Greedy colon which is a synonym of constipation is a serious condition in the human body which may
lead to complications, like damage of the rectal tissue, cellular dehydration and colorectal cancer.
Diabetes mellitus, although a systemic disease with diverse clinical symptoms, is also related with
cellular dehydration. Understanding the pathophysiological aspects of diabetes mellitus and greedy
colon may shed light in the management of either of these conditions. The main purpose of this article
is to demonstrate an association of tissue dehydration during diabetes mellitus and constipation.
The adverse side effects of atropine will be discussed due to its M3 blockage effect and reduction in
peristalsis keeping in mind the importance of these facts in the context of public health importance,
especially in geriatric health.
Shoback D, Gardner DG. Greenspan’s basic and clinical endocrinology. Chapter 17. 9th ed. New York: McGraw-Hill Medical Publishing 2011:212
Protective effects of Annona muricata linn (Annonaceae) leaf aqueous extract on serum lipid profiles and oxidative stress in hepatocytes of Streptozotocin-treated diabetic rats. Afr J Trad Cam 2009;6(1):30-41
Antidiabetic and in vitro antioxidant potential of Hybanthus enneaspermus (Linn) F. Muell in streptozotocin-induced diabetic rats. Asian Pac J Trop Biomed 2011;1(4):316-322
Emerging risk factors collaboration. Diabetes mellitus, fasting blood glucose concentration and risk of vascular disease: a collaborative meta-analysis of 102 prospective studies. Lancet 2010;375:2215-2222
Effect of intensive glucose lowering treatment on all cause mortality, cardiovascular death and microvascular events in type 2 diabetes: meta-analysis of randomised controlled trials. BMJ 2011;343:4169
Form of the stool in constipation patient. Auto intoxication or intestinal toxemia. Michgan. Modern Medicine Publishing Company of Battle Creek 1919;1:113-116
Management of patients with stercoral perforation of the sigmoid colon: report of five cases. World J Gastroenterol 2006;12:500-503
Type 1 diabetes mellitus in pediatrics. Pediatr Rev 2008;29(11):374-384
Overview of neurogastroenterologygastrointestinal motility and functional GI disorders: classification, prevalence and epidemiology. Gastroenterol Clin North Am 2007;36(3):485
The treatment of chronic constipation in elderly people: an update. Drugs Aging 2004;21(11):911-930
Disorders of gastrointestinal motility. Chap 138. Cecil Medicine. 24th ed. Philadelphia, Pa: Saunders Elsevier, 2011:2223-2226
Constipation. Chap 18. Sleisenger and Fordtran’s Gastrointestinal and Liver Disease. 9th ed. Philadelphia, Pa: Saunders Elsevier 2010;1233-1234
Atropine inhibits the increase in gastric emptying during hypoglycemia in humans. Diabetes Care 1995;18:1463-1467
Different effects of atropine and cimetropium on gastric emptying of liquids and antroduodenal motor activity in man. Hepatogastroenterology 1990;37:242-246.