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VOLUME 3 , ISSUE 2 ( July-December, 2013 ) > List of Articles
Nasim Abedi Manesh, Alireza Ostadrahimi, Saeed Abedymanesh, Mohammad Asghari Jafarabadi, Mohammad Hossein Somi, Ali Akbar Movassaghpour, Beitullah Alipour
Citation Information : Abedi Manesh N, Ostadrahimi A, Abedymanesh S, Asghari Jafarabadi M, Hossein Somi M, Akbar Movassaghpour A, Alipour B. Added Predictive Ability of Mean Platelet Volume and Red Disease Activity of Ulcerative Colitis. Euroasian J Hepatogastroenterol 2013; 3 (2):103-107.
License: CC BY-NC 4.0
Published Online: 01-12-2017
Copyright Statement: Copyright © 2013; The Author(s).
Background: Recently some noninvasive tests have been studied for determining the activity of disease in ulcerative colitis.
Aim: The aim of this study is to determine the added predictive ability of mean platelet volume (MPV) and red cell distribution activity of ulcerative colitis patients.
Materials and methods: Sixty-eight patients with ulcerative colitis were enrolled in this cross-sectional study. For all subjects white blood cell (WBC) count, platelet (PLT) count, RDW and MPV tests were performed. Serum high sensitivity C-reactive protein (hs-CRP) and proinflammatory cytokine; interleukin-12 (IL-12) levels were also measured. Disease activity was determined by endoscopic and clinical activity index (Powell-Tuck).
Results: There was an inverse significant association between MPV and clinical and endoscopic activity scores (p < 0.01). The levels of hs-CRP well correlated with disease activity (p = 0.01) while serum levels of IL-12 demonstrated no correlation with disease activity. Group markers including RDW, MPV, PLT counts added the predictive ability of disease activity about 20.6%. From these markers, RDW considered as an independent predictor of disease activity.
Conclusion: Our results suggest that easily available and inexpensive ability of inflammatory markers such as RDW, MPV and PLT may improve the predictive ability of inflammatory markers in disease activity of patients with ulcerative colitis.