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VOLUME 3 , ISSUE 2 ( July-December, 2013 ) > List of Articles
Citation Information : Serum Proinflammatory Cytokines and its Relationship to 13C-Methacetin Breath Test Results in Patients with Chronic Hepatitis. Euroasian J Hepatogastroenterol 2013; 3 (2):120-123.
License: CC BY-NC 4.0
Published Online: 01-07-2013
Background: Further development and implementation of
methods for early noninvasive diagnosis for prognosis and
treatment efficiency in patients with chronic hepatitis and
development of effective methods of conservative therapy is
an important problem of modern hepatology.
Objective: To identify the correlation of proinflammatory
cytokines [tumor necrosis factor alpha (TNF- ) and interleukin-6
(IL-6)] with the results of 13C-methacetin breath test (13C-MBT)
(CVH), nonalcoholic steatohepatitis (NASH) and alcoholic
Materials and methods: A total of 147 patients with chronic
hepatitis and 25 healthy controls were studied. Patients were
divided into three groups: I (group CVH): 50 patients with CVH B
and C; II (group NASH): 49 patients with NASH; III (group AH):
48 patients with AH. TNF- and IL-6 was determined by ELISA.
Liver biopsy was performed in 46 patients,13C-MBT in 57 patients.
A total of 96 patients with F2-F4 Metavir were selected to study
patients with NASH, 30 patients with AH. Patients were divided
standard treatment (depending on the etiology of disease). The
second subgroup included 57 patients who received standard
daily. Controlled treatment period was 24 weeks.
Results and discussion: Found an inverse correlation between
the cumulative dose of 13CO2 and serum levels of TNF- in
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