The results of antibiotic prophylaxis in 148 patients with destructive acute surgical sicknesses of abdominal cavity being urgently operated in the Republican hospital of Baku city from 2011 to 2016 were analyzed. Sixty-five patients were in the basic group which had got as preoperative antibiotic prophylaxis 120-hour course of amoxiclav (amoxicillin in combination with clavulanic acid). Eighty-three patients were in the control group who have performed a surgical intervention with pre-operative 120-hour antibiotic prophylaxis by Claforan (cefotaxime) combining with Metrogel (metronidazole). Ýt was showed that applying antibiotic prophylaxis using amoxiclav positively lowered the frequency of as postoperative purulent-septic complications as recurring operations to 8.1%.
Akhundov IT, Ibishov Sh F, Alekperov DA. The endolymphatic immunomodulating therapy in correction of immune status disturbances in patients with peritonitis.//5-th World Congress on Trauma, Shock, Inflammation and Sepsis: Abstr. - Munich, Germany, 2000, p.192.
Bratzler DW, Houck PM. Antimicrobial prophylaxis for surgery: Anadvisory statement from the national surgical infection preventionproject.//Clinical Infectious Diseases.- 2004;38(12):1706-1715.
Mui LM, Ng CSH, Wong SKH, Lam YH, Fung TMK, Fok KL, et al. Optimum duration of prophylactic antibiotics in acute non-perforated appendicitis.//ANZ Journal of Surgery.- 2005;75(6):425-428.
Esposito S, Noviello S, Vanasia A, Venturino P. Ceftriaxone versus Other Antibiotics for Surgical Prophylaxis: A Meta-Analysis.//Clinical Drug Investigation.- 2004;24(1):29-39.
Pratt RJ, Pellowe CM, Wilson JA, Loveday HP, Harper PJ, Jones SR, et al. epic2: National Evidence-Based Guidelines for Preventing Healthcare-Associated Infections in NHS Hospitals in England.//JHosp Infect. -2007;65 Suppl 1:S1- S59.
Weber WP, Marti WR, Zwahlen M, Misteli H, Rosenthal R, Reck S, et al. The timing of surgical antimicrobial prophylaxis.//Ann Surg.-2008;247(6):918-926.
Bratzler DW, Dellinger EP, Olsen KM, Perl TM, Auwaerter PG, Bolon MK, et al. Clinical practice guidelines for antimicrobial prophylaxis in surgery.//Am J Health Syst Pharm.-2013; 70(3):195-283.
David N, Gilbert HF, Chambers GM, Eliopoulos MS. The Sanford Guide to Antimicrobial Therapy//Antimicrobial Therapy.-2015:45st ed.238p.