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VOLUME 3 , ISSUE 2 ( July-December, 2013 ) > List of Articles
Citation Information : Serum Proinflammatory Cytokines and its Relationship to 13C-Methacetin Breath Test Results in Patients with Chronic Hepatitis. Euroasian J Hepatogastroenterol 2013; 3 (2):120-123.
License: CC BY-NC 4.0
Published Online: 01-12-2017
Copyright Statement: Copyright © 2013; The Author(s).
Background: Further development and implementation of methods for early noninvasive diagnosis for prognosis and treatment efficiency in patients with chronic hepatitis and development of effective methods of conservative therapy is an important problem of modern hepatology.
Objective: To identify the correlation of proinflammatory cytokines [tumor necrosis factor alpha (TNF- ) and interleukin-6 (IL-6)] with the results of 13C-methacetin breath test (13C-MBT) (CVH), nonalcoholic steatohepatitis (NASH) and alcoholic hepatitis (AH).
Materials and methods: A total of 147 patients with chronic hepatitis and 25 healthy controls were studied. Patients were divided into three groups: I (group CVH): 50 patients with CVH B and C; II (group NASH): 49 patients with NASH; III (group AH): 48 patients with AH. TNF- and IL-6 was determined by ELISA.
Liver biopsy was performed in 46 patients,13C-MBT in 57 patients.