Euroasian Journal of Hepato-Gastroenterology

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VOLUME 5 , ISSUE 1 ( January-June, 2015 ) > List of Articles

ORIGINAL ARTICLE

Nonalcoholic Fatty Liver Disease: Study of Demographic and Predictive Factors

Madhusudan Saha, Bimal Chandra Shil, Faruque Ahmed, Swapan Chandra Dhar

Citation Information : Saha M, Chandra Shil B, Ahmed F, Chandra Dhar S. Nonalcoholic Fatty Liver Disease: Study of Demographic and Predictive Factors. Euroasian J Hepatogastroenterol 2015; 5 (1):4-6.

DOI: 10.5005/jp-journals-10018-1119

License: CC BY-NC 4.0

Published Online: 01-01-2015


Abstract

Background: Nonalcoholic fatty liver disease (NAFLD) represents a spectrum of liver disease characterized by excess of fat in liver which ranges from simple steatosis to nonalcoholic steatohepatitis (NASH), cirrhosis and hepatocellular carcinoma (HCC) in the absence of excessive alcohol consumption. Materials and methods: The study was carried out in 216 with sonologically defined fatty liver. They underwent detailed history evaluation, clinical examination and anthropometric measurements, biochemical and serological tests. The cut-off values for central obesity were waist hip ratio (WHR) > 0.85 in women and > 0.9 in men. Results: The prevalence of NAFLD was highest in the age group of 31 to 60 years. It was more common in males than females. Twenty cases (11.7%) had discomfort at right upper abdomen. Hepatomegaly was found in 27 patients (13.2%), impaired glucose tolerance (IGT) in 29 (14.21%) and diabetes mellitus in 38 (18.63%) patients. Overweight or obesity was found in 110 (53.92%) cases and central obesity was seen in 129 (63.23%) patients. Hence, metabolic syndrome (according to International Diabetes Federation Criteria) was present in 62.25% cases of NAFLD. Alanine aminotransferase (ALT) more than upper limit of normal was found in 36.76% cases. Conclusion: Risk factors for NAFLD in Bangladesh are similar to reported from the rest of the world. Age more than 30 years, male sex, WHR > 0.9 in men and more than 0.85 in female, BMI more than 25, glucose intolerance are predictive factors for NAFLD.


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  1. Sanyal AJ. American Gastroenterological Association AGA technical review on nonalcoholic fatty liver disease. Gastroenterol 2002;123(5):1705-1725
  2. The diagnosis and management of nonalcoholic fatty liver disease: practice guideline by the American Association for the study of liver diseases, American College of Gastroenterology and the American Gastroenterological Association. Hepatol 2012;55(6):2005-2023
  3. Review article: current management of nonalcoholic fatty liver disease and nonalcoholic steatohepatitis. Aliment Phamacol Ther 2008;28(1):2-12
  4. Chitturi S, Lau GKK, Sollano I. Guidelines for the assessment and management of nonalcoholic fatty liver disease in the Asia Pacific region. Executive summary. J Gastroenterol Hepatol 2007;22(6):775-777
  5. How common is nonalcoholic fatty liver disease in Asia Pacific region and there local differences? J Gastroenterol Hepatol 2007;22(6):788-793
  6. Association between nonalcoholic fatty liver disease and metabolic syndrome. Int J Hepatol 2010;1(4):17-24
  7. Prevalence of nonalcoholic fatty liver disease: population based study. Ann Hepatol 2007;6(3):161-163
  8. Editors choice, nonalcoholic fatty liver disease in India. BMJ 2011;343(7816):d4652
  9. Nonalcoholic fatty liver disease in India—a lot done, yet more required! Indian J Gastroenterol 2010 Nov;29:217-225
  10. Obesity, visceral fat and NAFLD: Querying the role of adipokines in the progression of nonalcoholic fatty liver disease. ISRN Gastroenterol 2011 Aug 28;2011:592404:1-19
  11. Prevalence of nonalcoholic fatty liver disease in patients with type 2 diabetes mellitus. J Assoc Physicians India 2009 Mar;57:205-210
  12. Nonalcoholic fatty liver disease may not be a severe disease at presentation among Indians. World J Gastroenterol 2006;12(21):3400-3405
  13. Relationship of nonalcoholic fatty liver disease with cholecystectomy in US population. Am J Gastroenterol 2013;108(6):952-958.
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