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VOLUME 5 , ISSUE 2 ( July-December, 2015 ) > List of Articles

ORIGINAL ARTICLE

Expressions of TIMP-1, COX-2 and MMP-7 in Colon Polyp and Colon Cancer

Göksel Bengi, Didem Keles, Ömer Topalak, Mustafa Yalçin, Rabia Kiyak, Gülgün Oktay

Citation Information : Bengi G, Keles D, Topalak Ö, Yalçin M, Kiyak R, Oktay G. Expressions of TIMP-1, COX-2 and MMP-7 in Colon Polyp and Colon Cancer. Euroasian J Hepatogastroenterol 2015; 5 (2):74-79.

DOI: 10.5005/jp-journals-10018-1138

License: CC BY-NC 4.0

Published Online: 01-06-2017

Copyright Statement:  Copyright © 2015; The Author(s).


Abstract

Objective: We aimed to investigate the relationship of expression of matrix metalloproteinase-7 (MMP-7), tissue inhibitor of metalloproteinase-1 (TIMP-1) and cyclooxygenase-2 (COX-2) in colon cancer and its predecessor colon polyp. Materials and methods: This study included 29 patients with colon polyp, 19 patients with colon cancer and 65 healthy control subjects. The expressions of MMP-7, TIMP-1 and COX-2 were investigated by real time-polymerase chain reaction (RT-PCR). Results: The expressions of TIMP-1, COX-2 and MMP-7 levels were significantly higher in polyp tissue compared to normal tissue (p = 0.024, p < 0.001, p = 0.009, respectively). Expression of TIMP-1, COX-2 and MMP-7 in cancer tissues were higher than both normal tissue and polyp tissue (p = 0.009 and p = 0.001; p < 0.001 and p < 0.001; p = 0.029 and p = 0.008, respectively). In the cancer group, no significant relationship was detected between metastasis and MMP-7, TIMP-1 and COX-2 expressions (p > 0.05). In the polyp tissues, no significant relationship was detected between the histologic type and size of polyps and MMP-7, TIMP-1 and COX-2 levels (p > 0.05). The areas under the receiver operating characteristic (ROC) curve for the cancer group were 0.821 for TIMP-1, 0.888 for COX-2, and 0.880 for MMP-7 (p = 0 < 0.001). Conclusion: A role and implication of expressions of MMP-7, COX-2 and TIMP-1 in colon cancer is predicted.

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  1. Asano T, Tada M, Cheng S, Takemoto N, Kuramae T, Abe M, Takahashi O, Miyamoto M, Hamada J, Moriuchi T, et al. Prognostic values of matrix metalloproteinase family expression in human colorectal carcinoma. J Surg Res 2008; 146(1):32-42
  2. Expression and activity levels of matrix metalloproteinase- 7 and in situ localization of caseinolytic activity in colorectal cancer. Clin Biochem 2014;47(13-14):1265-1271
  3. Immuno-histochemical expression of MMP-7 protein and its serum level in colorectal cancer. Folia Histochem Cytobiol 2013;51(3):306-312
  4. Modulation of matrilysin levels in colon carcinoma cell lines affects tumorigenicity in vivo. Cancer Res 1994;54(17):4805-4812
  5. Beta-catenin regulates the expression of the matrix metalloproteinase-7 in human colorectal cancer. Am J Pathol 1999;155(4):1033-1038
  6. Interplay of insulin-like growth factor-II, insulin-like growth factor-I, insulin-like growth factor-I receptor, COX-2 and matrix metalloproteinase-7, play key roles in the early stage of colorectal carcinogenesis. Clin Cancer Res 2004;10(23): 7950-7957
  7. Enhanced expression of tissue inhibitors of metalloproteinases in human colorectal tumors. Jpn J Clin Oncol 1996;26(5):303-309
  8. The behaviour of matrix metalloproteinases and their inhibitors in colorectal cancer. Int J Mol Sci 2012;13(10):13240-13263
  9. Role of cyclooxygenase-2 in the carcinogenesis of gastrointestinal Expressions of TIMP-1, COX-2 and MMP-7 in Colon Polyp and Colon Cancer Euroasian Journal of Hepato-Gastroenterology, July-December 2015;5(2):74-79 79 EJOHG tract cancers: a review and report of personal experience. World J Gastroenterol 2006;12(9):1336-1345
  10. Clinicopathologic and prognostic significance of matrilysin expression at the invasive front in human colorectal cancers. Int J Cancer 2001;95(5):290-294
  11. Clinicopathological asssesment and quantitative estimation of the matrix metalloproteinases MMP-2 and MMP-7 and the inhibitors TIMP-1 and TIMP-2 in colorectal carcinoma tissue samples. Anticancer Res 2007;27(4A):1863-1867
  12. Simultaneous determination of matrix metalloproteinase (MMP)-7, MMP-1, -3 and -13 gene expression by multiplex PCR in colorectal carcinomas. Int J Colorectal Dis 2004;19(6):518-524
  13. Clinicopathologic and prognostic significance of MMP-7 (matrilysin) expression in human rectal cancer. JPN J Clin Oncol 2005;35(12):739-744
  14. Clinicopathologic and prognostic significance of matrix metalloproteinases in rectal cancer. Int J Clin Oncol 2007;22(2):127-136
  15. Expression and clinical significance of matrilysin (MMP-7) in human rectal cancer. Sichuan Da Xue Xue Bao Yi Xue Ban 2007;38(4): 637-640
  16. Correlation between the immunhistochemical expressions of MMP-1, MMP-7 and VEGF and prognostic factors in colorectal adenocarcinoma. Acta Cir Bras 2009; 24(4):303-310
  17. Serum matrix metalloproteinase-7 levels identifies poor prognosis advanced colorectal cancer patients. Int J Cancer 2007;121(5):1066-1071
  18. Matrix metalloproteinase-7 increases resistance to Fas-mediated apoptosis and is a poor prognostic factor of patients with colorectal carcinoma. Carcinogenesis 2006;27(5):1113-1120
  19. Matrix metalloproteinases and tissue inhibitors of metalloproteinases in colonic adenomasadenocarcinomas. Dis Colon Rectum 1996;39(11):1255-1264
  20. The diagnostic value of matrix metalloproteinase-9 (MMP-9) and tissue inhibitor of matrix metalloproteinases-1 (TIMP-1) determination in the sera of colorectal adenoma and cancer patients. Int J Colorectal Dis 2010;25(10):1177-1184
  21. Evaluation of predictive markers for patients with advanced colorectal cancer. Acta Oncol 2012;51(7):849-859
  22. Plasma levels of matrix metalloproteinase-2 and tissue inhibitor of metalloproteinase-1 correlate with disease stage and survival in colorectal cancer patients. Dis Colon Rectum 2005;48(4): 700-710
  23. Up-regulation of cyclooxygenase-2 gene expression in human colorectal adenomas and adenocarcinomas. Gastroenterol 1994;107(4):1183-1188
  24. Association of Ets-related transcriptional factor E1AF expression with overexpression of matrix metalloproteinases, COX-2 and iNOS in the early stage of colorectal carcinogenesis. Carcinogenesis 2005;26(5):892-899
  25. Colorectal adenoma to carcinoma progression is accompanied by changes in gene expression associated with ageing, chromosomal instability and fatty acid metabolism. Cell Oncol 2012;35(1): 53-63
  26. Aspirin and the risk of colorectal cancer in relation to the expression of COX-2. N Engl J Med 2007;356(21):2131-2142.
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