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VOLUME 7 , ISSUE 2 ( July-December, 2017 ) > List of Articles


Effect of Different Sedation Regimes on Cognitive Functions in Colonoscopy

Perihan Ekmekçi, Gulbanu Erkan, Baturay K Kazbek, Ulku C Köksoy, Güler Doganay, Filiz Tüzüner

Citation Information : Ekmekçi P, Erkan G, Kazbek BK, Köksoy UC, Doganay G, Tüzüner F. Effect of Different Sedation Regimes on Cognitive Functions in Colonoscopy. Euroasian J Hepatogastroenterol 2017; 7 (2):158-162.

DOI: 10.5005/jp-journals-10018-1239

License: CC BY 3.0

Published Online: 01-12-2016

Copyright Statement:  Copyright © 2017; The Author(s).



To compare the effects of propofol/remifentanil and meperidine/midazolam on postprocedure cognitive function.

Materials and methods

A total of 100 American Society of Anesthesiologists (ASA) score I to III patients undergoing elective colonoscopy were taken into the study and divided into two groups. Exclusion criteria were patient refusal, mini mental test (MMT) <26, The Amsterdam Preoperative Anxiety and Information Scale (APAIS) >10, advanced cardiopulmonary or psychiatric disease, chronic alcohol abuse, morbid obesity, and known allergy to study drugs. In group MM, 2 mg midazolam and 20 mg meperidine was given intravenously and additional 1 to 2 mg midazolam and 20 mg meperidine (with a maximum total of 5 mg midazolam and 50 mg meperidine) was given when bispectral index (BIS) was >80. In group RP, 100 μg/kg/minute propofol infusion and 1 μg/kg remifentanil bolus was administered and additional 0.5 μg/kg remifentanil bolus was given when BIS was >80. Observer's Assessment of Alertness/Sedation scale (OAA/S) and Facial Pain Score (FPS) values were recorded. Cognitive function was measured by Trieger Dot Test (TDT) and Digit Symbol Substitution Test (DSST).


The study was concluded with 100 patients. Heart rate was slower and BIS values were lower in group RP throughout the procedure. Blood pressure was lower in group RP without clinical significance. There was no difference concerning recovery time and visual analog scores (VASs). In group MM, TDT scores were higher and DSST scores were lower. Satisfaction was higher in group RP.


Propofol/remifentanil combination is better than meperidine/midazolam combination concerning cognitive function in sedation for colonoscopy.

Clinical significance

The addition of BIS monitorization to evaluate the depth of sedation and the negative effects of midazolam meperidine combination on postprocedural cognitive function.

How to cite this article

Ekmekçi P, Erkan G, Yilmaz H, Kazbek BK, Köksoy UC, Doganay G, Tüzüner F. Effect of Different Sedation Regimes on Cognitive Functions in Colonoscopy. Euroasian J Hepato-Gastroenterol 2017;7(2):158-162.

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