Citation Information :
Rauf Maksud A, Andrey Gennadiyevich P, Rasim Elkhan J. Influence of Mesenchymal Stem Cells Transplantation on Regeneration Activity of Cirrhotic Liver. Euroasian J Hepatogastroenterol 2014; 4 (2):83-86.
The efficacy of mesenchymal stem cells transplantation on regeneration activity of cirrhotic liver
was evaluated in an animal model of cirrhotic liver. Autologous stem cells were obtained from bone
marrow. Transplantation was performed 1 week after surgery by introducing stem cells into the
liver. Immunohistochemical staining (proliferative activity, myofibroblast activation and sinusoidal
capillarization) was evaluated to assess the efficacy of transplantation. It was found that, 2 months
after stem cell transplantation, the severity of perisinusoidal fibrosis, inflammation of the liver and the
number of myofibroblasts were reduced. Stem cell transplantation may be one of the new treatment
modalities for cirrhotic liver.
Improved liver function in patients with liver cirrhosis after Figs 3A and B: Myofibroblast activation: (A) Before transplantation (intense), (B) 2 months after transplantation (sporadic cells). Staining with a-SMA antibodies (immunohistochemical reaction product in red color) (magnification: 400×) autologous bone marrow cell infusion therapy. Stem Cells 2006 Oct;24(10):2292-2298
The osteogenic differentiation stimulating activity of Sea cucumber methanolic crude extraction on rat bone marrow mesenchymal stem cells. Iran J Basic Med Sci 2014 Aug;17(8): 626-631
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Biological characteristics of human bone marrow mesenchymal stem cell cultured in vitro. J Huazhong Univ Sci Technolog Med Sci 2005;25(3):307-309
In vitro hepatic differentiation of human mesenchymal stem cells. Hepatology 2004 Dec;40(6):1275-1284
Formulation and application of a numerical scoring system for assessing histological activity in asymptomatic chronic active hepatitis. Hepatology 1981;1(5):431-435.