Euroasian Journal of Hepato-Gastroenterology

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VOLUME 2 , ISSUE 2 ( July-December, 2012 ) > List of Articles

ORIGINAL ARTICLE

High HBcAg Expression in Hepatocytes of Chronic Hepatitis B Patients in Bangladesh

Munira Jahan, Shahina Tabassum, Afzalun Nessa, Chowdhury Mohammad Shamim Kabir

Citation Information : Jahan M, Tabassum S, Nessa A, Mohammad Shamim Kabir C. High HBcAg Expression in Hepatocytes of Chronic Hepatitis B Patients in Bangladesh. Euroasian J Hepatogastroenterol 2012; 2 (2):63-69.

DOI: 10.5005/jp-journals-10018-1036

License: CC BY-NC 4.0

Published Online: 01-07-2012


Abstract

The present study evaluates the intracellular expression of the hepatitis B Virus (HBV) core antigen in chronic hepatitis B (CHB) patients from Bangladesh in relation with serological, virological and histological variables. A cross-sectional study was carried out among 70 patients incidentally diagnosed as HBV chronic carriers who have undergone liver biopsy. Indirect immunofluorescence technique was used to study the intracellular expression of hepatitis B core antigen (HBcAg). The grade and cellular distribution were semiquantitatively scored according to the percentage of stained cells and their nuclear, cytoplasmic or mixed expression pattern respectively. A higher HBcAg grade was related to higher viral load, alanine aminotransferase levels and histological damage. Higher HBV DNA counts and HBcAg grade were found in hepatitis B e antigen (HBeAg)-positive patients.


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