Euroasian journal of hepato-gastroenterology

Register      Login

VOLUME 4 , ISSUE 2 ( July-December, 2014 ) > List of Articles

ORIGINAL ARTICLE

Platelet Number and Indexes during Acute Pancreatitis

Bora Aktas, Metin Küçükazman, Ayse Kefeli, Sebahat Basyigit, Abdullah Özgür Yeniova, Yasar Nazligül

Citation Information : Aktas B, Küçükazman M, Kefeli A, Basyigit S, Özgür Yeniova A, Nazligül Y. Platelet Number and Indexes during Acute Pancreatitis. Euroasian J Hepatogastroenterol 2014; 4 (2):67-69.

DOI: 10.5005/jp-journals-10018-1104

License: CC BY-NC 4.0

Published Online: 01-07-2013

Copyright Statement:  Copyright © 2014; The Author(s).


Abstract

Aim: Acute pancreatitis (AP) is an inflammatory disorder, the incidence of which has been increasing over recent years. Mean platelet volume (MPV) is an index of platelet activation and influenced by inflammation. The objective of the present study is to assess whether MPV would be convenient parameters for predictor factor of patients with AP. Materials and methods: A total of 140 AP patients (male/female: 63/77) and 70 healthy subjects (male/female: 23/47) were enrolled in this study. The following data were extracted from the hospital medical records, including age, sex, platelet count, MPV, were recorded at the time of admission and as well as at the 1st day of remission of the disease. Results: Mean platelet volume levels at onset and remission of AP were 7.8 ± 1.6 and 7.7 ± 0.9 respectively, and there was no statistically significant difference between these groups. Platelet count at onset and remission of AP and control subjects was 203 ± 74 × 103/μl, 234 ± 76 × 103/μl and 251 ± 87 × 103/μl, respectively, and there was statistically significant difference between these groups. Platelet count at onset and remission of AP was statistically lower than control subjects. Conclusion: Some studies in literature suggest that MPV might be a useful parameter to be used as an indicator for AP and a prognostic factor for AP, but, in this study, it was revealed that MPV values do not change at AP compared with controls. Therefore, further prospective studies investigating the factors affecting the platelet size are required to determine whether MPV has a clinical implication and for predictor value of patients with AP.


PDF Share
  1. Imrie CW. Acute pancreatitis: an overview. Eur J Gastroenterol Hepatol 1997 Feb;9(2):103-105
  2. Pathophysiolgy of acute pancreatitis. Pancreatology 2005;5(2-3):132-144
  3. Inflammatory mediators in acute pancreatitis. J Pathol 2000 Feb;190(2):117-125
  4. Consumptive coagulopathy, fibrinolysis and protease-antiprotease interactions during acute human pancreatitis. Thromb Res 1986 Jan;4l(2):167-183
  5. Platelet count as a sensitive and convenient parameter for assessing the prognosis in acute pancreatitis. Pancreas 2008 Aug; 37(2):225-227
  6. Multiple organ dysfunction associated with severe acute pancreatitis. Crit Care Med 2002;30:1274-1279
  7. Early changes in organ function predict eventual survival in severe sepsis. Crit Care Med 2005 Oct;33(10):2194-2201
  8. Mean platelet volume in patients with acute pancreatitis. J Clin Exp Invest 2011;2(4): 362-365
  9. mean platelet volume as an indicator of disease severity in patients with acute pancreatitis. Clin Res Hepatol Gastroenterol 2012;36(2): 162-168
  10. Alterations of platelet function, number and indexes during acute pancreatitis. Pancreatology 2004;4(1):22-27
  11. Assessment of platelet adhesiveness and aggregation in mild acute pancreatitis using the PFA-100 system. JOP 2004 May;5(3):132-137
  12. Platelet-activating factor and platelet-activating factor antagonists in acute pancreatitis. Dig Surg 1999;16(2): 93-101
  13. Alterations of platelet function and coagulation parameters during acute pancreatitis. Blood Coagul Fibrinolysis 2013 Apr;24(3):243-246.
PDF Share
PDF Share

© Jaypee Brothers Medical Publishers (P) LTD.