Euroasian Journal of Hepato-Gastroenterology

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VOLUME 5 , ISSUE 2 ( July-December, 2015 ) > List of Articles

ORIGINAL ARTICLE

Drug-induced Liver Disease in Patients with Diabetes Mellitus

Klyarytskaya Iryna, Maksymova Helen, Stilidi Elena

Citation Information : Iryna K, Helen M, Elena S. Drug-induced Liver Disease in Patients with Diabetes Mellitus. Euroasian J Hepatogastroenterol 2015; 5 (2):83-86.

DOI: 10.5005/jp-journals-10018-1140

License: CC BY-NC 4.0

Published Online: 01-07-2015


Abstract

The study presented here was accomplished to assess the course of drug-induced liver diseases in patient’s rheumatoid arthritis receiving long-term methotrexate therapy. Diabetes mellitus was revealed as the most significant risk factor. The combination of diabetes mellitus with other risk factors (female sex) resulted in increased hepatic fibrosis, degree of hepatic encephalopathy and reduction of hepatic functions. The effectiveness and safety of ursodeoxycholic acid and cytolytic type-with S-Adenosyl methionine was also evaluated. Abbreviations: 13C-MBT: 13C-methacetin breath test; ALT: alanine aminotransferase; AP: alkaline phosphatase; AST: aspartic transaminase; DILD: drug-induced liver disease; DM: diabetes mellitus; HE: hepatic encephalopathy; HFM: hepatic functional mass; SAMe: S-Adenosyl methionine; UDCA: ursodeoxycholic acid.


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