Euroasian Journal of Hepato-Gastroenterology

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VOLUME 6 , ISSUE 1 ( January-June, 2016 ) > List of Articles

ORIGINAL ARTICLE

Lactose Intolerance and Symptom Pattern of Lactose Intolerance among Healthy Volunteers

Shasanka Kumar Saha, Bimal Chandra Shil, Madhusudan Saha, Irin Parveen

Citation Information : Kumar Saha S, Chandra Shil B, Saha M, Parveen I. Lactose Intolerance and Symptom Pattern of Lactose Intolerance among Healthy Volunteers. Euroasian J Hepatogastroenterol 2016; 6 (1):5-7.

DOI: 10.5005/jp-journals-10018-1156

License: CC BY-NC 4.0

Published Online: 00-00-0000


Abstract

Aims: To see the prevalence of lactose intolerance (LI) and related symptoms following oral lactose challenge in healthy volunteers. Materials and methods: Symptoms of abdominal pain, nausea, borborygmi, flatulence, and diarrhea were noted for 24 hours and blood glucose was estimated at 0 hour and 30 minutes after 25 gm oral lactose load to healthy volunteers. Failure to rise blood glucose level ≥ 1.1 mmol/l at 30 minutes after lactose intake from fasting level was taken as lactose malabsorption (LM), i.e., LI. Results: A total of 166 volunteers (123 males, 43 females) with a mean age 34.78 ± 11.45 years participated in this study. Lactose intolerance was found among 85.54% (n = 142, M = 104, F = 38). The main symptoms of LI were diarrhea (n = 83, 58.4.0%), borborygmi (n = 81, 57.04%), abdominal pain (n = 35, 24.65%), and flatulence (n = 27, 19.0%). Conclusion: Lactose intolerance among healthy adults may be common in Bangladesh. Diarrhea and borborygmi were mostly associated symptoms of LI.


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  1. Cox TM, Dissacharidase deficiency. In: Warrel DA, Cox TM, Firth JD, Benz EJ Jr, editors. Oxford Textbook of Medicine. 5th ed. Oxford University Press; 2003. p. 503-507
  2. Tribal incidence of lactase deficiency in Uganda. Lancet 1966 Apr 2;1(7440):725-729
  3. Lactase deficiency in Jewish communities in Israel. Am J Dig Dis 1970 Oct;15(10): 895-904
  4. Lactose intolerance in Asians. Nature 1967 Dec 23;216(5121):1244-1245
  5. Milk and lactose intolerance in healthy Orientals. Science 1968 Apr 5;160(3823):83-84
  6. Lactose malabsorption and diarrhea. Nutrition 1997 Jan;13(1):53-54
  7. Lactase deficiency and lactose malabsorption. A review. Z Gastroenterol 1986 Mar;24(3):125-134
  8. How much lactose is low lactose? J Am Diet Assoc 1996 Mar;96(2):243-246
  9. Lactose maldigestion in different age groups of north Indians. Trop Gastroenterol 2004 Jan-Mar;25(1):18-20
  10. Lactose malabsorption and its ethnic differences in Hans and Uyghurs. Chin Med J (Engl) 1988 Apr;101(4):284-286
  11. Assessment of symptom based criteria (Rome II) for the diagnosis of irritable bowel syndrome. Bangladesh J Med 2004;15(1):5-8
  12. Lactose malabsorption in Bangladeshi village children: relation with age, history of recent diarrhoea, nutritional status and breast feeding. Am J Clin Nutr 1979 Sep;32(9):1962-1969
  13. A comparison of diagnostic tests for lactose malabsorption – which one is the best? BMC Gastroenterology 2009 Oct 31;9:82
  14. Lactose intolerance in patients with irritable bowel syndrome from northern India: a case control study. J Gastroenterol Hepatol 2007 Dec;22(12):2261-2265
  15. Systemic lactose intolerance: a new perspective on an old problem. Postgrad Med J 2005 Mar;81(953):167-173
  16. The geographic hypothesis and lactose malabsorption. A weighing of the evidence Am J Dig Dis 1978 Nov;23(11): 963-980
  17. Frequency of lactose malabsorption among healthy southern and northern Indian population by genetic analysis and lactose hydrogen and tolerance test. Am J Clin Nutr 2010 Jan;91(1):140-146
  18. Lactose tolerance and intolerance in Malaysians. IeJSME 2012;6(Suppl 1):S12-S23.
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