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VOLUME 7 , ISSUE 2 ( July-December, 2017 ) > List of Articles


Psychological Results of 438 Patients with persisting Gastroesophageal Reflux Disease Symptoms by Symptom Checklist 90-Revised Questionnaire

Xia Chen, Ping Li, Fei Wang, Guozhong Ji, Lin Miao, Sihong You

Citation Information : Chen X, Li P, Wang F, Ji G, Miao L, You S. Psychological Results of 438 Patients with persisting Gastroesophageal Reflux Disease Symptoms by Symptom Checklist 90-Revised Questionnaire. Euroasian J Hepatogastroenterol 2017; 7 (2):117-121.

DOI: 10.5005/jp-journals-10018-1230

License: CC BY 3.0

Published Online: 01-08-2018

Copyright Statement:  Copyright © 2017; The Author(s).


Aims and objectives

Gastroesophageal reflux disease (GERD) affects mental state and social activities. On the contrary, mental disorders may also play a crucial role in GERD symptoms. The purpose of the study was to analyze the data of Symptom Checklist 90-Revised (SCL-90-R) questionnaire from patients with persisting GERD and to explore the impact of psychological factors on them.

Materials and methods

The patients accepted SCL-90-R questionnaire survey, following endoscopy, high-resolution manometry (HRM), and ambulatory impedance-pH monitoring. Based on these results, we divided patients into different groups. The result of SCL-90-R was also compared with degree of acid reflux, symptoms, symptom duration, and gender.


The data from 438 patients were analyzed. All patients were divided into reflux esophagitis (RE; 63, 14.38%); nonerosive gastroesophageal reflux disease (NERD; 106, 24.20%); functional heartburn (FH; 123, 28.08%), hypersensitive esophagus (HE; 67, 15.29%), diffuse esophageal spasm (DES; 5: 1.14%), hypertensive (10, 3.42%); weak peristalsis (14, 3.20%); achalasia (50, 11.42%). There were significant differences between different groups regarding depression (DEP), anxiety (ANX), paranoid ideation (PAR), and psychoticism (PSY). The patients with ≥2 years with GERD presented with increased scores in DEP, ANX, and PSY. Women had dramatically higher scores than men in each domain (p < 0.05).


Data have shown that GERD patients exhibit differential levels of psychological symptoms. Long duration of GERD was related to typical plus atypical symptoms and females seem to be more prone to develop psychological disorders.

How to cite this article

Chen X, Li P, Wang F, Ji G, Miao L, You S. Psychological Results of 438 Patients with persisting Gastroesophageal Reflux Disease Symptoms by Symptom Checklist 90-Revised Questionnaire. Euroasian J Hepato-Gastroenterol 2017;7(2):117-121.

  1. Guidelines for the diagnosis and management of gastroesophageal reflux disease. Am J Gastroenterol 2013 Mar;108(3):308-328.
  2. Asia-Pacific consensus on the management of gastro-oesophageal reflux disease: an update focusing on refractory reflux disease and Barrett's oesophagus. Gut 2016 Sep;65(9):1402-1415.
  3. Proton-pump inhibitor therapy in patients with gastroesophageal reflux disease: putative mechanisms of alure. Drugs 2007;67:1521-1530.
  4. Risk of psychiatric disorders following gastroesophageal reflux disease: a nationwide population-based cohort study. Eur J Intern Med 2015 Sep;26(7):534-539.
  5. Quality of life and depression in a cohort of female patients with chronic disease. BMC Surg 2012 Nov;12(Suppl 1):S10.
  6. Mental health and quality of life in patients with chronic otitis media. Eur Arch Otorhinolaryngol 2013 Feb;270(2):521-526.
  7. Clinical study on the correlation between psychogenic dental prosthesis incompatibility, oral stereognosis, and the psychologic diagnostic tools SCL-90-R and CES-D. Int J Prosthodont 2007 Sep-Oct;20(5):538-545.
  8. Psychosocial aspects of the functional gastrointestinal disorders. Gastroenterology 2006 May;130(5):1447-1458.
  9. The management of cancer pain. CA Cancer J Clin 2011 May-Jun;61(3):157-182.
  10. SCL-90: an outpatient psychiatric rating scale—preliminary report. Psychopharmacol Bull 1973 Jan;9(1):13-28.
  11. The SCL-90 and the MMPI: a step in the validation of a new self-report scale. Br J Psychiatry 1976 Mar;128:280-290.
  12. Chicago classification criteria esophageal motility disorders defined in high resolution esophageal pressure topography. Neurogastroenterol Motil 2012 Mar;24(Suppl 1):57-65.
  13. .Ambulatory high-resolution manometry, lower esophageal sphincter lift and transient lower esophageal sphincter relaxation. Neurogastroenterol Motil 2012 Jan;24(1):40-46.
  14. Symptom characteristics and psychosomatic profiles in different spectrum of gastroeso-phageal reflux disease. Gut Liver 2014 Mar;8(2):165-169.
  15. Severe gastro-oesophageal reflux symptoms in relation to anxiety, depression and coping in a population-based study. Aliment Pharmacol Ther 2007 Sep;26(5):683-691.
  16. Comparative analysis between psychological and endoscopic profiles in patients with gastroesophageal reflux disease: a prospective study based on screening endoscopy. J Gastroenterol Hepatol 2006 May;21(5):798-804.
  17. Psychological factors in gastroesophageal reflux disease measured by scl-90-R questionnaire. Dig Dis Sci 2008 Dec;53(12):3071-3075.
  18. Clinical characteristics of asymptomatic esophagitis. J Gastroenterol 2008 Feb;43(1):27-31.
  19. Dyspepsia and IBS symptoms in patients with NERD, ERD and Barrett's esophagus. Dig Dis Sci 2008 May;26(3):243-247.
  20. Prevalence of atypical symptoms and their association with typical symptoms of gastroesophageal reflux in Spain. Eur J Gastroenterol Hepatol 2006 Sep;18(9):969-975.
  21. The relationship between existence of typical symptoms and psychological factors in patients with erosive esophagitis. J Neurogastroenterol Motil 2012 Jul;18(3):284-290.
  22. Gender-associated differences in pulmonary rehabilitation outcomes in people with chronic obstructive pulmonary disease: a systematic review. J Cardiopulm Rehabil Prev 2014 Mar-Apr;34(2):87-97.
  23. Gender medicine: a task for the third millennium. Clin Chem Lab Med 2013 Apr;51(4):713-727.
  24. Psychiatric factors related to sexual functioning in patients with Parkinson's disease. Clin Neurol Neurosurg 2013;115:419-424.
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