Background: Cirrhotic cardiomyopathy is reported to be a major
cause of mortality and morbidity in liver transplant recipient. It
might be an emerging issue as liver transplantation has been
started in Bangladesh.
Materials and methods: Forty-four cirrhotic patients of varying
etiology and 44 healthy volunteers were enrolled as cases and
controls, respectively. Hepatic functional status was assessed
by clinical examination and biochemical tests. Transthoracic
echocardiography was done in both the groups.
Results: Deceleration time of cirrhotic patients was significantly
prolonged irrespective of etiology in comparison to controls
indicating diastolic dysfunction. Left ventricular systolic diameter
was also larger (significant statistically) in cirrhotic patients. Other
echocardiographic parameters like E/A ratio, EF, left ventricle
(LV) wall thickness, interventricular septal thickness and LV
diastolic diameter showed no significant difference. Cardiac
dysfunction does not depend on severity of hepatic dysfunction.
Conclusion: Cirrhotic patients irrespective of cause show
diastolic dysfunction. Cardiac dysfunction did not correlate the
severity of hepatic dysfunction.
Kowalski HJ, Abelmann WH. The cardiac output at rest in laennce’s cirrhosis. J Clin Invest 1953;32:1025-33
Prognostic value of arterial pressure, endogenous vasoactive systems and renal function in cirrhotic patients admitted to the hospital for treatment of ascites. Gastroenterology 1988;94:482-87
Noninvasive 24 hours ambulatory arterial blood pressure monitoring in cirrhosis. Hepatology 1995;22:88-95. Cirrhotic Cardiomyopathy in Bangladeshi Patients: A Pilot Study Euroasian Journal of Hepato-Gastroenterology, January-June 2013;3(1):42-45 45 EJOHG 4. Mollers S, Henriksen JH. Circulatory abnormalities in cirrhosis with focus on neurohumoral aspects. Semin Nephrol 1997;17: 505-19
Cirrhotic cardiomyopathy (abstract). Digestive and Liver Disease 2001;39:50-51
Cirrhotic cardiomyopathy: Indian scenario. J Gastroenterol Hepatol 2007;22:395-99
Portal hypertension. In: Thomson ABR, Shaffer EA (Eds). First principles of gastroenterology–the basis of disease and approach to management (5th ed). Edmonton, Alberta: Canadian Association of Gastroenterology; Accessed 1 Nov 2005
Cirrhotic cardiomyopathy: A pathophysiological review of circulatory dysfunction in liver disease. Heart 2002;87:9-15
Doppler echocardiography for the assessment of left ventricular diastolic function: Methodology, clinical and prognostic value. Ital Heart J Suppl 2004;5:86-97
Modification of cardiac function in cirrhotic patients with or without ascites. Am J Gastroenterol 2000;95:3200-05
Cardiac abnormalities in cirrhosis. Am J Gastroenterol 2001;96: 2503-05
Left ventricular volumes in liver cirrhosis. Dig Liver Dis 2000;32:392-97
Evidence of functional and structural cardiac abnormalities in cirrhotic patients with and without ascites. Hepatology 1997;26:1131-37