Hepatoprotective Effect of Tribulus terrestris L against
Acetaminophen-Induced Liver Damage in Wistar Rats
Javed Akhtar Ansari, Abdul Mateen Sayyed, R Manavalan, Balamurgan
Citation Information :
Akhtar Ansari J, Mateen Sayyed A, Manavalan R, B. Hepatoprotective Effect of Tribulus terrestris L against Acetaminophen-Induced Liver Damage in Wistar Rats. Euroasian J Hepatogastroenterol 2013; 3 (1):15-18.
Background: Nowaday’s liver diseases due to exposure of
different drug molecules are very common. The aim of the
present study was to investigate the effect of methanolic extract
of Tribulus terrestris L (TT) against acetaminophen (AA)-induced
liver damage in Wistar rats.
Materials and methods: Animals were divided into five groups
of six rats each.
Results and discussion: Oral administration of TT (500 mg/kg)
along with AA (2.5 gm/kg) showed a significant decrease in
serum enzyme aspartate aminotransferase (AST), alanine
aminotransferase (ALT), total bilirubin, direct bilirubin and
alkaline phosphatase (ALP) levels with a decrease in total protein
levels (p < 0.01). The results were comparable with silymarin
(SL), a standard hepatoprotective drug. The present study
reveals that the administration of TT can be beneficial for the
suppression of liver damage. Based on present findings, it can
be concluded that methanolic extract of TT protects the liver
from AA-induced liver damage. The present study for the first
time reports the hepatoprotective potential of TT in AA-induced
liver damage in Wistar rats.
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