Euroasian Journal of Hepato-Gastroenterology

Register      Login

VOLUME 3 , ISSUE 1 ( January-June, 2013 ) > List of Articles

ORIGINAL ARTICLE

Characteristics Features of Hepatocellular Carcinoma in Bangladesh and their Public Health Implications

Salimur Rahman, ABM Shakil Gani

Citation Information : Rahman S, Shakil Gani A. Characteristics Features of Hepatocellular Carcinoma in Bangladesh and their Public Health Implications. Euroasian J Hepatogastroenterol 2013; 3 (1):28-30.

DOI: 10.5005/jp-journals-10018-1057

License: CC BY-NC 4.0

Published Online: 00-00-0000


Abstract

Background/Objectives: In spite of being a common cancer, little is known about clinical presentation, etiological factors and prognosis of hepatocellular carcinoma (HCC) in Bangladesh. Accordingly, early detection and efficient management of HCC is not available at this country. Materials and methods: Demographical data, etiological factors and clinical presentations of 57 consecutive patients with HCC were analyzed prospectively at the only medical university of Bangladesh. Results: Ninety-one percent patients with HCC were male. The mean age of HCC patients was 45.8 years (standard deviation: 15.3 years; range: 18-75 years). All patients were symptomatic when they first appeared to the physicians, and many of them were unaware that they had been suffering from liver diseases. Hepatitis B surface antigen was detected in 62% and antibody to hepatitis C virus was found in 6% patients with HCC. Most of the patients with HCC had liver cirrhosis (77%). Single HCC nodule was detected in 61% patients. Sixty-four percent patients had intermediate stage of liver cancer. Conclusion: Containment of HCC-related morbidity and mortality and better prognosis of HCC in Bangladesh depends on early diagnosis of hepatitis viruses.


PDF Share
  1. El-Serag HB, Rudolph KL. Hepatocellular carcinoma: Epidemiology and molecular carcinogenesis. Gastroenterology 2007;132:2557-76
  2. The contributions of hepatitis B virus and hepatitis C virus infections to cirrhosis and primary liver cancer worldwide. J Hepatol 2006; 45:529-38
  3. Epidemiology, screening, diagnosis and treatment of hepatocellular carcinoma. Minerva Gastroenterol Dietol 2009;55:123-38
  4. The 2008 Okuda lecture: Management of hepatocellular carcinoma: From surveillance to molecular targeted therapy. J Gastroenterol Hepatol 2010;25:439-52
  5. Clinical features, etiology and survival of hepatocellular carcinoma among different countries. J Gastroenterol Hepatol 2002;17 Suppl:S40-49
  6. Hepatocellular carcinoma in the developing world. Semin Oncol 2001;28:179-87
  7. Epidemiology of hepatitis B virus in Bangladeshi general population. Hepatobilliary Pancreat Dis 2008;7:595-600
  8. Gastroenterol Jpn 1993;28: 28-31
  9. Etiology and clinical profile of hepatocellular carcinoma in Bangladesh. Bangladesh Med Res Counc Bull 1997;23:16-24
  10. Primary hepatocellular carcinoma and viral hepatitis B and C infection in Bangladeshi subjects. J Trop Med Hyg 1995;98:64-68
  11. Characteristics of hepatocellular carcinoma in India: A retrospective analysis of 191 cases. QJM 2008;101:479-85
  12. Clinical management of hepatocellular carcinoma. Conclusions of the Barcelona-2000 EASL conference. European Association for the Study of the Liver. J Hepatol 2001;35:421-30.
PDF Share

© Jaypee Brothers Medical Publishers (P) LTD.