Evaluation of Fibrosis Progression by
Noninvasive Biochemical Markers in
Egyptian Patients with Chronic Hepatitis B
Tarek A Besheer, Mahmoud M El-Bendary, Khaled R Zalata, Hossam E Zaghalol
Citation Information :
A Besheer T, M El-Bendary M, R Zalata K, E Zaghalol H. Evaluation of Fibrosis Progression by Noninvasive Biochemical Markers in Egyptian Patients with Chronic Hepatitis B. Euroasian J Hepatogastroenterol 2011; 1 (2):71-76.
Background: To evaluate the usefulness of biochemical markers for prediction of fibrosis in chronic hepatitis B.
Materials and methods: This study was carried out on 133 patients with chronic hepatitis B. The diagnostic accuracy of four noninvasive liver
fibrosis markers; matrix metalloproteinase-2 (MMP-2), hyaluronic acid (HA), aspartate aminotransferase (AST) to platelet ratio index (APRI)
and FIB-4 was evaluated.
Results: The levels of HA and MMP-2 were increased along with the severity of fibrosis. The cutoff value for HA was 265 ng/ml for predicting
liver cirrhosis, whereas cutoff value for MMP-2 was 860 ng/ml. The cutoff value for APRI for detecting severe fibrosis (F3 and F4) was ≥ 0.9.
Finally, cutoff value for FIB-4 was ≥ 0.9 for assessment of severe fibrosis in chronic hepatitis B.
Conclusion: HA, MMP-2, APRI and FIB-4 could be clinically useful as noninvasive markers for detection of severe fibrosis in chronic hepatitis B.
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