Euroasian Journal of Hepato-Gastroenterology

Register      Login

VOLUME 6 , ISSUE 1 ( January-June, 2016 ) > List of Articles

ORIGINAL ARTICLE

The Evaluation of Serum Ascites Albumin Gradient and Portal Hypertensive changes in Cirrhotic Patients with Ascites

Salimur Rahman, Mamun Al-Mahtab, Forhad Hossain Md Shahed

Citation Information : Rahman S, Al-Mahtab M, Hossain Md Shahed F. The Evaluation of Serum Ascites Albumin Gradient and Portal Hypertensive changes in Cirrhotic Patients with Ascites. Euroasian J Hepatogastroenterol 2016; 6 (1):8-9.

DOI: 10.5005/jp-journals-10018-1157

License: CC BY-NC 4.0

Published Online: 01-01-2016


Abstract

Introduction: Ascites is a common complication of chronic liver diseases and is related to the extent of portal hypertension. This study evaluated whether the serum ascites albumin gradient (SAAG) (the difference between the albumin level of serum and of ascitic fluid) is endowed with clinical implications. Materials and methods: This is a prospective study involving 50 patients with cirrhosis of liver with ascites. The SAAG was measured in all patients and its relation with portal hypertensive changes was analyzed. Results: Based on SAAG values, the patients were divided into three groups: Group 1 – SAAG value 1.1 to 1.49 gm/dL (n = 15); group 2 – SAAG value 1.5 to 1.99 gm/dL (n = 9); and group 3 – SAAG value 2.0 gm/dL (n = 26). In group 1, 14 patients had esophageal varices (93.3%) and 13 had gastropathy (86.6%). In group 2, all 9 patients had esophageal varices (100%), 7 (77.7%) had gastropathy, and 1 (11.1%) had gastric varices. In group 3, all 26 patients had esophageal varices (100%), 24 patients (92.3%) had gastropathy, and 1 patients (3.8%) had gastric varices. Conclusion: Serum ascites albumin gradient value is weakly related to the extent of portal hypertension in patients with liver cirrhosis and its implication seems to be limited in clinics.


PDF Share
  1. Al-Knawy B. Aetiology of ascites and diagnostic value of serum ascites albumin gradient in noalcoholic liver disease. Ann Saudi Med 1997 Jan;17(1):26-28
  2. Serum-ascites albumin gradient: a predictor of esophageal varices with ascites. Indian J Pediatr 2001 Jun;68(6):511-514
  3. Two findings of portal hypertension: evaluation of correlation between serum-ascites albumin gradient and esophageal varices in non-alcoholic cirrhosis. Turk J Gastroenterol 2003 Dec;14(4):219-222
  4. Serum-ascites albumin concentration gradient: a physiologic approach to the differential diagnosis of ascites. Gastroenterology 1983 Aug;85(2):240-244.
PDF Share

© Jaypee Brothers Medical Publishers (P) LTD.