BLEED” which had been validated earlier. This study revealed significantly greater predictive accuracy for several prognostic indicators in the ANN model, especially mortality (87% vs 21%), recurrent bleeding (89 vs 41%), and the requirement for therapeutic intervention (96 vs 46%).27 Further evidence of the utility of ANN is provided in the study by Rotondano et al. in which the Rockall score was compared to an ANN model using 2380 patients to predict mortality in nonvariceal upper gastrointestinal bleeding.28 This ANN model demonstrated greater sensitivity, specificity, and accuracy compared to the complete Rockall score.28


AI Cost-effectiveness and Economic Impact: Blue are the Hills that are Far Away?

The application of AI in gastroenterology and GI endoscopy, in particular, promises a lot in the days to come. Having said that, it is important to take note of the fact that not many researchers have looked into the economic aspect of AI. In the era of value-based healthcare we are living in, and also because of the high share of the healthcare industry in the overall economy, economic impact assessment is of increasing importance.29 This assumes even greater significance when applying such technology in resource-constrained settings. This, therefore, warrants proper analyses vis-à-vis cost-effectiveness which needs to be optimized in a resource-constrained setting. The AI application has been widely touted to drastically slash healthcare expenditures and costs. However, AI application in a field like gastroenterology, especially gastrointestinal endoscopy in a resource-constrained setting and its economic impact warrants close scrutiny.

For rural clinics without physicians in India, a computer-assisted diagnostic system, early detection and prevention system (EDPS) was developed. Appropriate guidance and recommendations for nurses and other paramedical staff were provided through this system. The overall rate of consistency between physicians and EDPS was found to be 94% based on 933 patients in a study at the Kempegowda Institute of Medical Science in Bangalore, India.3 Also, patient responses were found to be positive in another study, as patients believed that the computer-based system was superior and there was better in-depth interaction with them compared to healthcare personnel.30 Studies and reports from sub-Saharan Africa and China have also reported similar findings.31,32 Thus, medical AI technology has been envisaged to improve upon the efficiency of doctors and healthcare service quality, bring about a reduction in medical costs, and also to train nurses and paramedical health workers in areas that lack doctors, thus greatly reducing healthcare costs.3

While the above findings may look very encouraging, a closer look at the healthcare system in a country like India, a “developing” country with multiple constraints in its healthcare system would put things in perspective. With its resource-constrained settings, despite healthcare being a growing industry, valued at nearly $40 billion,33 there are challenges in ensuring equitable healthcare to all. A major challenge is that healthcare spending in India is largely out of pocket, with almost 70% of hospitals and 40% of hospital beds being private.33 Healthcare in India has come a long way since independence and has had remarkable success in various important health indices. However, there remains much to be done with palpable weaknesses in organization, funding, and provision of health services.34 Health insurance is, to a large extent, private, and the poor have limited access to private care. Healthcare expenditure remains at only 4.1% of gross domestic product (GDP), and there is a huge disparity between rural and urban regions in India as regards provisioning of resources.33

Employment State Insurance Scheme (ESIS) and Central Government Health Scheme (CGHS) are two major state health insurance schemes in India catering to factory workers and employees of the central government, respectively.35 The Government of India has initiated other national health insurance schemes like the Rashtriya Swasthya Bima Yojana, Universal Health Insurance Scheme, Aam Aadmi Bima Yojana, Janashree Bima Yojana, and very recently, the Ayushman Bharat scheme. However, despite attempts to expand social healthcare insurance, a large informal sector, inadequacies in understanding solidarity-based insurance, lack of data on costing, free and unregulated private market, and low standards of public healthcare delivery have complicated things.36 In other developing countries too, the narrative is more or less the same, poor spending on public health, inadequate health insurance, restricted benefit packages, the paucity of health professionals and facilities, deficiencies in training of health workers, and transportation difficulties had resulted in poor quality of healthcare in the rural areas.37

Looking at the advancement of AI technology over the years, and the application of such technology in various aspects of healthcare, it can be extrapolated that for AI applications in the various domains of gastroenterology, certain prerequisites are essential. Firstly, an AI-based clinical decision support system that is both practical and economical must be in place. This system should focus primarily on common gastrointestinal disorders and diseases that are amenable to screening programs. Secondly, the affordability of such a model must be kept in mind, considering the healthcare structure of developing countries. Thirdly, the infrastructure needed for procuring and maintaining the facility has to be developed. For example, in addition to endoscopes, there has to be an adequate number of computers (desktops and laptops), appropriate software, uninterrupted power supply, etc. There has to be proper connectivity for the transmission of information. And most importantly, one of the basic prerequisites is the training of doctors, healthcare workers, and other personnel in the different modalities of AI application.3

Although there are no studies that have directly looked into the cost-effectiveness of AI in GI endoscopy in a resource-constrained setting, a study by Dalaba et al. which investigated the financial aspects regarding the implementation of a computer-assisted clinical decision support system for antenatal and peripartum care in Northern Ghana can be examined as a test example.38 For each healthcare worker trained, the total financial cost amounted to around $1060 (roughly 68,772.8 INR according to existing exchange rates), of which the cost of equipment accounted for the highest proportion of the financial cost. Cost pertaining to personnel accounted for 28.6%, 12.1% for meeting and training, cost relating to transportation accounted for 8.5%, and other costs amounted to16.8%.38 The same can be said for the various domains of gastroenterology and GI endoscopy in which AI is supposed to play a major role. While optical biopsy and image analysis sound fine, the cost that would be incurred for these techniques remains an area of concern. While in developed countries with a well-equipped healthcare model in place this may not be a problem, in poor, rural, and resource-constrained settings, it may aggravate the burdened healthcare system in place. Hence, validation of cost-effectiveness is necessary before developing and designing any such AI program. Reasonable regulations also need to be commissioned by appropriate regulatory authorities while provisions must be made for reimbursement before integrating AI technology in the field of GI endoscopy. In gastroenterology setups in government-run medical colleges and hospitals which cater to the bulk of the population, without addressing the problems of health insurance, equitable healthcare, and maintenance of equipment, AI application may well turn out to be the white elephant of GI endoscopy.

Technical Concerns

In developing countries like India, the GI endoscopy centers both in government hospitals and private centers are manned, in addition to endoscopists, by nurses and technicians. The AI programs that are designed are meant for adequately trained doctors. Without making user-friendly programs and educating the paramedics and healthcare workers, the application of AI will not serve its purpose. To add to this, regional medical AI support centers have to be established that will oversee the entire AI network and will carry out periodic inspection, assessment, and upgradation of the existing system.

The medical colleges and government-run hospitals that have dedicated departments of gastroenterology generally cater to a large population from the rural areas and a huge number of endoscopic procedures are done daily. Often, it is seen that there is a lack of adequate staffing and infrastructure in endoscopy suites and clinicians have to work day in and out under extremes of professional constraints. In such circumstances, the “imposition” of AI-based technology in the field of GI endoscopy might create greater confusion and may turn out to be an additional burden, ultimately failing to live up to its primary purpose.

Professional Issues: Gastroenterologists Reduced to Mere Technicians!

In addition to the technical training and know-how that has to be imparted to physicians, regular system upgrades are also required to keep pace with the latest advances. It has been shown that there has been disagreement among healthcare providers with the recommendations made by medical AI devices.31 Therefore, regular training and assessment of physicians and healthcare providers to keep them abreast of the latest advances in technology are essential to prevent misuse and mismanagement of AI systems.

Some reports have shown that AI-related technologies in medicine could impair the efficacy of patient consultation which may lead to anomalous situations, such as missing out important clinical signs while focusing more on technological appliances.39 While a machine-based intelligence system can definitely outperform a human brain in terms of compiling data and interpreting it, certain features exclusively “human” are an integral part of the doctor and patient relationship. Therefore, in developing countries that are technically backward and are still largely dependent on the traditional face-to-face doctor–patient interaction, this might have a negative bearing on the overall doctor and patient relationship. In a bid to promote AI, the gastroenterologist runs the risk of being reduced to a mere automaton, relying solely on the report generated by AI, which in turn, might prove costly to patients and the healthcare system in general.

Safety and Accountability: Everybody’s Responsibility is Nobody’s Responsibility?

It has been argued by proponents of AI technology that it has the ability to cause reductions in unwarranted variations and improve the standards of quality of all endoscopists to the very best, an example being the improvement of detection rates of adenoma or carcinoma while performing colonoscopy. However, it can also be equally argued that AI is not fool-proof and mistakes could occur. The inability of algorithms to arrive at decisions based on data fed into the system ignoring contextual information and bypassing clinical judgment might prove disastrous.40 Also, automation bias could compound algorithmic errors, where AI decisions might be favored by clinicians even though these are incorrect.41 The problem of accountability regarding medical decisions involving AI has been a subject of intense debate. If, during AI-aided endoscopic image analysis, a lesion is wrongly deemed malignant and treatment regimens are instituted accordingly, who would take the responsibility? Should the endoscopist or the oncologist or the hospital or institution bear the responsibility? Or should it be the one who devised the algorithm, the vendor responsible for the deployment, or the organization providing the training data?42 In such cases concerning legal and ethical problems, who would be held accountable? In resource-constrained settings of developing countries, with a large chunk of the population unaware of the ethical issues of advanced technology in medicine, indiscriminate application of AI without addressing these issues might cause immense harm to unsuspecting patients and reduce them to mere guinea pigs in an experimental cauldron of GI endoscopy.

Data Sourcing and Validation in Real-world Setting

Despite the reported high level of performance in the various studies concerning AI application in endoscopy, there remain several questions as the various proposed models have been tested only in research settings. In a “real-world” setting, for example, studying the prevalence of colorectal polyps in an Indian population with its inherent enormous amount of diversity, these very models may display different behavior when applied and have every chance of poor generalization to different populations and regions. Therefore, rigorous validation is essential to design an algorithm that can be used in a clinical setting. This includes both internal and external validation along with validation in a prospective clinical trial which, again, is time-consuming and expensive.43

Figure 4 shows the potential problems in implementing AI in endoscopy in a resource-constrained setting.


The AI-based application holds immense promise in various fields of GI endoscopy. It has the potential to revolutionize the way endoscopies are being done and interpreted. Advances in deep learning techniques will definitely bring about a sea change in the realm of image analysis and will push the borders of the existing methods of diagnosis and prognosis. While in developed countries, perhaps the revolution has already begun, in resource-constrained settings, implementation of AI in “real-world” clinical practice overcoming economic, social, and ethical barriers will prove to be a Herculean task. Simply extrapolating the results obtained from experiences in technologically advanced settings to resource-constrained environments will not yield favorable results. Without developing healthcare infrastructure, initiating better healthcare insurance schemes, and engaging in rigorous clinical studies, AI-based technology in GI endoscopy may probably be reduced to something of only ornamental significance. To properly utilize the immense power of AI, there has to be investment aimed at developing the infrastructure along with the implementation of government policies that promote innovation while taking into account cost analysis and patient safety.42

Fig. 4: Potential problems in implementing AI in endoscopy in a resource-constrained setting


In his article “The Implausibility of Intelligence Explosion” Google engineer François Chollet remarks that artificial intelligence, and for that matter all intelligence, is “fundamentally situational”.44 A computer algorithm’s intelligence in the endoscopic interpretation of a lesion (benign vs malignant) concerns solving the problem associated with applying that algorithm to analyze the specific data fed into it, merely adaptive to the situation it is in. It has no knowledge of the patient’s vitals, functional status, and emotional state. It simply is not its concern. In a typical “real-world” resource-constrained setting, where despite a lack of infrastructure and below-average healthcare standards, a gastroenterologist by virtue of his/her clinical acumen, humane approach, and endoscopic skills succeeds in providing reasonably affordable patient care, it would be worthwhile to remind ourselves that imposing AI, without taking into account the existing problems, could turn into a Frankenstein because of sheer human impudence and irrationality.


This work was partially supported by a grant from the Kalinga Gastroenterology Foundation, Cuttack, India.


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