Euroasian Journal of Hepato-Gastroenterology

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VOLUME 7 , ISSUE 1 ( January-June, 2017 ) > List of Articles

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Relationship between Hepatitis B Viral Deoxyribonucleic Acid Load and Hepatocellular Carcinoma

Salimur Rahman, Mobin Khan, Muhammad M Hussain, Shahidul Islam, Nooruddin Ahmed

Citation Information : Rahman S, Khan M, Hussain MM, Islam S, Ahmed N. Relationship between Hepatitis B Viral Deoxyribonucleic Acid Load and Hepatocellular Carcinoma. Euroasian J Hepatogastroenterol 2017; 7 (1):111-112.

DOI: 10.5005/jp-journals-10018-1228

License: CC BY 3.0

Published Online: 01-06-2017

Copyright Statement:  Copyright © 2017; Jaypee Brothers Medical Publishers (P) Ltd.


Abstract

Introduction

Hepatitis B virus (HBV) infection is an established cause of hepatocellular carcinoma (HCC) and is associated with poor prognosis. High HBV deoxyribonucleic acid (DNA) load has been identified in HCC and hepatitis B surface antigen-positive patients.

Materials and methods

This study was done in the Department of Hepatology, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh, from January 2006 to December 2007. Thirty patients with HBV infection-related HCC were enrolled. Another 30 patients with HBV-related liver diseases without HCC were analyzed as controls.

Results

The HCC patients had a high viral load (>105 copies/mL), while all of the controls had low (<105 copies/mL) viral load.

Conclusion

It seems that patients with HCC bear high HBV DNA loads in Bangladesh, but the causes underlying this remain to be resolved.

How to cite this article

Hussain MM, Al Mahtab M, Islam S, Ahmed N, Rahman S, Khan M. Relationship between Hepatitis B Viral Deoxyribonucleic Acid Load and Hepatocellular Carcinoma. Euroasian J Hepato-Gastroenterol 2017;7(1):111-112.


  1. Screening for hepatocellular carcinoma. Hepatology 1998 Jan;27(1):273-278.
  2. Factors predicting occurrence and prognosis of hepatitis-B-virus-related hepatocellular carcinoma. World J Gastroenterol 2011 Oct;17(38):4258-4270.
  3. Viral genotypes and associated risk factors of hepatocellular carcinoma in India. Cancer Biol Med 2012 Sep;9(3):172-181.
  4. Early viral suppression predicts good postoperative survivals in patients with hepatocellular carcinoma with a high baseline HBV-DNA load. Ann Surg Oncol 2013 May;20(5):1482-1490.
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