Citation Information :
Duzenli T, Tanoglu A, Akyol T, Kara M, Yazgan Y. Drug-induced Liver Injury Caused by Phenprobamate: Strong Probability Due to Repeated Toxicity. Euroasian J Hepatogastroenterol 2019; 9 (1):49-51.
Drug-induced liver injury (DILI) is an important cause of morbidity and mortality. DILI can even cause acute liver failure and the need for liver transplantation. Identifying DILI may be particularly difficult because it is actually an exclusion diagnosis and individuals are usually exposed to several drugs during a lifetime. Causality assessment methods are needed for objective diagnosis. The most common methods are; updated Roussel Uclaf causality assessment method (RUCAM), Narenjo adverse drug reaction probability scale and Maria and Victorino (M&V) causality assessment scale. Phenprobamate is a widely used muscle relaxant. Herein we report a rare case of repeated DILI caused by phenprobamate and review the objective diagnostic process for hepatotoxicities. Physicians should be aware of the potential adverse effects of this drug, including hepatotoxicity.
Tujios SR, Lee WM. Acute liver failure induced by idiosyncratic reaction to drugs: Challenges in diagnosis and therapy. Liver Int 2017 Aug 3.
Raschi E, De Ponti F. Drug-induced liver injury: Towards early prediction and risk stratification. World J Hepatol 2017;9(1):30-37.
Andrade RJ, Ortega-Alonso A, et al. Drug-Induced Liver Injury Clinical Consortia: a global research response for aworldwide health challenge. Expert Opin Drug Metab Toxicol 2016;12(6):589-593.
Danan G, Teschke R. RUCAM in drug and herb induced liver injury: The Update. Int J Mol Sci 2015;17(1). pii: E14.
Naranjo CA, Busto U, et al. A method for estimating the probability of adverse drug reactions. Clin Pharmacol Ther 1981;30(2): 239-245.
Maria VA, Victorino RM. Development and validation of a clinical scale for the diagnosis of drug-induced hepatitis. Hepatology. 1997 Sep;26(3):664-669.
Emet M, Aslan S, et al. Plasmapheresis is useful in phenprobamate overdose. Am J Emerg Med 2009;27(5):626.e1-e2.
Tasdemir HA, Yildiran A, et al. Haemoperfusion may be useful in phenprobamate and polypharmacy intoxication of paediatric patients. Nephrol Dial Transplant.2002;17(5):941.
Tulunay FC, Onaran HO, et al. Pharmacokinetics of phenprobamate after oral administration to healthy subjects. Arzneimittelforschung 1998; 48:1068-1071.
Demir B, Demir Y, et al. Phenprobamate dependence: a case report. Addict Behav. 2015;45:232-233.
Sengul BC, Sengul C, et al. Is Prescription Drug Abuse in Prisons Changing? A Preliminary Study with Prison Doctors. J Depend 2015;16(3):113-118.
