Euroasian Journal of Hepato-Gastroenterology

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VOLUME 10 , ISSUE 2 ( July-December, 2020 ) > List of Articles

Original Article

Effect of Nonsurgical Treatment on Salivary HGF Levels in Population with Periodontal Disease: A Quasi-experimental Study

Dalip Alreja, Jyoti R Rao, Sakshi Kataria, Dhaval A Faterpenkar

Keywords : Biomarker, Boster\'s human HGF ELISA Kit®, Chronic periodontitis, Enzyme-linked immunosorbent assay, Gingivitis, Hepatocyte growth factor, Periodontal disease, Salivary hepatocyte growth factor

Citation Information : Alreja D, Rao JR, Kataria S, Faterpenkar DA. Effect of Nonsurgical Treatment on Salivary HGF Levels in Population with Periodontal Disease: A Quasi-experimental Study. Euroasian J Hepatogastroenterol 2020; 10 (2):51-55.

DOI: 10.5005/jp-journals-10018-1320

License: CC BY-NC 4.0

Published Online: 06-01-2021

Copyright Statement:  Copyright © 2020; Jaypee Brothers Medical Publishers (P) Ltd.


Aim: To assess the effect of nonsurgical treatment on salivary hepatocyte growth factor (sHGF) levels in a population with periodontal disease: a quasi-experimental study. Methods: Eighty-one patients (aged 30–70 years) were divided into three groups based on the gingival index, probing depth, clinical attachment loss, and radiographic evidence of bone loss: healthy (group I), gingivitis (group II), and chronic periodontitis (group III). Saliva samples were collected from these groups at baseline. At 8 weeks, saliva samples were collected again from group II and group III after the patients went through nonsurgical periodontal treatment. The levels of HGF were estimated using enzyme-linked immunosorbent assay (ELISA). The clinical parameters and HGF levels among all groups were analyzed using a one-way analysis of variance (ANOVA) using SPSS 17 version. Results: At baseline, the highest mean HGF concentration in saliva was observed for group III (3455.83 ± 1463.44 pg/mL), and the least in group I (469.43 ± 317.13 pg/mL). Following nonsurgical periodontal treatment, the mean HGF concentration decreased significantly in group III and group II (p < 0.05). A significant positive correlation between clinical parameters and HGF levels was also seen (p < 0.05). Conclusion: HGF concentration showed a positive correlation with the progression of periodontal disease. Clinical significance: Following nonsurgical periodontal therapy, the levels of HGF decreased significantly, suggesting that HGF could be useful for monitoring the response to periodontal therapy.

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