Euroasian Journal of Hepato-Gastroenterology

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VOLUME 11 , ISSUE 1 ( January-June, 2021 ) > List of Articles

Original Article

Clinical Manifestations of Hospitalized COVID-19 Patients in Bangladesh: A 14-day Observational Study

Modhusudon Shaha, Md A Islam, Faizul Huq, Bithi Roy, Md A Kabir, Md Salimullah, Sheikh MF Akbar

Keywords : Blood hemoglobin, Clinical manifestations, Comorbidity, COVID-19, Liver functionality, Pneumonia

Citation Information : Shaha M, Islam MA, Huq F, Roy B, Kabir MA, Salimullah M, Akbar SM. Clinical Manifestations of Hospitalized COVID-19 Patients in Bangladesh: A 14-day Observational Study. Euroasian J Hepatogastroenterol 2021; 11 (1):14-20.

DOI: 10.5005/jp-journals-10018-1340

License: CC BY-NC 4.0

Published Online: 28-06-2021

Copyright Statement:  Copyright © 2021; The Author(s).


Objectives: Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is currently a significant public health concern and causing a pandemic in the world. Despite immense attention to the coronavirus disease 2019 (COVID-19), very little attention has been given to the kinetics of disease progression in infected patients. Therefore, in this study, we present a 14-day clinical observation of hospital-admitted COVID-19 patients. Methods: After recording the demography of 42 COVID-19 patients on day 1, we observed the clinical progression for 14 days by investigating the hematological and biochemical responses of patients’ blood and serum, respectively. Results: Approximately, 62% of the hospital-admitted COVID-19 patients presented cough, followed by fever (~52%). The top comorbidities of these patients were hypertension (30%) and diabetes mellitus (19%). The average blood hemoglobin (Hb) level was slightly low among the patients in the early days of infection and went up to the normal level on the later days. A substantial increase in the level of ALT or SGPT [up to 106 IU/L; standard error of the mean (SEM): 12.64] and AST or SGOT (up to 64.35 IU/L; SEM: 5.013) in COVID-19 patients was observed, which may suggest that infection with coronavirus is associated with the functionality of other organs of COVID-19 patients. Conclusion: This 14-day observational study may help clinicians to decide the choice of treatment for COVID-19 patients.

  1. Cherry JD. The chronology of the 2002–2003 SARS mini pandemic. Paediatr Respir Rev 2004;5(4):262–269. DOI: 10.1016/j.prrv.2004.07.009.
  2. Milne-Price S, Miazgowicz KL, Munster VJ. The emergence of the Middle East respiratory syndrome coronavirus. Pathog Dis 2014;71(2):121–136. DOI: 10.1111/2049-632x.12166.
  3. Rodriguez-Morales AJ, Bonilla-Aldana DK, Balbin-Ramon GJ, et al. History is repeating itself: Probable zoonotic spillover as the cause of the 2019 novel coronavirus epidemic. Infez Med 2020;28(1):3–5.
  4. Zhu N, Zhang D, Wang W, et al. A novel coronavirus from patients with pneumonia in China, 2019. N Engl J Med 2020;82(8):727–733. DOI: 10.1056/NEJMoa2001017.
  5. WHO. Available from: [Accessed on March 28, 2021]; 2020.
  6. Kirby T. New variant of SARS-CoV-2 in UK causes surge of COVID-19. Lancet Respir Med 2021;9(2):e20–e21. DOI: 10.1016/s2213-2600(21)00005-9.
  7. Le Page M. What are the new coronavirus variants? New scientist (1971) 2021;249(3318):9–9. DOI: 10.1016/S0262-4079(21)00081-6.
  8. Hossain ME, Rahman MM, Alam MS, et al. Genome sequence of a SARS-CoV-2 strain from Bangladesh that is nearly identical to United Kingdom SARS-CoV-2 variant B.1.1.7. Microbiol Resour Announc 2021;10(8):e00100–e00121. DOI: 10.1128/MRA.00100-21.
  9. Hasan MM, Das R, Uzzaman MR, et al. Global and local mutations in Bangladeshi SARS-CoV-2 genomes. Virus Res 2021;297:198390–198390.DOI: 10.1016/j.virusres.2021.198390.
  10. Moniruzzaman M, Hossain MU, Islam MN, et al. Coding-complete genome sequence of SARS-CoV-2 isolate from Bangladesh by sanger sequencing. Microbiol Resour Announc 2020;9(28). DOI: 10.1128/mra.00626-20.
  11. Hossain MU, Bhattacharjee A, Emon MTH, et al. Novel mutations in NSP-1 and PLPro of SARS-CoV-2 NIB-1 genome mount for effective therapeutics. J Genet Eng Biotechnol 2021;19(1):52. DOI: 10.1186/s43141-021-00152-z.
  12. Teasdale G, Jennett B. Assessment of coma and impaired consciousness. A practical scale. Lancet 1974;2(7872):81–84. DOI: 10.1016/s0140-6736(74)91639-0.
  13. Zhou F, Yu T, Du R, et al. Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. Lancet 2020;395(10229):1054–1062. DOI: 10.1016/s0140-6736(20)30566-3.
  14. Hasan MJ, Anam AM, Huq SM, et al. Impact of comorbidities on clinical outcome of patients with COVID-19: evidence from a single-center in Bangladesh. Health Scope 2021;10(1):e109268. DOI: 10.5812/jhealthscope.109268.
  15. Hossain I, Mullick AR, Khan MH, et al. Comorbidity and it's impact on COVID-19 affected patients in COVID-19 dedicated hospital of Bangladesh. Bangladesh Med J 2020;49(1):19–25. DOI: 10.3329/bmj.v49i1.52585.
  16. Mowla SGM, Azad KAK, Kabir A, et al. Clinical profile of 100 confirmed COVID-19 patients admitted in Dhaka Medical College Hospital, Dhaka, Bangladesh. J Bangladesh Coll Phys Surg 2020;38:29–36. DOI: 10.3329/jbcps.v38i0.47445.
  17. Bhuyan MA, Mahtab MA, Ashab E, et al. Treatment of COVID-19 patients at a medical college hospital in Bangladesh. Eur J Hepato-Gastroenterol 2020;10(1):27. DOI: 10.5005/jp-journals-10018-1317.
  18. Guan WJ, Liang WH, Zhao Y, et al. Comorbidity and its impact on 1590 patients with COVID-19 in China: a nationwide analysis. Eur Respir J 2020;55(5):2000547. DOI: 10.1183/13993003.00547-2020.
  19. Ng WH, Tipih T, Makoah NA, et al. Comorbidities in SARS-CoV-2 patients: a systematic review and meta-analysis. mBio 2021;12(1):e03647–e03720. DOI: 10.1128/mBio.03647-20.
  20. Sanyaolu A, Okorie C, Marinkovic A, et al. Comorbidity and its impact on patients with COVID-19. SN Compr Clin Med 2020:1–8. DOI: 10.1007/s42399-020-00363-4.
  21. Lippi G, Mattiuzzi C. Hemoglobin value may be decreased in patients with severe coronavirus disease 2019. Hematol Transfus Cell Ther 2020;42(2):116–117. DOI: 10.1016/j.htct.2020.03.001.
  22. Gowda S, Desai PB, Hull VV, et al. A review on laboratory liver function tests. Pan Afr Med J 2009;3:17.
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