Euroasian journal of hepato-gastroenterology

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VOLUME 13 , ISSUE 1 ( January-June, 2023 ) > List of Articles


Acute Hepatitis in an Immunosuppressed Patient: A Dilemma

Tarana Gupta

Keywords : Acute hepatitis, Carcinoma buccal mucosa, Cisplatin, Occult hepatitis B, Occult hepatitis C

Citation Information : Gupta T. Acute Hepatitis in an Immunosuppressed Patient: A Dilemma. Euroasian J Hepatogastroenterol 2023; 13 (1):26-27.

DOI: 10.5005/jp-journals-10018-1368

License: CC BY-NC 4.0

Published Online: 03-08-2023

Copyright Statement:  Copyright © 2023; The Author(s).


Acute hepatitis in patients on chemotherapy has always been challenging. Demystifying the truth becomes essential to continue chemotherapy. We present a case of carcinoma buccal mucosa who developed acute hepatitis following a single dose of cisplatin and radiotherapy. In the background of a history of chronic alcoholism, and alcohol abstinence of more than 3 months, acute alcoholic hepatitis was unlikely. Though he had occult hepatitis B with HBsAg negative and positive IgG anti-HBc antibody status, however, with undetectable HBV DNA PCR quantitative, hepatitis B was unlikely to be the cause of acute hepatitis. With all viral markers including atypical viruses and autoimmune work-up being negative, it was a real-time challenge to find the exact cause.

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