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VOLUME 9 , ISSUE 1 ( January-June, 2019 ) > List of Articles


Association of Cirrhosis and Cardiomyopathy

Burcu Sezgin, Cigdem Cindoglu, Ahmet Uyanikoglu, Necati Yenice

Keywords : Cardiomyopathy, Cirrhosis, Pro-BNP, Troponin-I, QT prolongation

Citation Information : Sezgin B, Cindoglu C, Uyanikoglu A, Yenice N. Association of Cirrhosis and Cardiomyopathy. Euroasian J Hepatogastroenterol 2019; 9 (1):23-26.

DOI: 10.5005/jp-journals-10018-1291

License: CC BY-NC 4.0

Published Online: 01-09-2019

Copyright Statement:  Copyright © 2019; The Author(s).


Introduction: We investigated association of pro-BNP, troponin-I, electrocardiography (ECG) and echocardiography (ECHO) during diagnosis and identification of cirrhotic cardiomyopathy in cirrhotic patients. Materials and methods: Patients were divided into three groups as; compensated cirrhotic patients (group 1, n= 30), decompensated cirrhotic (group 2, n = 30) and control group (group 3, n = 30). ECHO, and ECG were performed, and troponin-I and levels of pro-BNP were analyzed. Results: Average age of group 1 was 46.36 ± 16 years (range 19–86), 60% were female; group 2 was 57.03 ± 13.54 years (range 22–89), 56% female; and group 3 was 49.13 ± 0.95 years (range 18–80), 56% female. A significant increase in QTc was detected in compensated cirrhotic patients compared to the control group (p <0.05). Pro-BNP levels were significantly higher (p <0.05) in the compensated cirrhotic group compared to the control group. The levels of pro-BNP were also significantly higher in the decompensated cirrhotic group compared compensated cirrhosis group and control group (p <0.001). Conclusion: The increase of pro-BNP levels with severity of the disease in cirrhotic patients and the prolongation of QTc interval supports an association between these factors with cardiomyopathy.

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