Euroasian journal of hepato-gastroenterology

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VOLUME 2 , ISSUE 1 ( January-June, 2012 ) > List of Articles


CagA Helicobacter pylori Seropositivity in Asymptomatic, Apparently Healthy, Young Adult Egyptian Food Handlers

Yahia Zakaria Gad, Amany Mohammad Hassan

Citation Information : Zakaria Gad Y, Mohammad Hassan A. CagA Helicobacter pylori Seropositivity in Asymptomatic, Apparently Healthy, Young Adult Egyptian Food Handlers. Euroasian J Hepatogastroenterol 2012; 2 (1):20-23.

DOI: 10.5005/jp-journals-10018-1025

License: CC BY-NC 4.0

Published Online: 01-08-2018

Copyright Statement:  Copyright © 2012; The Author(s).


Background/Aim: Infection with CagA Helicobacter pylori (H. pylori) positive strain is a risk factor for the development of atrophic gastritis and gastric adenocarcinoma. This study investigated the seroprevalence of H. pylori and its virulent strains CagA in Egyptian food handlers. Subjects and methods: A total of 365 eligible male subjects participated in the initial study. Venous blood samples were collected from all participants for assessment of H. pylori specific IgG and serum CagA antibodies. Results: Out of 365 subjects, 310 were reactive to H. pylori. Out of them, CagA was detected in 143 H. pylori-infected subjects. CagA antibodies were more common in cigarette smokers (< 0.001), living in high crowding index (< 0.001), with low family income (< 0.01) and sharing their bedrooms during childhood (< 0.001). Conclusion: Our data revealed a high prevalence of CagA virulent strains among asymptomatic apparent food handlers of Egypt. Emergency surveillance mechanisms should be developed for containment of H. pylori infection in Egypt.

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