Euroasian Journal of Hepato-Gastroenterology

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VOLUME 4 , ISSUE 2 ( July-December, 2014 ) > List of Articles

ORIGINAL ARTICLE

Influence of Mesenchymal Stem Cells Transplantation on Regeneration Activity of Cirrhotic Liver

Agayev Rauf Maksud, Popandopulo Andrey Gennadiyevich, Jafarli Rasim Elkhan

Citation Information : Rauf Maksud A, Andrey Gennadiyevich P, Rasim Elkhan J. Influence of Mesenchymal Stem Cells Transplantation on Regeneration Activity of Cirrhotic Liver. Euroasian J Hepatogastroenterol 2014; 4 (2):83-86.

DOI: 10.5005/jp-journals-10018-1107

License: CC BY-NC 4.0

Published Online: 01-07-2014


Abstract

The efficacy of mesenchymal stem cells transplantation on regeneration activity of cirrhotic liver was evaluated in an animal model of cirrhotic liver. Autologous stem cells were obtained from bone marrow. Transplantation was performed 1 week after surgery by introducing stem cells into the liver. Immunohistochemical staining (proliferative activity, myofibroblast activation and sinusoidal capillarization) was evaluated to assess the efficacy of transplantation. It was found that, 2 months after stem cell transplantation, the severity of perisinusoidal fibrosis, inflammation of the liver and the number of myofibroblasts were reduced. Stem cell transplantation may be one of the new treatment modalities for cirrhotic liver.


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  2. Mechanisms of fibrogenesis in liver cirrhosis: the molecular aspects of epithelial-mesenchymal transition. World J Hepatol 2014 Apr 27;6(4):207-216
  3. Complications of portal hypertension in adults: a French consensus. Eur J Gastroenterol Hepatol 2005 Apr;17(4):403-410
  4. Hepatocyte growth factor gene transfer into the liver via the portal vein using electroporation attenuates rat liver cirrhosis. Gene Ther 2003 Sep;10(18):1559-1566
  5. Mesenchymal stem cellderived molecules reverse fulminant hepatic failure. PLoS One 2007 Sep;2(9):e941
  6. Improved liver function in patients with liver cirrhosis after Figs 3A and B: Myofibroblast activation: (A) Before transplantation (intense), (B) 2 months after transplantation (sporadic cells). Staining with a-SMA antibodies (immunohistochemical reaction product in red color) (magnification: 400×) autologous bone marrow cell infusion therapy. Stem Cells 2006 Oct;24(10):2292-2298
  7. The osteogenic differentiation stimulating activity of Sea cucumber methanolic crude extraction on rat bone marrow mesenchymal stem cells. Iran J Basic Med Sci 2014 Aug;17(8): 626-631
  8. Concise review: mesenchymal stem/multipotent stromal cells: the state of transdifferentiation and modes of tissue repair-current views. Stem Cells 2007 Nov;25(11):2896-2902
  9. Biological characteristics of human bone marrow mesenchymal stem cell cultured in vitro. J Huazhong Univ Sci Technolog Med Sci 2005;25(3):307-309
  10. In vitro hepatic differentiation of human mesenchymal stem cells. Hepatology 2004 Dec;40(6):1275-1284
  11. Formulation and application of a numerical scoring system for assessing histological activity in asymptomatic chronic active hepatitis. Hepatology 1981;1(5):431-435.
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