Euroasian Journal of Hepato-Gastroenterology

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VOLUME 5 , ISSUE 2 ( July-December, 2015 ) > List of Articles

ORIGINAL ARTICLE

Expressions of TIMP-1, COX-2 and MMP-7 in Colon Polyp and Colon Cancer

Göksel Bengi, Didem Keles, Ömer Topalak, Mustafa Yalçin, Rabia Kiyak, Gülgün Oktay

Citation Information : Bengi G, Keles D, Topalak Ö, Yalçin M, Kiyak R, Oktay G. Expressions of TIMP-1, COX-2 and MMP-7 in Colon Polyp and Colon Cancer. Euroasian J Hepatogastroenterol 2015; 5 (2):74-79.

DOI: 10.5005/jp-journals-10018-1138

License: CC BY-NC 4.0

Published Online: 01-07-2015


Abstract

Objective: We aimed to investigate the relationship of expression of matrix metalloproteinase-7 (MMP-7), tissue inhibitor of metalloproteinase-1 (TIMP-1) and cyclooxygenase-2 (COX-2) in colon cancer and its predecessor colon polyp. Materials and methods: This study included 29 patients with colon polyp, 19 patients with colon cancer and 65 healthy control subjects. The expressions of MMP-7, TIMP-1 and COX-2 were investigated by real time-polymerase chain reaction (RT-PCR). Results: The expressions of TIMP-1, COX-2 and MMP-7 levels were significantly higher in polyp tissue compared to normal tissue (p = 0.024, p < 0.001, p = 0.009, respectively). Expression of TIMP-1, COX-2 and MMP-7 in cancer tissues were higher than both normal tissue and polyp tissue (p = 0.009 and p = 0.001; p < 0.001 and p < 0.001; p = 0.029 and p = 0.008, respectively). In the cancer group, no significant relationship was detected between metastasis and MMP-7, TIMP-1 and COX-2 expressions (p > 0.05). In the polyp tissues, no significant relationship was detected between the histologic type and size of polyps and MMP-7, TIMP-1 and COX-2 levels (p > 0.05). The areas under the receiver operating characteristic (ROC) curve for the cancer group were 0.821 for TIMP-1, 0.888 for COX-2, and 0.880 for MMP-7 (p = 0 < 0.001). Conclusion: A role and implication of expressions of MMP-7, COX-2 and TIMP-1 in colon cancer is predicted.


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