Intraductal Papillary Neoplasm of the Bile Duct: Radiological Diagnosis of a Rare Entity: Case Series

Kaustav Jain

doi:10.5005/jp-journals-10018-1385

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Intraductal Papillary Neoplasm of the Bile Duct: Radiological Diagnosis of a Rare Entity: Case Series

Kaustav Jain

Keywords : Biliary papillomatosis, Cholangiocarcinoma, Intraductal papillary mucinous neoplasm, Intraductal papillary neoplasm of bile duct

Citation Information : Jain K. Intraductal Papillary Neoplasm of the Bile Duct: Radiological Diagnosis of a Rare Entity: Case Series. Euroasian J Hepatogastroenterol 2023; 13 (1):28-31.

DOI: 10.5005/jp-journals-10018-1385

License: CC BY-NC 4.0

Published Online: 03-08-2023

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Abstract

Background: Intraductal papillary neoplasm of the bile duct (IPNB) is a rare bile duct neoplasm characterized by an intraluminal papillary growth pattern in bile ducts and is considered a biliary counterpart of intraductal papillary mucinous neoplasm of the pancreas. Case description: We report here two cases. (1) A case of a 34-year-old woman who presented with complaints of pain in the abdomen, jaundice, and pruritus. Further radiological investigations revealed the possibility of an IPNB, which was confirmed on histopathology. (2) A case of a 61-year-old man who was a known case of Barrett's esophagus and presented with complaints of right upper abdomen and jaundice. Radiological investigations and histopathology further confirmed the diagnosis of an IPNB involving the extrahepatic bile ducts. The purpose of this article is to highlight the role of computed tomography (CT) and magnetic resonance imaging in reaching this challenging diagnosis. Conclusion: Although the diagnosis is not straightforward, imaging plays a great role in raising the possibility of an IPNB. The correct preoperative diagnosis is necessary for accurate surgical planning and resection.

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Bosman FT, Carneiro F, Hruban RH, et al. (Eds). WHO classification of tumours of the digestive system, 4th edition. Lyon, France: IARC; 2010.
Tan Y, Milikowski C, Toribio Y, et al. Intraductal papillary neoplasm of the bile ducts: A case report and literature review. World J Gastroenterol 2015;21(43):12498–12504. DOI: 10.3748/wjg.v21.i43.12498.
Chatterjee A, Lopes Vendrami C, Nikolaidis P, et al. Uncommon intraluminal tumors of the gallbladder and biliary tract: Spectrum of imaging appearances. Radiographics 2019;39(2):388–412. DOI: 10.1148/rg.2019180164.
Ohtsuka M, Shimizu H, Kato A, et al. Intraductal papillary neoplasms of the bile duct. Int J Hepatol 2014;ID: 459091. DOI: 10.1155/2014/459091.
Wan XS, Xu YY, Qian JY, et al. Intraductal papillary neoplasm of the bile duct. World J Gastroenterol 2013;19:8595–8604. DOI: 10.1155/2014/459091.
Schlitter AM, Born D, Bettstetter M, et al. Intraductal papillary neoplasms of the bile duct: Stepwise progression to carcinoma involves common molecular pathways. Mod Pathol 2014;27:73–86. DOI: 10.1038/modpathol.2013.112.
Lim JH, Yoon KH, Kim SH, et al. Intraductal papillary mucinous tumor of the bile ducts. RadioGraphics 2004;24(1):53–66; discussion 66–67. DOI: 10.1148/rg.241035002.
Ying S, Ying M, Liang W, et al. Morphological classification of intraductal papillary neoplasm of the bile duct. Eur Radiol 2018;28(4):1568–1578. DOI: 10.1007/s00330-017-5123-2.
Ogawa H, Itoh S, Nagasaka T, et al. CT findings of intraductal papillary neoplasm of the bile duct: Assessment with multiphase contrast-enhanced examination using multi-detector CT. Clin Radiol 2012;67(3):224–231. DOI: 10.1016/j.crad.2011.08.015.

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