CagA Helicobacter pylori Seropositivity in Asymptomatic,
Apparently Healthy, Young Adult Egyptian Food Handlers
Yahia Zakaria Gad, Amany Mohammad Hassan
Citation Information :
Zakaria Gad Y, Mohammad Hassan A. CagA Helicobacter pylori Seropositivity in Asymptomatic, Apparently Healthy, Young Adult Egyptian Food Handlers. Euroasian J Hepatogastroenterol 2012; 2 (1):20-23.
Background/Aim: Infection with CagA Helicobacter pylori
(H. pylori) positive strain is a risk factor for the development of
atrophic gastritis and gastric adenocarcinoma. This study
investigated the seroprevalence of H. pylori and its virulent
strains CagA in Egyptian food handlers.
Subjects and methods: A total of 365 eligible male subjects
participated in the initial study. Venous blood samples were
collected from all participants for assessment of H. pylori specific
IgG and serum CagA antibodies.
Results: Out of 365 subjects, 310 were reactive to H. pylori.
Out of them, CagA was detected in 143 H. pylori-infected
subjects. CagA antibodies were more common in cigarette
smokers (< 0.001), living in high crowding index (< 0.001), with
low family income (< 0.01) and sharing their bedrooms during
childhood (< 0.001).
Conclusion: Our data revealed a high prevalence of CagA
virulent strains among asymptomatic apparent food handlers
of Egypt. Emergency surveillance mechanisms should be
developed for containment of H. pylori infection in Egypt.
Marshal BJ, Warren JR. Unidentified curved bacilli in the stomach of patients with gastritis and peptic ulcerations. Lancet 1984;1:1311-15
Helicobacter pylori persistence; biology and disease. J Clin Invest 2004;113:321-33
Helicobacter pylori virulence and genetic geography. Science 1999;284:1328-33
Analysis of Helicobacter pylori VacA and CagA genotypes and serum antibody profile in benign and malignant gastroduodenal diseases. Gut 1998;43: 182-86
Helicobacter pylori and atrophic gastritis: Importance of cagA status. J Natl Cancer Inst 1995;87:1777-80
Infection with Helicobacter pylori strains possessing CagA is associated with increased risk of developing adenocarcinoma of the stomach. Cancer Res 1995;55:2111-15
British regional heart study: Cardiovascular risk factors in middle-aged men in 24 towns. BMJ 1981;183:179-83
Epidemiology of Helicobacter pylori infection. Helicobacter 2004:Suppl(9)1: 1-6
Epidemiologic observations and open questions about disease and infection caused by Helicobacter pylori In: Achtman M, Suerbaum S, (Eds). Helicobacter pylori: Molecular and cellular biology. Wymondham, United Kingdom: Horizon Scientific Press 2001:29-51
Epidemiology of, and risk factors of Helicobacter pylori infection among 3194 asymptomatic subjects in 17 populations. Gut 1993;34;1672-76
A secreted / shed product of Helicobacter pylori activates transcription factor nuclear factor kappa B. J Immunol 1997;159:6140-47
The incidence of Helicobacter pylori acquisition in children of a Canadian First Nations community and the potential for parent to child transmission. Helicobacter 2004;9:59-68
Epidemiology of Helicobacter pylori infection. Helicobacter 2007;12(Suppl 1):1-3
Age at establishment of Helicobacter pylori infection and gastric carcinoma, gastric ulcer and duodenal ulcer risk. Cancer Res 1995;55:562-65.