Euroasian journal of hepato-gastroenterology

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VOLUME 4 , ISSUE 1 ( January-June, 2014 ) > List of Articles


Feasibility of Concurrent Chemoradiation in Patients treated for Esophageal Carcinoma: A Single Institutional Experience

Ram Abhinav Kannan

Citation Information : Abhinav Kannan R. Feasibility of Concurrent Chemoradiation in Patients treated for Esophageal Carcinoma: A Single Institutional Experience. Euroasian J Hepatogastroenterol 2014; 4 (1):11-13.

DOI: 10.5005/jp-journals-10018-1089

License: CC BY-NC 4.0

Published Online: 01-04-2018

Copyright Statement:  Copyright © 2014; The Author(s).


Background: Chemoradiation has shown superior overall survival when compared with radiation alone in esophageal carcinoma. Due to compromised nutritional status, radiation therapy in esophageal cancer patients itself is a challenge and addition of concurrent chemotherapy leads to severe side effects even when standard dose regimens are used. The tolerance of chemoradiation for carcinoma esophagus in Indian patients is still unclear. This study is an effort to know feasibility of chemoradiation in patients treated for esophageal carcinoma in our hospital. Materials and methods: A total of 47 consecutive patients of histologically proven esophageal carcinoma who were treated in MS Ramaiah Hospital were reviewed retrospectively from January to August 2013. Out of 47 patients, 20 patients were treated with concurrent chemoradiotherapy. Patients were assessed for number of days of treatment interruptions in radiation schedule and number of planned vs executed cycles of chemotherapy. Results: Out of the 20 patients treated with concurrent chemoradiotherapy, 13 patients were male (65%) and 7 (35%) were female. Median age of patients was 60 years (25-75 years). Squamous cell carcinoma was noted in majority of cases (19/20 cases). A total of 18 of 20 patients completed the planned dose of radiation and only 3/20 patients completed all planned cycles of chemotherapy. Mean number of days of interruption in radiation schedule in patients receiving chemoradiotherapy was 4.4 days. Conclusion: There was poor tolerance to chemoradiotherapy leading to reduction in the number of executed chemotherapy cycles as opposed to planned cycles, although there were no significant interruptions in radiation treatment.

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  1. Consolidated report of population based cancer registries 2001- 2004: National Cancer Registry Programme (ICMR); 2006. Available from: Bangalore
  2. Combined chemotherapy and radiotherapy compared with radiotherapy alone in patients with cancer of the esophagus. N Engl J Med 1992 Jun 11;326(24):1593-1598
  3. Progress report of combined chemoradiotherapy versus radiotherapy alone in patients with esophageal cancer: an intergroup study. J Clin Oncol 1997 Jan;15(1):277-284
  4. Combined chemoradiotherapy vs. radiotherapy alone for early stage squamous cell carcinoma of the esophagus: a study of the Eastern Cooperative Oncology Group. Int J Radiat Oncol Biol Phys 1998 Sep 1;42(2):269-276
  5. Esophageal cancers treated with radiotherapy: impact of total treatment time and fractionation. Int J Radiat Oncol Biol Phys 1994 Dec 1;30(5):1099-1105.
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