Association of Severity of Helicobacter pylori Infection with Peripheral Blood Neutrophil to Lymphocyte Ratio and Mean Platelet Volume
Mustafa Guclu, A Faruq Agan
Citation Information :
Guclu M, Agan AF. Association of Severity of Helicobacter pylori Infection with Peripheral Blood Neutrophil to Lymphocyte Ratio and Mean Platelet Volume. Euroasian J Hepatogastroenterol 2017; 7 (1):11-16.
To determine the correlation of Helicobacter pylori infection with peripheral blood neutrophil/lymphocyte ratio (NLR) and mean platelet volume (MPV).
Materials and methods
The NLR, MPV, platelets, leukocytes, neutrophils, and lymphocytes were calculated and the differences between groups were investigated.
A total of 199 patients were included in the study. Neutrophil/lymphocyte ratio was statistically lower in H. pylori-positive patients than in H. pylori-negative patients (1.94 ± 0.79 vs 2.67 ± 2.35 respectively, p = 0.04). There was no significant difference between H. pylori-negative patients and H. pylori-positive patients of severe intensity in terms of MPV. However, peripheral blood lymphocytes and platelets were statistically significantly higher in H. pylori-positive patients of severe intensity (lymphocytes 2150 ± 826 vs 2954 ± 2436 respectively, p = 0.000 and platelets 258247 ± 69494 vs 265611 ± 113397 respectively, p = 0.02) compared with H. pylori-negative patients.
A moderate increase in the intensity of H. pylori does not lead to a significant change in MPV as measured by hemogram; however, it gives rise to a statistically significant fall in NLR. Presence of severe H. pylori-positive intensity leads to a statistically significant increase in peripheral blood lymphocytes and platelets compared with H. pylori-negative patients.
How to cite this article
Guclu M, Agan AF. Association of Severity of Helicobacter pylori Infection with Peripheral Blood Neutrophil to Lymphocyte Ratio and Mean Platelet Volume. Euroasian J Hepato-Gastroenterol 2017;7(1):11-16.
Helicobacter pylori and inflammation. Curr Pharm Des 2010;16(38):4225-4236.
Epidemiology of Helicobacter pylori infection. Best Pract Res Clin Gastroenterol 2007;21(2):205-214.
Helicobacter pylori infection causes gastric cancer? A review of the epidemiological, meta-analytic, and experimental evidence. World J Gastroenterol 2006 May;12(19): 2991-2999.
Significant association between serum interleukin-6 and Helicobacter pylori antibody levels among H. pylori-positive Japanese adults. Mediators Inflamm 2013 Dec;2013(12):Article ID 142358, 5 pages.
Increased concentrations of C-reactive protein and IL-6 but not IL-18 are independently associated with incident coronary events in middle-aged men and women: results from the MONICA/KORA Augsburg case-cohort study, 1984–2002. Arterioscler Thromb Vasc Biol 2006 Dec;26(12):2745-2751.
Is there more than C-reactive protein and fibrinogen?: the prognostic value of soluble CD40 ligand, interleukin-6 and oxidized low-density lipoprotein with respect to coronary and cerebral vascular disease. Atherosclerosis 2006 Jul;187(1): 18-25.
Serum levels of high-sensitivity C-reactive protein (hs-CRP) in Helicobacter pylori-infected peptic ulcer patients and its association with bacterial CagA virulence factor. Dig Dis Sci 2009 Dec;54(12):2612-2616.
Interleukin-6 and the acute phase response. Biochem J 1990 Feb;265(3):621-636.
Serum and gastric fluid levels of cytokines and nitrates in gastric disease infected with Helicobacter pylori. New Microbiol 2004 Apr;27(2):139-148.
Impact of C-reactive protein on disease risk and its relation to dietary factors. Asian Pac J Cancer Prev 2007 Apr-Jun;8(2):167-177.
C-reactive protein as a marker for inflammatory bowel disease. Inflamm Bowel Dis 2004 Sep;10(5):661-665.
Extragastrointestinal manifestations of Helicobacter pylori infection; Facts or myth? A critical review. J Dig Dis 2012 Jul;13(7):342-349.
The relationship between diabetes, metabolic syndrome, and platelet activity as measured by mean platelet volume: the National Health and Nutrition Examination Survey, 1999-2004. Diabetes Care 2012 May;35(5):1074-1078.
Association between admission neutrophil to lymphocyte ratio and outcomes in patients with acute coronary syndrome. Am J Cardiol 2008 Sep;102(6):653-657.
Classification and grading of gastritis. The updated Sydney System. International Workshop on the Histopathology of Gastritis, Houston 1994. Am J Surg Pathol 1996 Oct;20(10):1161-1181.
A population-based epidemiologic study of Helicobacter pylori infection and its association with systemic inflammation. Helicobacter 2009 Oct;14(5):108-113.
Pathogenic mechanisms of Helicobacter pylori. Gastroenterol Clin North Am 1993 Mar;22(1):43-57.
Association of neutrophil to lymphocyte ratio with presence and severity of gastritis due to Helicobacter pylori infection. J Clin Lab Anal 2014 May;28(3):219-223.
Total leukocyte counts and neutrophil- lymphocyte count ratios among Helicobacter pylori-infected patients with peptic ulcers: independent of bacterial CagA status. Southeast Asian J Trop Med Public Health 2013 Jan;44(1):82-88.