Euroasian journal of hepato-gastroenterology

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VOLUME 9 , ISSUE 1 ( January-June, 2019 ) > List of Articles


Familial Pancreatic Cancer at Elderly Siblings in Japan

Yohei Kashimoto, Satoshi Takeji, Shin Yamamoto, Keitaro Kawasaki, Takatoshi Murakami, Kenji Bando, Norio Horiike, Masanori Abe, Teru Kumagi

Keywords : Cancer risk, Elderly siblings, Familial pancreatic cancer

Citation Information : Kashimoto Y, Takeji S, Yamamoto S, Kawasaki K, Murakami T, Bando K, Horiike N, Abe M, Kumagi T. Familial Pancreatic Cancer at Elderly Siblings in Japan. Euroasian J Hepatogastroenterol 2019; 9 (1):52-54.

DOI: 10.5005/jp-journals-10018-1296

License: CC BY-NC 4.0

Published Online: 01-09-2019

Copyright Statement:  Copyright © 2019; The Author(s).


Two female siblings aged 87 and 90 years were clinically diagnosed as pancreatic cancer by abdominal ultrasonography and abdominal contrast-enhanced CT. Pancreatic cancer of these patients was confirmed during the autopsy. Both patients shared risk factors of pancreatic cancer; old age, diabetes, and passive smoking. Strong family history of pancreatic cancer was found in these two patients as their father and younger brother were also suffering from this cancer. The present study seems to report two eldest cases of familial pancreatic cancer in siblings.

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  1. Matsubayashi H, Takaori K, et al. Familial pancreatic cancer: Concept, management and issues. World J Gastroenterol 2017; 23(6): 935-948.
  2. James TA, Sheldon DG, et al. Risk factors associated with earlier age of onset in familial pancreatic carcinoma. Cancer 2004;101:2722-2726.
  3. Ghadirian P, Liu G, et al. Risk of pancreatic cancer among individuals with a family history of cancer of the pancreas. Int J Cancer 2002;97:807-810.
  4. (March 2018; Accessed: November 18, 2018)
  5. James TA, Sheldon DG, et al. Risk factors associated with earlier age of onset in familial pancreatic carcinoma. Cancer 2004;101:2722-2726.
  6. Lin Y, Tamakoshi A, et al. Descriptive Epidemiology of Pancreatic Cancer in Japan. J Epidemiol; 1998;8:52-59.
  7. Jacobson SD, Alberts SR, et al. Pancreatic cancer in the older patient. Oncology 2001;15:926-937.
  8. Bellevue O, Johnson B, et al. Pancreatic cancerin the very elderly patients: Challenges and solutions. Surg Res Open J 2016;3:4-12.
  9. MacDermott RP, Kramer P. Adenocarcinoma of the pancreas in four siblings. Gastroenterology 1973;65:137-139.
  10. Friedman JM, Fialkow PJ. Carcinoma of the pancreas in four brothers. Birth Defects Orig Artic Ser 1976;12:145-150.
  11. Reimer RR, Fraumeni JF Jr, et al. Pancreatic cancer in father and son. Lancet 1977; 2:747.
  12. NmDat, Sontag SJ. Pancreatic carcinoma in brothers. Ann Intern Med 1982;97(2):282.
  13. Ghadirian P, Simard A, et al. cancer of the pancreas in two brothers and one sister. Int J Pancreatol 1987;2:137-139.
  14. Deborah E, Haeger L, et al. Familial pancreatic adenocarcinoma in three generations. A case report and a review of the literature. Cancer 1987;59:1661-1664.
  15. Petersen GM. Familial pancreatic cancer. Semin Oncol. 2016; 43:548- 553.
  16. Chang MC, Wu CH, et al. Pancreatic cancer screening in different risk individuals with family history of pancreatic cancer - a prospective cohort study in Taiwan. Am J Cancer Res 2017;7:357-369.
  17. Evans JP, Burke W, et al. Familial pancreatic adenocarcinoma: association with diabetes and early molecular diagnosis. J Med Genet 1995;32:330-333.
  18. Klein AP, Brune KA, et al. Prospective risk of pancreatic cancer in familial pancreatic cancer kindreds. Cancer Res 2004;64:2634-2638.
  19. Dergham ST, Dugan MC, et al. Relationship of family cancer history to the expression of p53, p21WAF-1, HER-2/neu, and Kra mutation in pancreatic adenocarcinoma. Int J Pancreatol 1997;21:225-234.
  20. Brune KA, Lau B, et al. Importance of age of onset in pancreatic cancer kindreds. J Natl Cancer Inst 2010;102:119-126.
  21. Matsubayashi H, Maeda A, et al. Risk factors of familial pancreatic cancer in Japan: current smoking and recent onset of diabetes. Pancreas 2011;40:974-978.
  22. Shibata H, Komura S, et al. In vivo reprogramming drives Kras-induced cancer development. Nat Commun 2018;9:2081.
  23. Frohlich E, Wahl R. Thyroid autoimmunity: Role of anti-thyroid antibodies in thyroid and extra-thyroidal diseases. Front Immunol 2017;8:521.
  24. Goldman MB, Monson RR, et al. Cancer mortality in women with thyroid disease. Cancer Res 1990;50:2283-2289.
  25. Morizane C, Kitano M, et al. Japanese familial pancreatic cancer registry with the aim to early detection of pancreatic cancer. Suizou 2017;32:23-29. (in Japanese with English Abstract)
  26. Takai E, Yachida S, et al Germline mutations in Japanese familial pancreatic cancer patients. Oncotarget 2016;7:74227-74235.
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