Role of Renin–Angiotensin-converting Enzyme Level
and ACE Gene Polymorphism in Patients with
Nonalcoholic Fatty Liver Disease
Demet D Tekatas, Ibrahim H Bahcecioglu, Murat Ispiroglu, Abdurrahman Sahin, Necip Ilhan, Mehmet Yalniz, Ulvi Demirel
Citation Information :
D Tekatas D, H Bahcecioglu I, Ispiroglu M, Sahin A, Ilhan N, Yalniz M, Demirel U. Role of Renin–Angiotensin-converting Enzyme Level and ACE Gene Polymorphism in Patients with Nonalcoholic Fatty Liver Disease. Euroasian J Hepatogastroenterol 2016; 6 (2):137-142.
Introduction: In this study, we aimed to investigate the histological and clinical effect of angiotensinconverting
enzyme (ACE) and ACE gene polymorphism in nonalcoholic fatty liver disease (NAFLD)
and their roles in the progression of the disease.
Materials and methods: Liver function tests, body mass index, waist circumference, lipid parameters,
fasting blood glucose (FBG), hemoglobin A1c (HbA1c), homeostasis model assessment-IR (HOMA-IR),
ACE, and ACE gene polymorphism were evaluated in the NAFLD group and control group. The study
group was evaluated by dividing the group into four subgroups by ACE gene polymorphism (D/D homozygous,
I/I homozygous, D/I heterozygous, I/D heterozygous). Liver biopsies were evaluated according
to Brunt Classification.
Results: A total of 31 patients who were diagnosed with NAFLD and 40 healthy individuals were
included in the study. The ACE level was found to be 11.69 ± 1.99 in the NAFLD group and 11.52 ± 1.72
in the control group (p = 0.70). There was a negative correlation between ACE levels and HOMA-IR
levels (p = 0.008, r= −0.512). Biochemical parameters were not different among ACE gene polimorphism
subgroups, except FBG (between D/D, I/D and D/I, I/D; p = 0.02). When the ACE levels were compared
in terms of grade and stage, no significant difference was found (for stage and grade p = 0.68). The ACE
gene polymorphism subgroups did not differ by histopathologic findings; grade and stage (for grade
p = 0.42, for stage p = 0.92).
Conclusion: In this study, we could not find a correlation of ACE and ACE gene polymorphism with
metabolic risk factors and the disease severity in NAFLD.