Objective: This retrospective study was planned to evaluate
role of fine needle aspiration cytology (FNAC) in space
occupying lesions of liver as first line investigation to differentiate
benign from malignant pathologies, primary vs secondary
malignancies and establishing exact diagnosis.
Materials and methods: A total number of 81 ultrasonography
(USG)-guided FNA liver were performed in Postgraduate
Institute of Medical Sciences (PGIMS), Rohtak from June 2010
to May 2011. Wet fixed and air dried smears were stained with
Papanicolaou and May-Grunwald-Giemsa respectively.
Results: Age ranged from 19 to 86 years. Sixty-seven out of
81 cases were conclusive. Four out of 67 were benign. Out of
remaining 63 malignant, six were primary lesions including four
cases of hepatocellular carcinoma, one of Burkitt’s lymphoma
and one of cholangiocarcinoma. Secondary metastatic lesions
were 44 including metastasis from malignant melanoma,
squamous cell carcinoma and leiomyosarcoma.
Conclusion: USG-guided FNAC is very useful tool in
establishing diagnosis of hepatic lesions as the procedure is
simple, safe and minimally invasive.
Rasania A, Pandey CL, Joshi N. Evaluation of FNAC in diagnosis of hepatitis lesion. J Cytol 2007;24:51-54
Fine needle aspiration cytology of liver: A study of 202 cases. Indian J Med Sci 2003;57(1):22-25
Diagnostic accuracy of percutaneous cytodiagnosis of hepatic masses by ultrasound guided fine needle aspiration cytology. Annals 2010;16(3):184-88
Scan-guided fine needle aspiration biopsy in malignant hepatic disease. Acta Cytol 1978;22:292-96
Fine needle aspiration cytodiagnosis of liver tumors. Acta Cytol 2004;48: 142-48
Differentiation of hepatocellular carcinoma from metastatic carcinoma of the liver–clinical and cytological features. J Cytol 2007;24(3):125-29
Sonography of diffuse liver disease. J Ultrasound Med 2002;21(9):1023-32
Fine needle aspiration cytology of liver. A study of 518 cases. J Cytol 2002;19:139-43
Fine needle aspiration of the liver. A study of 102 consecutive cases. Acta Cytol 1984;28: 719-25
The diagnostic role of fine needle aspiration cytology of liver in malignant focal mass lesions: A cytological correlation. JCPSP 2000;10:109-12
Fallacies of fine needle aspiration cytology of surgical lesions of liver. J Ind Med Assoc 1994;92:285-87
The diagnostic value of on-site cytopathological evaluation and cell block preparation in fine needle aspiration cytology of liver masses. Cytopathology 2006;17:267-74
Fine needle aspiration cytology in diagnosis of liver lesions. Hepatobilliary Pancreat Dis Int 2004;3(1):90-91
Value of ultrasonography- guided fine needle aspiration cytology in the investigative sequence of hepatic lesions with an emphasis on hepatocellular carcinoma. J Cytol 2011 Oct-Dec;28(4):178-84
Liver cell dysplasia: A premalignant condition. J Clin Path 1973;26:217-23
Histological features of cirrhosis with hepatitis C virus for prediction of Hepatocellular carcinoma development: A prospective study. Anti Cancer Res 2000;20(5C):3709-15.17. Das DK, Tripathy RP, Kumar N, et al. Role of guided fine needle aspiration cytology in diagnosis and classification of liver malignancies. Trop Gatroenterol 1997;18:101-06
Cytologic criteria to distinguish hepatocellular carcinoma from non-neoplastic liver. Am J Clin Pathol 1991;95:125-30
Cell features and patterns in fine needle aspirates of hepatocellular carcinoma. Cancer 1986;58:321-28
Ultrasound-guided fine needle aspiration in early detection of melanoma metastasis. Cancer 2000 Jun 25;90(3): 186-93.