Euroasian journal of hepato-gastroenterology

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VOLUME 1 , ISSUE 2 ( July-December, 2011 ) > List of Articles


Evaluation of Fibrosis Progression by Noninvasive Biochemical Markers in Egyptian Patients with Chronic Hepatitis B

Tarek A Besheer, Mahmoud M El-Bendary, Khaled R Zalata, Hossam E Zaghalol

Citation Information : A Besheer T, M El-Bendary M, R Zalata K, E Zaghalol H. Evaluation of Fibrosis Progression by Noninvasive Biochemical Markers in Egyptian Patients with Chronic Hepatitis B. Euroasian J Hepatogastroenterol 2011; 1 (2):71-76.

DOI: 10.5005/jp-journals-10018-1016

License: CC BY-NC 4.0

Published Online: 01-01-2011

Copyright Statement:  Copyright © 2011; The Author(s).


Background: To evaluate the usefulness of biochemical markers for prediction of fibrosis in chronic hepatitis B. Materials and methods: This study was carried out on 133 patients with chronic hepatitis B. The diagnostic accuracy of four noninvasive liver fibrosis markers; matrix metalloproteinase-2 (MMP-2), hyaluronic acid (HA), aspartate aminotransferase (AST) to platelet ratio index (APRI) and FIB-4 was evaluated. Results: The levels of HA and MMP-2 were increased along with the severity of fibrosis. The cutoff value for HA was 265 ng/ml for predicting liver cirrhosis, whereas cutoff value for MMP-2 was 860 ng/ml. The cutoff value for APRI for detecting severe fibrosis (F3 and F4) was ≥ 0.9. Finally, cutoff value for FIB-4 was ≥ 0.9 for assessment of severe fibrosis in chronic hepatitis B. Conclusion: HA, MMP-2, APRI and FIB-4 could be clinically useful as noninvasive markers for detection of severe fibrosis in chronic hepatitis B.

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