Citation Information :
Rauf Maksud A, Andrey Gennadiyevich P, Rasim Elkhan J. Influence of Mesenchymal Stem Cells Transplantation on Regeneration Activity of Cirrhotic Liver. Euroasian J Hepatogastroenterol 2014; 4 (2):83-86.
The efficacy of mesenchymal stem cells transplantation on regeneration activity of cirrhotic liver
was evaluated in an animal model of cirrhotic liver. Autologous stem cells were obtained from bone
marrow. Transplantation was performed 1 week after surgery by introducing stem cells into the
liver. Immunohistochemical staining (proliferative activity, myofibroblast activation and sinusoidal
capillarization) was evaluated to assess the efficacy of transplantation. It was found that, 2 months
after stem cell transplantation, the severity of perisinusoidal fibrosis, inflammation of the liver and the
number of myofibroblasts were reduced. Stem cell transplantation may be one of the new treatment
modalities for cirrhotic liver.
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